Photoresponsive nanoparticles for drug delivery

Rwei, Alina Y.; Wang, Weiping; Kohane, Daniel S.

doi:10.1016/j.nantod.2015.06.004

Cited by 254 publications

(198 citation statements)

References 189 publications

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“…Most nanoparticles currently being used are successful by reducing side‐effects or as a means to solubilize hydrophobic drugs to induce fewer side effects 24. However, there has been significant preclinical work focused on developing new strategies for improving the delivery and efficacy of drugs using nanoparticles that are responsive to external stimuli such as heat,25, 26, 27, 28 light,29, 30, 31, 32, 33 ultrasound34 or tumor environment factors such as lower pH35, 36, 37, 38 or expression of certain enzymes 39, 40…”

Section: Introductionmentioning

confidence: 99%

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

et al. 2016

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Near infrared (NIR) light penetrates human tissues with limited depth, thereby providing a method to safely deliver non‐ionizing radiation to well‐defined target tissue volumes. Light‐based therapies including photodynamic therapy (PDT) and laser‐induced thermal therapy have been validated clinically for curative and palliative treatment of solid tumors. However, these monotherapies can suffer from incomplete tumor killing and have not displaced existing ablative modalities. The combination of phototherapy and chemotherapy (chemophototherapy, CPT), when carefully planned, has been shown to be an effective tumor treatment option preclinically and clinically. Chemotherapy can enhance the efficacy of PDT by targeting surviving cancer cells or by inhibiting regrowth of damaged tumor blood vessels. Alternatively, PDT‐mediated vascular permeabilization has been shown to enhance the deposition of nanoparticulate drugs into tumors for enhanced accumulation and efficacy. Integrated nanoparticles have been reported that combine photosensitizers and drugs into a single agent. More recently, light‐activated nanoparticles have been developed that release their payload in response to light irradiation to achieve improved drug bioavailability with superior efficacy. CPT can potently eradicate tumors with precise spatial control, and further clinical testing is warranted.

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Section: Introductionmentioning

confidence: 99%

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

et al. 2016

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“…Light has been especially attractive because of the ease with which it can be controlled (with respect to wavelength, power, and duration of irradiation) and because it has been used in clinical medicine (13). A large number of lighttriggerable drug-delivery systems has been reported (14)(15)(16), but relatively few have advanced as far as in vivo studies, in part because of limitations such as the poor tissue penetration of UV and visible light (16,17).…”

mentioning

confidence: 99%

Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes

Rwei

Lee

Zhan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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102

127

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Pain management would be greatly enhanced by a formulation that would provide local anesthesia at the time desired by patients and with the desired intensity and duration. To this end, we have developed near-infrared (NIR) light-triggered liposomes to provide on-demand adjustable local anesthesia. The liposomes contained tetrodotoxin (TTX), which has ultrapotent local anesthetic properties. They were made photo-labile by encapsulation of a NIR-triggerable photosensitizer; irradiation at 730 nm led to peroxidation of liposomal lipids, allowing drug release. In vitro, 5.6% of TTX was released upon NIR irradiation, which could be repeated a second time. The formulations were not cytotoxic in cell culture. In vivo, injection of liposomes containing TTX and the photosensitizer caused an initial nerve block lasting 13.5 ± 3.1 h. Additional periods of nerve block could be induced by irradiation at 730 nm. The timing, intensity, and duration of nerve blockade could be controlled by adjusting the timing, irradiance, and duration of irradiation. Tissue reaction to this formulation and the associated irradiation was benign.pain | site 1 sodium-channel blocker | photosensitizer | light | near infrared

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“…[55][56][57] Active-stimuli responsive drug release is a more precise and easily controllable strategy by using external stimuli. The design of these nanosystems usually takes advantage of photoactivated, [58] thermo-activated [59] and magnetic-activated materials [60] to achieve drug delivery under a specific external signal. Photoliable bonds or photoisomerization materials have been vastly investigated to fulfil the light inducible nanosystems.…”

Section: Second Generation Nanomedicinesmentioning

confidence: 99%

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

Balasubramanian

Liu

Hirvonen

et al. 2017

Adv Healthcare Materials

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Explosive growth of nanomedicines continues to significantly impact the therapeutic strategies for effective cancer treatment. Despite the significant progress in the development of advanced nanomedicines, successful clinical translation remains challenging. As cancer nanomedicine is a multidisciplinary field, the fundamental problem is that the knowledge gaps stem from different vantage points in the understanding of cancer nanomedicines. The complexities and heterogenecity of both nanomedicines and cancer are further demanding the integration of highly diverse expertise to develop clinically translatable cancer nanomedicines. This progress report aims to discuss the current understanding of cancer nanomedicines between different research areas in terms of nanoparticle engineering, formulation, tumor patho-physiology and clinical medicine, as well as to identify the knowledge gaps lying at the interface between the different fields of research in nanomedicine. Here we also highlight for the necessity to harmonize the multidisciplinary effort in the research of nanomedicines in order to bridge the knowledge and to advance the full understanding in cancer nanomedicines. A paradigm shift is needed in the strategic development of disease specific nanomedicines in order to foster the successful translation into clinic of future cancer nanomedicines.

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Photoresponsive nanoparticles for drug delivery

Cited by 254 publications

References 189 publications

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes

Bridging the Knowledge of Different Worlds to Understand the Big Picture of Cancer Nanomedicines

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