Photosynthesized escin stabilized gold nanoparticles exhibit antidiabetic activity in L6 rat skeletal muscle cells

Shamprasad, Bhanuvalli R.; Keerthana, S.; Megarajan, Sengan; Lotha, Robert; Sivasubramanian, Aravind; Veerappan, Anbazhagan

doi:10.1016/j.matlet.2019.01.086

Cited by 14 publications

(14 citation statements)

References 9 publications

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“…In general, the results showed that LSTE, F1, F2 and their Au NPs had the potential to be used as antidiabetic agents. Pure isolated phytochemicals have demonstrated activities against alpha-glucosidase in previous studies [47,48]. Recently, Etsassala et al [89] reported a strong antidiabetic activity of ten abietane diterpenes.…”

Section: In-vitro Antidiabetic Studiesmentioning

confidence: 95%

“…Furthermore, since no external stabilizers were employed, it could also be concluded that the same constituents were responsible for the stabilization of the nanoparticles (see Scheme 1). Many investigations concluded that polyphenols, which are abundant in plants, are associated with the reduction of metal salts when combined with plant extracts [47,48]. This may also explain why F1 and F2 (which contain similar functionality) were not only able to reduce gold to its zero-valence state but also formed Au NPs with very similar characteristics to that of the LSTE.…”

Section: Uv-visible Spectroscopic Analysismentioning

confidence: 99%

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Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

et al. 2020

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In this study, procyanidins fractions of dimers and trimers (F1-F2) from the Leucosidea sericea total extract (LSTE) were investigated for their chemical constituents. The total extract and the procyanidins were employed in the synthesis of gold nanoparticles (Au NPs) and fully characterized. Au NPs of 6, 24 and 21 nm were obtained using LSTE, F1 and F2 respectively. Zeta potential and in vitro stability studies confirmed the stability of the particles. The enzymatic activity of LSTE, F1, F2 and their corresponding Au NPs showed strong inhibitory alpha-amylase activity where F1 Au NPs demonstrated the highest with IC 50 of 1.88 µg/mL. On the other hand, F2 Au NPs displayed the strongest alpha-glucosidase activity at 4.5 µg/mL. F2 and F2 Au NPs also demonstrated the highest antioxidant activity, 1834.0 ± 4.7 µM AAE/g and 1521.9 ± 3.0 µM TE/g respectively. The study revealed not only the ability of procyanidins dimers (F1 and F2) in forming biostable and bioactive Au NPs but also, a significant enhancement of the natural products activities, which could improve the smart delivery in future biomedical applications.Biomolecules 2020, 10, 452 2 of 24 applying nanoparticles through the green route is their biocompatibility [5]. Many green synthesized nanoparticles have demonstrated interesting biological activities [5,10] including antimicrobial and antidiabetic properties.Diabetes mellitus has undoubtedly become a serious health challenge. More worrisome is type II diabetes mellitus (T2DM), which accounts for 90% of diabetes mellitus. It occurs as a result of the inefficient processing of insulin [11]. As of 2017, the population of adults between the ages of 20 and 79 that suffered from diabetes was 425 million [12]. This is equivalent to 9.9% of the world's population [12]. By estimation, this disease would have drastically increased by 48% in 28 years if not properly managed [13]. Although drugs like miglitol, vigliobose as well as acarbose are available in the market, they are costly and their continuous use is associated with side effects like diarrhea, dropsy, heart failure, damage to the liver, weight gain, abdominal pain, hyperglycemia, and flatulence, necessitating the need for more potent and newer remedies [14][15][16].It is well established that bioactive compounds in various plants possess significant effects in delaying and management of T2DM [17]. Extracts from different plants have been reported as alpha-glucosidase and alpha-amylase inhibitors [18][19][20][21][22][23][24][25][26][27]. Additionally, biologically synthesized Au NPs using plant extracts showed interesting antidiabetic activity. The extracts of Chamalcostus cuspidatus [28], Gymnema sylvestre [29], Cassia fistula stem bark [30], Hericium erinaceus [31], Turbinaria conoides [32], Sambucus nigra [33] and Sargassum swartzi [34] displayed antidiabetic activities in various investigations. Silver/gold NPs of Ocimum basilicum [35] and cinnamon extract [36] also lowers glucose levels. The use of single molecules as reducing/stabilizing agents for ...

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Section: In-vitro Antidiabetic Studiesmentioning

confidence: 95%

Section: Uv-visible Spectroscopic Analysismentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

et al. 2020

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“…Escin, a bioactive mixture of saponins in horse chestnut seeds, is known for its hypoglycaemic and anti-inflammatory effects [340,341]. To improve therapeutic efficacy and biocompatibility, Shamprasad and co-workers formulated escin-fabricated gold nanoparticles via natural sunlight-mediated synthesis [342]. Escin-gold nanoparticles have been found to possess better pharmacological efficacy in improving glucose uptake by skeletal muscle and promoting radical scavenging effect in vitro than native escin [342].…”

Section: Other Plant-derived Antidiabetic Nanoformulationsmentioning

confidence: 99%

“…To improve therapeutic efficacy and biocompatibility, Shamprasad and co-workers formulated escin-fabricated gold nanoparticles via natural sunlight-mediated synthesis [342]. Escin-gold nanoparticles have been found to possess better pharmacological efficacy in improving glucose uptake by skeletal muscle and promoting radical scavenging effect in vitro than native escin [342]. Guavanoic acid, an antidiabetic lead from Psidium guajava leaves, has been formulated as guavanoic-acid-gold nanoparticles and separated by the classical chromatographic methods [343].…”

Section: Other Plant-derived Antidiabetic Nanoformulationsmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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“…Nowadays, gold nanoparticles (AuNPs) have found interesting biomedical applications such as in drug delivery, cancer treatment, photothermal and photodynamic therapy [1]. This is due to their interesting physical characteristics such as surface plasmon resonance which can be used for a variety of applications by tuning the size, shape, and morphology [2][3]. To produce AuNPs, physical and chemical methods were popular until sophisticated instrumentation, cost of analysis [4] and the hazardous chemicals employed became a concern, especially when the nanoparticles (NPs) are targeted for biomedical applications [5].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties and in vitro stability studies of green synthesized gold nanoparticles using pelargonium sidoides

Badeggi¹,

Lawal²,

Akinfenwa³

et al. 2020

Nig. J. Tech.

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In the present study, Pelargonium sidoides (PS) extract was used in the green synthesis of AuNPs that was characterized by UV-Vis, TEM, SAED, EDS, XRD, FTIR, and DLS. UV-Vis showed a surface plasmon resonance (SPR) at λmax of 532 nm while TEM shows that the particles are predominantly spherical and monodispersed. DLS measurement indicated the particle size and the zeta potential to be 27.20 nm and -24.0 mV respectively. The in vitro stability of the hybrid particles in different solutions and buffers (pH 7 and 9) confirmed that the particles are stable over a given period. The method employed is simple, environmentally friendly, and inexpensive. Our studies suggest that the Pelargonium sidoides-gold nanoparticles (PS-AuNPs) may be safely used in biomedical applications such as drug delivery. Keywords: Pelargonium sidoides; biosynthesis; biomedicals; capping agent; zeta potential

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Photosynthesized escin stabilized gold nanoparticles exhibit antidiabetic activity in L6 rat skeletal muscle cells

Cited by 14 publications

References 9 publications

Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

Green Synthesis of Gold Nanoparticles Capped with Procyanidins from Leucosidea sericea as Potential Antidiabetic and Antioxidant Agents

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Physicochemical properties and in vitro stability studies of green synthesized gold nanoparticles using pelargonium sidoides

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