Photoprotective activity of resveratrol analogues

Cosmetic Potential of a Liotropic Liquid Crystal Emulsion Containing Resveratrol

“…Resveratrol dosing was chosen based on previous works from our group [4,10], which report biological activities at 10% (w/w), when used topically instead of orally. Resveratrol was measured, and soon thereafter, it was transferred to a porcelain mortar and pestle.…”

“…Traditional products with resveratrol have already been proved to minimally act against lipid peroxidation [8], as skin-lightening agent [8][9][10][11] and as photoprotective agent [7][8][9][10]. In this case, it seems that its incorporation into traditional topical dosage forms is more efficient than in liotropic liquid crystal emulsions.…”

“…It has demonstrated great potential for use as a more efficient means to combat lipid peroxidation when compared with vitamins C and E (95%, 65%, and 37%, respectively) [8]. Besides its antioxidant effect, resveratrol has been reported to be an important selective inhibitor of tyrosine kinase, a key melanogenesis catalyst enzyme, suggesting that it can also be used as a skin-lightening agent [8][9][10][11]. Recent studies have shown that this substance has an important photoprotective effect once it acts on cell signaling mechanisms related to photoaging caused by ultraviolet radiation (UVA and UVB rays) [7][8][9][10].…”

“…Besides its antioxidant effect, resveratrol has been reported to be an important selective inhibitor of tyrosine kinase, a key melanogenesis catalyst enzyme, suggesting that it can also be used as a skin-lightening agent [8][9][10][11]. Recent studies have shown that this substance has an important photoprotective effect once it acts on cell signaling mechanisms related to photoaging caused by ultraviolet radiation (UVA and UVB rays) [7][8][9][10]. According to Polonini et al, when applied topically, the chemopreventive, antiproliferative, and photoprotective properties of resveratrol are emphasized [4].…”

“…Liquid crystal systems are more stable when compared with other emulsions because they promote higher cutaneous hydration by retaining water in the corneal layer and delivering the sustained release of active ingredients to target areas. When the chemical structure is compared with the composition and disposition of both lipids and water present in the epidermis, an emulsion is the best option to address cutaneous issues in the cosmetic field, in particular, as an antiaging treatment [9][10][11][12][13][14].…”