Photoswitchable Supramolecular Hydrogels Formed by Cyclodextrins and Azobenzene Polymers

Tamesue, Shingo; Takashima, Yoshinori; Yamaguchi, Hiroyasu; Shinkai, Seiji; Harada, Akira

doi:10.1002/anie.201003567

Cited by 419 publications

(262 citation statements)

References 58 publications

(34 reference statements)

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“…Self-thinning and self-healing properties of the gel were observed and as a result, an injectable hydrogel was obtained. 18 Furthermore, the non-covalent interaction enables the response of these soft materials to various stimuli, for example, light, [12][13][14] redox, 15,16 metal-ion 19 and temperature, 20 based on responsive guest molecules. Self-assembly of low molecular weight gelators (LMWGs), on the other hand, has also attracted considerable attention in the past decade.…”

mentioning

confidence: 99%

Hierarchical supramolecular hydrogels: self-assembly by peptides and photo-controlled release via host–guest interaction

Chu

Ravoo

2017

Chem. Commun.

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mentioning

confidence: 99%

Hierarchical supramolecular hydrogels: self-assembly by peptides and photo-controlled release via host–guest interaction

Chu

Ravoo

2017

Chem. Commun.

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“…When the sol was irradiated by visible light or heated, the sol turned back to a gel because of cis-to-trans isomerization. 44) Similarly, a polymer carrying Fc residues was mixed with that carrying βCD in forming a self-standing gel. When the gel was treated with an oxidizing agent, the gel turned into a sol.…”

Section: Stimuli-responsive Sol-gel Transitionmentioning

confidence: 99%

Supramolecular Polymeric Materials Containing Cyclodextrins

Nakahata

Takashima

Harada

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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Smart design of polymeric materials may lead to intelligent materials exhibiting unique functional properties. Looking at nature, living systems use specific and reversible intermolecular interactions in realizing complex functions. Hence reversible bonds based on selective molecular recognition can impart artificial materials with unique functional properties. This review mainly focuses on supramolecular polymeric materials based on cyclodextrin-based host-guest interactions. Polymeric materials using molecular recognition at polymer main chain, side chain, and termini are described. Polymers carrying host and guest residues exhibit unique properties such as: 1) formation of macroscopic self-assembly of polymer gels carrying host and guest residues; 2) stimuli-responsive self-healing properties due to the reversible nature of host-guest interactions; and 3) macroscopic motion of artificial muscle cross-linked by host-guest interaction controlled by external stimuli. An overview of recent developments in this new frontier between materials science and life science is given.

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“…Photochemical reaction and light-induced structural transformation can be completed within seconds or minutes by adjusting the parameters of external light source such as wavelength and intensity. [13][14][15] Recently, Kohane' group reported an example of photo-targeted nanoparticles. [ 16 ] This intelligent system was based on the photocaging method.…”

Section: Synthesis and Characterization Of Functional Accessorymentioning

confidence: 99%

Steric Protected and Illumination‐Activated Tumor Targeting Accessory for Endowing Drug‐Delivery Systems with Tumor Selectivity

Yuan

Zhao

et al. 2013

Adv Funct Materials

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Here, an ABA‐typed polymer, octadecyl‐polyethylene glycol (biotin)‐(o‐nitrobenzyl)‐octadecyl ester (CPB‐p‐C) with an o‐nitrobenzyl group inserted between polyethylene glycol (PEG) and octadecyl ester is synthesized as an illumination‐activated tumor targeting accessory for micelle‐based drug carriers. The functional accessory can form a flower‐like structure with folded PEG segments in aqueous solution to hide targeting biotin ligands in the core of the mixed micelle. Thus the specific binding between biotin and avidin can be suppressed by the steric hindrance of PEG shell. Upon illumination, the flower‐like structure of CPB‐p‐C is destroyed due to the cleavage of the o‐nitrobenzyl group and the biotin moieties are exposed on the surface of the micelle through the stretching process of PEG segments, generating ligand‐receptor‐mediated targeted delivery. By confocal laser scanning microscopy and flow cytometry, the illumination‐activated, tumor‐targeting delivery is studied. The influence of the amount of functional accessory in the mixed micelle on the targeting property is investigated and the optimal amount of CPB‐p‐C to achieve less side effects and better illumination activated tumor targeting activity is identified. The observed properties of CPB‐p‐C qualify it as a promising functional accessory to endow traditional drug‐delivery systems with tumor selectivity.

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Photoswitchable Supramolecular Hydrogels Formed by Cyclodextrins and Azobenzene Polymers

Cited by 419 publications

References 58 publications

Hierarchical supramolecular hydrogels: self-assembly by peptides and photo-controlled release via host–guest interaction

Hierarchical supramolecular hydrogels: self-assembly by peptides and photo-controlled release via host–guest interaction

Supramolecular Polymeric Materials Containing Cyclodextrins

Steric Protected and Illumination‐Activated Tumor Targeting Accessory for Endowing Drug‐Delivery Systems with Tumor Selectivity

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