Photorespiration

Halliwell, Barry

doi:10.1016/0014-5793(76)80306-7

Cited by 9 publications

(2 citation statements)

References 56 publications

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“…suppression of DNA scission by free radical scavengers like mannitol or sodium benzoate (7). In view of the high reactivity of OH-(which is arguably the most powerful oxidant encountered in biological been shown to be quite slow (k < 0.3 M-' s-I) (37)(38)(39) and therefore is unlikely to represent the source of OH. species.…”

Section: Discussionmentioning

confidence: 99%

Evidence for the generation of free hydroxyl radicals from certain quinone antitumor antibiotics upon reductive activation in solution

Lown¹,

Chen²

1981

Can. J. Chem.

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This paper is dedicated to Prof. Raymond U . Lemieux on the occasion of his 60th birthday J. WILLIAM LOWN and HSIAO-HSIUNG CHEN. Can. J. Chem. 59,390 (1981). The nature of the reactive oxygen species generated from certain quinone antitumor antibiotics upon reductive activation in aqueous solution was investigated. A kinetic criterion was employed involving the relative rate of trapping of hydroxyl and formate radicals by the spin-trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) in conjunction with epr spectroscopy. By comparison with a system involving the photolysis of hydrogen peroxide as a standard free hydroxyl system it was concluded that at pH 7 and at 37'C reductive activation of adriamycin, daunorubicin, mitomycin B, mitomycin C, and streptonigrin gives rise to free hydroxyl radicals in direct contrast with, for example, the photolysis of quinones in solution.

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Section: Discussionmentioning

confidence: 99%

Evidence for the generation of free hydroxyl radicals from certain quinone antitumor antibiotics upon reductive activation in solution

Lown¹,

Chen²

1981

Can. J. Chem.

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“…This conference marked the end of the first 3‐year period of PROMICS (Photorespiration: Origins and Metabolic Integration in Interacting Compartments), which is a generously supported research unit of the German Research Foundation. Historically, this conference was the first international meeting specifically devoted to photorespiration since 1976 (Halliwell ). We very much appreciate that the many colleagues who attended this conference also contributed to this special issue.…”

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confidence: 99%