2017
DOI: 10.1039/c7nr04403h
|View full text |Cite
|
Sign up to set email alerts
|

Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy

Abstract: Localization of the photosensitizer conjugation site in amphiphilic block copolymers is shown to have a great impact on photodynamic therapy efficiency. To this end, an asymmetric multifunctional derivative of the azadipyrromethene boron difluoride chelate (aza-BODIPY) was synthesized and inserted at specific locations in polypeptide-based rod-coil amphiphilic block copolymers. A study of the photophysical properties of the vesicle nanocarriers, obtained by self-assembly of these copolymers, as well as in vitr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
25
0

Year Published

2017
2017
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 30 publications
(25 citation statements)
references
References 58 publications
0
25
0
Order By: Relevance
“…Owing to their advantageous and tunable photophysical properties and ability to generate singlet oxygen ( 1 O 2 )c oupled with absorption of light from the socalled "therapeuticw indow"( 600 nm-1100 nm), aza-BODIPY dyes have been proposed as potential triplet photosensitizers for both anti-microbiala nd anti-cancer photodynamic therapy. [20,[30][31][32][33][34][35][36][37][38][39][40][41] Aza-BODIPYs continue to attracta ttention as chemosensors for the detection of ammonia, [42] cysteine, homocysteine and glutathione in living cells, [43] Hg 2 + , [44][45][46] F À , [47,48] in vivo detection of H 2 S, [49] carbon dioxide, [50] glucosei nw hole blood, [51] detection of saxitoxin [52] and pH-sensitive sensors. [52] Furthermore, aza-BODIPYs have been proposed as photoactive components in photovoltaic devices [54][55][56] and nonlinear optical materials.…”
Section: Introductionmentioning
confidence: 99%
“…Owing to their advantageous and tunable photophysical properties and ability to generate singlet oxygen ( 1 O 2 )c oupled with absorption of light from the socalled "therapeuticw indow"( 600 nm-1100 nm), aza-BODIPY dyes have been proposed as potential triplet photosensitizers for both anti-microbiala nd anti-cancer photodynamic therapy. [20,[30][31][32][33][34][35][36][37][38][39][40][41] Aza-BODIPYs continue to attracta ttention as chemosensors for the detection of ammonia, [42] cysteine, homocysteine and glutathione in living cells, [43] Hg 2 + , [44][45][46] F À , [47,48] in vivo detection of H 2 S, [49] carbon dioxide, [50] glucosei nw hole blood, [51] detection of saxitoxin [52] and pH-sensitive sensors. [52] Furthermore, aza-BODIPYs have been proposed as photoactive components in photovoltaic devices [54][55][56] and nonlinear optical materials.…”
Section: Introductionmentioning
confidence: 99%
“…As FCS only detects objects associated with PR-GFP, we could potentially detect different vesicle populations. Evidence for a good correlation of sizes obtained by DLS/FCS and micrographs haven been presented for liposomes 36,37 and PDMS-PMOXA polymersomes [38][39][40][41] , even though direct methods like (cryo-)TEM are considered more precise. The polydispersity index (PdI), obtained from cumulants analysis, was utilized as a measure for homogeneity.…”
Section: Resultsmentioning
confidence: 99%
“…Replacement of the meso‐carbon atom with an aza‐bridge results in a bathochromic shift of both absorption ( λ abs ) and emission ( λ fl ) bands of around 80 nm. Owing to their advantageous photophysical properties (triplet lifetimes τ T , triplet state quantum yields Φ T and triplet state energies E T ) combined with tunable singlet oxygen quantum yields (Φ Δ ) and ability to absorb light from the “therapeutic window”, aza‐BODIPYs have been proposed as potential triplet photosensitizers for both anti ‐microbial and anti ‐cancer photodynamic therapy . Furthermore, aza‐BODIPYs were considered as fluorescent chemosensors for the detection of ammonia, cysteine, homocysteine and glutathione in living cells, Hg 2+ , F − , in vivo detection of H 2 S and NO, carbon dioxide, glucose in whole blood and pH‐sensitive sensors .…”
Section: Introductionmentioning
confidence: 99%