Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

Park, Yongdoo; Tirelli, Nicola; Hubbell, Jeffrey A.

doi:10.1016/s0142-9612(02)00420-9

Cited by 370 publications

(174 citation statements)

References 26 publications

Supporting

Mentioning

171

Contrasting

Unclassified

Order By: Relevance

“…4) glycoside bonding. As a weak polyelectrolyte with pKa at 2.9, HA demonstrates a relatively low charge density even when its all carboxylic acid groups are ionized since only one unit from the two in its monomer has an ionizable group [22,23]. HA has been widely used in biomedicine, tissue engineering, drug delivery because of its good biocompatibility, nontoxicity and its hydrogel membrane [24].…”

Section: Introductionmentioning

confidence: 99%

Direct Electrochemistry of Hemoglobin and Its Electrocatalysis Based on Hyaluronic Acid and Room Temperature Ionic Liquid

et al. 2008

View full text Add to dashboard Cite

A biocomposite material of hyaluronic acid (HA) and room temperature ionic liquid, 1-butyl-3-methyl-imidazolium tetrafluoroborate (BMIMBF 4 ) was fabricated and characterized by voltammetry and electrochemical impedance spectroscopy. Hemoglobin (Hb), as a model protein, was immobilized in this biocomposite on glassy carbon electrode to investigate its direct electrochemistry. A pair of well-defined, quasireversible cyclic voltammetric peaks appeared with the formal potentials (E8') at À 0.360 V (vs. SCE). The Hb modified electrode exhibited an excellent electrocatalytic activity to the reduction of H 2 O 2 with a wide linear range, good selectivity, sensitivity and reproducibility, which had potential application to fabrication the third-generation biosensor.

show abstract

Section: Introductionmentioning

confidence: 99%

Direct Electrochemistry of Hemoglobin and Its Electrocatalysis Based on Hyaluronic Acid and Room Temperature Ionic Liquid

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Rather than using ECM consisting primarily of a single component that either permits or restricts cell spreading and migration, [10] we hypothesized that the structural properties of a two-component ECM [11][12][13] -in which one component acts as a stable structural element and another component gels or dissolves -could be dynamically modified (Fig. 1A).…”

mentioning

confidence: 99%

Dynamic Hydrogels: Switching of 3D Microenvironments Using Two‐Component Naturally Derived Extracellular Matrices

et al. 2010

View full text Add to dashboard Cite

“…Properties that make the linear polymer HA a desirable biomaterial include (1) the ability to control molecular weight through degradation; (2) the ability to remodel it by proteases secreted from specific cell types; (3) its capacity to be functionalized with desirable GFs and other biomacromolecules; (4) its ability to undergo crosslinking to form hydrogels; and (5) the modifiability of its adhesion properties through functional groups or hybrid materials [207] .…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Stem Cells and Scaffolds for Vascularizing Engineered Tissue Constructs

Luong

Gerecht

2008

Engineering of Stem Cells

View full text Add to dashboard Cite

The clinical impact of tissue engineering depends upon our ability to direct cells to form tissues with characteristic structural and mechanical properties from the molecular level up to organized tissue. Induction and creation of functional vascular networks has been one of the main goals of tissue engineering either in vitro, for the transplantation of prevascularized constructs, or in vivo, for cellular organization within the implantation site. In most cases, tissue engineering attempts to recapitulate certain aspects of normal development in order to stimulate cell differentiation and functional tissue assembly. The induction of tissue growth generally involves the use of biodegradable and bioactive materials designed, ideally, to provide a mechanical, physical, and biochemical template for tissue regeneration. Human embryonic stem cells (hESCs), derived from the inner cell mass of a developing blastocyst, are capable of differentiating into all cell types of the body. Specifically, hESCs have the capability to differentiate and form blood vessels de novo in a process called vasculogenesis. Human ESC-derived endothelial progenitor cells (EPCs) and endothelial cells have substantial potential for microvessel formation, in vitro and in vivo. Human adult EPCs are being isolated to understand the fundamental biology of how these cells are regulated as a population and to explore whether these cells can be differentiated and reimplanted as a cellular therapy in order to arrest or even reverse damaged vasculature. This chapter focuses on advances made toward the generation and engineering of functional vascular tissue, focusing on both the scaffolds - the synthetic and biopolymer materials - and the cell sources - hESCs and hEPCs.

show abstract

Photopolymerized hyaluronic acid-based hydrogels and interpenetrating networks

Cited by 370 publications

References 26 publications

Direct Electrochemistry of Hemoglobin and Its Electrocatalysis Based on Hyaluronic Acid and Room Temperature Ionic Liquid

Direct Electrochemistry of Hemoglobin and Its Electrocatalysis Based on Hyaluronic Acid and Room Temperature Ionic Liquid

Dynamic Hydrogels: Switching of 3D Microenvironments Using Two‐Component Naturally Derived Extracellular Matrices

Stem Cells and Scaffolds for Vascularizing Engineered Tissue Constructs

Contact Info

Product

Resources

About