Photosensitivity reaction to intravenously administered fluorescein

Lentner, A.; Böhler, U.

doi:10.1111/j.1600-0781.1995.tb00163.x

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…43,44 Patients also experience dizziness, headache, diarrhea, convulsions with bradycardia, circulatory problems, irritation at the injection site, vasovagal episodes (fainting), pruritus (itchy), urticaria (in 0.5% of patients with reactions), myocardial infarction, breathlessness, extravasation, thrombophlebitis (infl ammation of a clot in the superfi cial venous system), local tissue necrosis, laryngeal and facial edema, bronchospasm, and anaphylaxis and allergic reactions (in 0.5-1% of total patients). [43][44][45][46][47][48] The primary route of excretion is the kidney. 38 Cardiac arrest and death are very rare; the mortality rate is 0.0005%.…”

Section: Fluoresceinmentioning

confidence: 99%

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Toxicity of Organic Fluorophores Used in Molecular Imaging: Literature Review

et al. 2009

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Fluorophores are potentially useful for in vivo cancer diagnosis. Using relatively inexpensive and portable equipment, optical imaging with fluorophores permits real-time detection of cancer. However, fluorophores can be toxic and must be investigated before they can be administered safely to patients. A review of published literature on the toxicity of 19 widely used fluorophores was conducted by searching 26 comprehensive biomedical and chemical literature databases and analyzing the retrieved material. These fluorophores included Alexa Fluor 488 and 514, BODIPY FL, BODIPY R6G, Cy 5.5, Cy 7, cypate, fluorescein, indocyanine green, Oregon green, 8-phenyl BODIPY, rhodamine 110, rhodamine 6G, rhodamine X, rhodol, TAMRA, Texas red, and Tokyo green. Information regarding cytotoxicity, tissue toxicity, in vivo toxicity, and mutagenicity was included. Considerable toxicity-related information was available for the Food and Drug Administration (FDA)-approved compounds indocyanine green and fluorescein, but published information on many of the non-FDA-approved fluorophores was limited. The information located was encouraging because the amounts of fluorophore used in molecular imaging probes are typically much lower than the toxic doses described in the literature. Ultimately, the most effective and appropriate probes for use in patients will be determined by their fluorescent characteristics and the safety of the conjugates.

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Section: Fluoresceinmentioning

confidence: 99%

“…38 Cardiac arrest and death are very rare; the mortality rate is 0.0005%. 18,46 Fluorescein is a widely used, FDA-approved fl uorescent dye. Based on the existing data, it can have toxic effects in cell culture and on patients at high doses.…”

Section: Fluoresceinmentioning

confidence: 99%

Toxicity of Organic Fluorophores Used in Molecular Imaging: Literature Review

et al. 2009

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“…Ascaso et al (26) reported chest pain, dyspnea, diaphoresis, dropping of blood pressure and collapse with fatal outcome. Lentner and Bonier (27) reported pruritus and erythematous skin lesions considered as a photosensitivity reaction. Kirson and Wilson (28) reported a case of atrial fibrillation.…”

Section: Human Safety and Intravenous Injection Reports From The Clinicmentioning

confidence: 99%

Safety of sodium fluorescein for in vivo study of skin

O’goshi

Serup

2006

Skin Research and Technology

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Background/purpose: Epicutaneous labeling or intradermal injection of the fluorescent sodium fluorescein is being used increasingly to investigate skin conditions in vivo when using non‐invasive devices such as confocal scanning laser microscopy. Sodium fluorescein was used intravenously for decades for the examination of the vasculature of the ocular fundus (fluorescein angiography) and as eye drops for diagnosis of corneal erosions. The objective of this article is to systematically review the literature on fluorescein and conclude its safety in cutaneous research to support research planning and evaluations by ethics committees. Methods: A number of databases and the literature about safety and toxicity of fluorescein in animal and human studies were searched and analyzed. Results: Side effects or adverse events reported in the literature were related to intravenous bolus injection. Transient nausea and vomiting may occur. Other adverse events such as vasovagal reaction, cardiac or respiratory effects and anaphylaxes are extremely rare but may be fatal. Intradermal injection may cause mild itch or pain; systemic adverse event was reported. Epicutaneous labeling is associated with no reported problem. A typical local dose is several magnitudes of order smaller than a typical intravenous dose. Conclusion: Fluorescein has been used for many years in medicine for diagnostic purposes and is widely safe, albeit intravenous bolus injection may cause serious adverse reactions. In the literature, we could not trace reports of local or systemic side effects of topical sodium fluorescein except itch and pain on intradermal injection, however, dependent on the fluorescein preparation used. Local dermal application of fluorescein for in vivo study of skin may be considered widely safe.

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Fluorescence in Pharmaceutics and Cosmetics

Baptista

Bastos

2019

Springer Series on Fluorescence

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Photosensitivity reaction to intravenously administered fluorescein

Cited by 4 publications

References 18 publications

Toxicity of Organic Fluorophores Used in Molecular Imaging: Literature Review

Toxicity of Organic Fluorophores Used in Molecular Imaging: Literature Review

Safety of sodium fluorescein for in vivo study of skin

Fluorescence in Pharmaceutics and Cosmetics

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