Phototherapy and anti-GITR antibody-based therapy synergistically reinvigorate immunogenic cell death and reject established cancers

Sun, Qi; Yang, Zhenzhen; Meng, Lin; Yan, Peng; Wang, Rudong; Du, Yitian; Zhou, Yu; Li, Jiajia; Qi, Xian-Rong

doi:10.1016/j.biomaterials.2020.120648

Cited by 37 publications

(29 citation statements)

References 39 publications

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“…Compared with DA, the peak appearing at 1625 cm −1 of PDA NTs and PDA/Cur NFs can be attributed to the aromatic ring skeleton stretching vibration, while the broad peak at 2900–3700 cm −1 is due to the abundance of OH groups. The above results indicated that PDA/Cur NFs were successfully synthesized, which is in agreement with previous studies [ 50 – 53 ]. In addition to the peak at 1512 cm −1 , other bands in the FTIR spectrum of Cur were almost absent in the spectrum of PDA/Cur NFs, possibly because the Cur loading was only 10%.…”

Section: Resultssupporting

confidence: 92%

Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds

et al. 2021

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Background Diabetic wound healing remains a challenge because of its susceptibility to drug-resistant bacterial infection and its persistent proinflammatory state. Switching from proinflammatory M1 macrophages (Mφs) to proregenerative M2 dominant Mφs in a timely manner accelerates wound healing by coordinating inflammatory, proliferative, and angiogenic processes. Methods We propose a sequential photothermal antibacterial and subsequent M2 Mφ polarization strategy based on nanofibers (NFs) consisting of polydopamine (PDA) coating on curcumin (Cur) nanocrystals to treat Methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wounds. Results The PDA/Cur NFs showed excellent photothermal conversion and antibacterial effects due to the PDA shell under laser irradiation, consequently resulting in the release of the inner Cur with the ability to promote cell proliferation and reinforce the M2 Mφ phenotype in vitro. In vivo studies on MRSA-infected diabetic wounds showed that PDA/Cur NFs not only inhibited MRSA infection but also accelerated the wound regeneration process. Furthermore, the NFs displayed the ability to promote the M2 Mφ phenotype with enhanced collagen deposition, angiogenesis, and cell proliferation. Conclusion Overall, the NFs displayed great potential as promising therapeutics for healing infected diabetic wounds through a sequential photothermal antibacterial and M2 Mφ polarization strategy. Graphical abstract

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Section: Resultssupporting

confidence: 92%

Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds

et al. 2021

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“…Sun et al. 151 developed an immunomodulating nanosystem based on the combination of phototherapy and immunotherapy, which was denoted as PDA-ICG@CAT-DTA-1. Catalase (CAT) and anti-GITR antibody (DTA-1) were co-loaded to nanoparticles comprised of photothermal agent polydopamine (PDA) and photosensitizer indocyanine green (ICG).…”

Section: Strategies For Remodeling Immunosuppressive Tmementioning

confidence: 99%

Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

Xiong

Sun

et al. 2022

Acta Pharmaceutica Sinica B

103

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“…In addition, increasing the ROS of TME reduced the production of T-regs. Catalase loaded onto polydopamine -ICG nanoparticles and pH-sensitive polymethacrylate-coated CaO 2 nanoparticles enhanced ROS generation in tumors, resulting in the reduction of intratumoral FOXP3+ regulatory T cells ( Table 1 ) ( Nicholas et al, 2021 ; Sun et al, 2021 ).…”

Section: Nanomaterials For Regulating T Cells To Trigger Abscopal Eff...mentioning

confidence: 99%

Engineered nanomaterials trigger abscopal effect in immunotherapy of metastatic cancers

Xia

Yang

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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Despite advances in cancer treatment, metastatic cancer is still the main cause of death in cancer patients. At present, the treatment of metastatic cancer is limited to palliative care. The abscopal effect is a rare phenomenon in which shrinkage of metastatic tumors occurs simultaneously with the shrinkage of a tumor receiving localized treatment, such as local radiotherapy or immunotherapy. Immunotherapy shows promise for cancer treatment, but it also leads to consequences such as low responsiveness and immune-related adverse events. As a promising target-based approach, intravenous or intratumoral injection of nanomaterials provides new opportunities for improving cancer immunotherapy. Chemically modified nanomaterials may be able to trigger the abscopal effect by regulating immune cells. This review discusses the use of nanomaterials in killing metastatic tumor cells through the regulation of immune cells and the prospects of such nanomaterials for clinical use.

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Phototherapy and anti-GITR antibody-based therapy synergistically reinvigorate immunogenic cell death and reject established cancers

Cited by 37 publications

References 39 publications

Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds

Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds

Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

Engineered nanomaterials trigger abscopal effect in immunotherapy of metastatic cancers

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