Photosensitized Lipid Oxidation: Mechanisms and Consequences to Health Sciences

Bacellar, Isabel O. L.; Itri, Rosângela; Rodrigues, D. R.; Baptista, Maurício S.

doi:10.1007/978-3-030-87222-9_14

Cited by 2 publications

(2 citation statements)

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“…Lipid oxidation is a natural process that regularly occurs in cellular metabolism, being responsible for the synthesis of many biologically relevant molecules such as 4-hydroxyalkenals, for example, which are derived from the oxidation of polyunsaturated fatty acids (PUFAs), and oxysterols, which are derived from cholesterol oxidation. 666 Importantly, lipid oxidation is highly prevalent under redox distress conditions. Several reactive aldehydes and oxysterols, which are efficient electrophiles, react with abundant biological nucleophiles, such as sugars, lipids, proteins, and nucleic acids.…”

Section: β-Carotenementioning

confidence: 99%

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Endogenous Photosensitizers in Human Skin

2023

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Endogenous photosensitizers play a critical role in both beneficial and harmful light-induced transformations in biological systems. Understanding their mode of action is essential for advancing fields such as photomedicine, photoredox catalysis, environmental science, and the development of sun care products. This review offers a comprehensive analysis of endogenous photosensitizers in human skin, investigating the connections between their electronic excitation and the subsequent activation or damage of organic biomolecules. We gather the physicochemical and photochemical properties of key endogenous photosensitizers and examine the relationships between their chemical reactivity, location within the skin, and the primary biochemical events following solar radiation exposure, along with their influence on skin physiology and pathology. An important take-home message of this review is that photosensitization allows visible light and UV-A radiation to have large effects on skin. The analysis presented here unveils potential causes for the continuous increase in global skin cancer cases and emphasizes the limitations of current sun protection approaches.

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Section: β-Carotenementioning

confidence: 99%

“…Some products, such as acrolein, have been shown to produce singlet oxygen upon reaction with peroxynitrite . (c) Russell mechanism for the generation of singlet oxygen or triplet excited carbonyl compounds by recombination of hydroperoxyl radicals. , …”

Section: Key Endogenous Photosensitizers and Their Targetsmentioning

confidence: 99%