Photosensitization and the nervous system in the planarian Dugesia gonocephala

Palladini, Giovanni; Margotta, Vito; Medolago-Albani, L; Hernández, María Cristina; Carolei, Antonio; Michele, Teresa De

doi:10.1007/bf00239114

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…In contrast, it has been reported previously that the amount of DA was increased during the regeneration and DA antagonists (haloperidol and fluphenazine) delayed the regeneration in Polycelis tenuis (Franquinet, 1979), and that DA contributed to the screw-like hyperkinesia associated with photosensitization in Dugesia gonocephala s.l. (Palladini et al, 1981). In this study, our experiments using D. japonica were performed under the condition of normal brightness.…”

Section: Dopaminergic Regulation Of Locomotion and Behavior In Planarmentioning

confidence: 99%

“…In planarians, it has been previously reported that dopaminergic drugs induce behavioral changes in planarians. In brief, treatments with agonists for mammalian D1-and D2-dopaminergic receptors induced screw-like and C-like hyperkinesia, respectively (Algeri et al, 1983;Venturini et al, 1989;Palladini et al, 1996;Raffa et al, 2000Raffa et al, , 2001, and DA contributed to the screw-like hyperkinesia associated with photosensitization (Palladini et al, 1981). However, the existence of DA neurons in planarians has not been demonstrated yet by a genetic approach.…”

Section: Introductionmentioning

confidence: 98%

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Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates

Nishimura

Kitamura

Inoue³

et al. 2007

Developmental Neurobiology

131

127

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Planarian, an invertebrate flatworm, has a high capacity for regeneration when compared with other worms and animals. We show here for the first time that the reconstructed dopamine (DA) neural network regulates locomotion and behavior in planarian regenerates. The gene encoding tyrosine hydroxylase in the planarian Dugesia japonica (DjTH) was identified. DjTH protein was coexpressed with aromatic amino acid decarboxylase-like A (DjAADCA) in the planarian central nervous system (CNS). In addition, DjTH-knockdown planarians lost the ability to synthesize DA, but showed no change in 5-hydroxytryptamine synthesis. When the planarian body was amputated, DjTH-positive neurons were regenerated in the brain newly rebuilt from the tail piece at Day 3, and the DjTH-positive axonal and dendritic neural network in the CNS (dopaminergic tiara) was reconstructed at Days 5-7. At that time, autonomic locomotion and methamphetamine-induced hyperkinesia were also suppressed in DjTH-knockdown planarians. Planarian locomotion and behavior seem to be regulated in both cilia-and muscle-dependent manners. In DjTH-knockdown planarians, muscle-mediated locomotion and behavior were significantly attenuated. These results suggest that DA neurons play a key role in the muscle-mediated movement in planarians.

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Section: Dopaminergic Regulation Of Locomotion and Behavior In Planarmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates

Nishimura

Kitamura

Inoue³

et al. 2007

Developmental Neurobiology

131

127

View full text Add to dashboard Cite

show abstract

“…10.3389/fnmol.2022.935918 TABLE 1 Nomenclature of planarian noxious behaviors from the literature. Bardeen, 1901;Pearl, 1903Corning and Freed, 1968Welsh and Williams, 1970Carolei et al, 1975Palladini et al, 1981Algeri et al, 1983Venturini et al, 1989Kimmel and Carlyon, 1990Palladini et al, 1996…”

Section: Planarian Behavioral Metricsmentioning

confidence: 99%

Planarian nociception: Lessons from a scrunching flatworm

Reho

Lelièvre

Cadiou

2022

Front. Mol. Neurosci.

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In addition to being studied for their exceptional regeneration abilities, planarians (i.e., flatworms) have also been extensively used in the context of pharmacological experiments during the past century. Many researchers used planarians as a model system for the study of drug abuse because they display high similarities with the nervous system of vertebrates at cellular and molecular levels (e.g., neuronal morphology, neurotransmitter ligands, and receptor function). This research field recently led to the discovery of causal relationships between the expression of Transient Receptor Potential ion channels in planarians and their behavioral responses to noxious stimuli such as heat, cold or pharmacological analogs such as TRP agonists, among others. It has also been shown that some antinociceptive drugs modulate these behaviors. However, among the few authors that tried to implement a full behavior analysis, none reached a consensual use of the terms used to describe planarian gaits yet, nor did they establish a comprehensive description of a potential planarian nociceptive system. The aim of this review is therefore to aggregate the ancient and the most recent evidence for a true nociceptive behavior in planarians. It also highlights the convenience and relevance of this invertebrate model for nociceptive tests and suggests further lines of research. In regards to past pharmacological studies, this review finally discusses the opportunities given by the model to extensively screen for novel antinociceptive drugs.

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