Photoprotection by topical application of Achyrocline satureioides (‘Marcela’)

Abstract

It has been demonstrated that the use of topical antioxidants can contribute to controling the free radicals excess produced by ultraviolet (UV) irradiation of the skin, being beneficial for processes such as photo aging and eventually cancer. Some plant extracts, particularly because of their polyphenolic constituents, can be beneficial for skin photo damage. Plant extracts of Achyrocline satureioides (AS) and Epilobium parviflorum (EP), potent antioxidant medicinal plants, were mixed with a cosmetic base and applied to the back skin of rabbits. Afterwards the skin was exposed to 1 h of UV irradiation from a known source. The production of the hydroxyl (OH.) radical was assessed in the skin after UV by measuring 2,3-dyhydroxybenzoic acid (2,3-DHBA), produced by the hydroxylation of sodium salicylate, previously injected intracutaneously (i.c.) in the irradiated areas. The UV provoked a marked increase in 2,3-DHBA that was significantly decreased by the AS cosmetic preparation. The EP extract did not show any effect on 2,3-DHBA production. It is concluded that the cosmetic preparation containing the AS extract is able to scavenge OH. production likely to be due to the presence of high concentrations of flavonoid aglycones such as quercetin, luteolin and 3-O-methylquercetin.

Intraperitoneally administered biliverdin protects against UVB-induced skin photo-damage in hairless mice

“…The strong antioxidant properties of BVD have been shown in other experimental models, including inflammation, ischemia-reperfusion injury and transplantation [15][16][17][18][19]. The regular intake of dietary antioxidants or topical treatment of the skin with products containing antioxidant ingredients has been suggested as a useful strategy to prevent UV-mediated cutaneous damage [20][21][22]. Therefore, we hypothesize that BVD administration would significantly protect against UVB-induced skin photo-damage in humans.…”

The Flavonoid Luteolin Increases the Resistance of Normal, but Not Malignant Keratinocytes, Against UVB-Induced Apoptosis

“…These natural compounds show strong antioxidant effects and some also show other biochemical effects in human cells, such as enzyme inhibition, anti-inflammatory, and anticarcinogenic capacities (Nijveldt et al, 2001). These characteristics make flavonoids potent candidates for photoprotective applications (Morquio et al, 2005;Afaq and Mukhtar, 2006;Verschooten et al, 2006a).…”

“…Furthermore, LUT has been shown to have anti-inflammatory effects (Gutierrez-Venegas et al, 2006) and even anticancer activity through interference with several signaling pathways, such as mitogen-activated protein kinase, NF-kB, PI3K/AKT (phosphatidylinositol-3-kinase/ acutely transforming retrovirus AKT8 in rodent T cell lymphoma) (Lin et al, 2008), and the specific induction of apoptosis (Ramos, 2007). The topical application of Achyrocline satureioides and perilla leaf extract, both containing a significant amount of LUT, inhibited UV-induced reactive oxygen species (ROS) formation in rabbits (Morquio et al, 2005) and 12-O-tetradecanoylphorbol-3-acetate (TPA)-induced tumor formation in mice (Ueda et al, 2003), respectively. A very recent study, in which a LUT-rich Reseda extract was applied to human skin before UVB irradiation, showed the potential of LUT in the prevention of UVB-induced erythema (Casetti et al, 2009).…”

Multiple emulsions containing amazon oil: açaí oil (Euterpe oleracea)

“…Previous studies have presented evidence for the ability of extracts and vegetable oils to provide UV absorption or photoprotection (Katiyar & Elmets, 2001;Moquio et al, 2005;Souza et al 2005;Ferrari et al, 2007;2008;Velasco et al, 2008;Violante et al, 2008;Violante et al, 2009).…”