Photopolymerization of hydrogels for cartilage tissue engineering

Uttayarat, Pimpon; Boonsirichai, Kanokporn; Tangthong, Theeranan; Pimton, Pimchanok; Thongbopit, Sasiprapa; Phermthai, Tatsanee

doi:10.1109/bmeicon.2015.7399526

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…The high water content of hydrogels gives the materials advantages in biomedical application as it contributes to biocompatible property and minimal tendency to cause irritation [3][4][5]. Due to the ability to imbibe and retain a lot of water within their matrices without compromising structural integrity, hydrogels have been extensively used as contact lens [1,[6][7][8], drug delivery systems, wound dressings [1,6,[8][9][10][11][12][13], and tissue-engineered scaffolds [3][4][5][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Processing and Characterization of Antibacterial Hydrogel Sheet Dressings Composed of Poly(vinyl alcohol) and Silk Fibroin for Wound Healing Application

Uttayarat¹,

Chiangnoon²,

Eamsiri³

et al. 2018

Walailak J Sci & Tech

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Hydrogels are soft materials that contain high water content within their 3-dimensional structure. Such extremely hydrated environment allows hydrogels to recapitulate the structure of many native tissues inside the body. In biomedical application, hydrogels have been extensively used as biocompatible materials, drug delivery systems, and tissue-engineered scaffolds that can be designed to possess either permanent or slow-degradation properties. In this research, we applied gamma irradiation to develop transparent and conformal hydrogel sheets with sufficient mechanical strength from poly(vinyl alcohol) (PVA) and further modified the based PVA matrix with naturally-derived silk fibroin (SF) protein and silver nitrate (AgNO3) for wound healing purpose. The physical and mechanical properties of based PVA hydrogels formed at varied irradiation doses from 10 - 80 kGy were first characterized. The dose of 60 kGy was found to be optimal to process flexible and elastic PVA sheets with equilibrium degree of swelling of 1000 %, gel fraction of 90 %, and tensile strength of 19 kPa. To further enhance water absorption capacity, 10 - 40 % (w/w) silk fibroin was added to the based PVA matrix. Based on water absorption and gel fraction data, hydrogel sheets with 8PVA:2SF formulation was selected for antibacterial test. Disc diffusion assay showed that the incorporation of 0.4 mM AgNO3 in 8PVA:2SF hydrogel sheets could inhibit the growth of Staphyllococcus aureus and Pseudomonas aeruginosa. These results demonstrated that a prototypic, antibacterial hydrogel sheet dressing composed of both synthetic and natural polymers could be developed within a single-step by gamma irradiation technique.

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Section: Introductionmentioning

confidence: 99%

Processing and Characterization of Antibacterial Hydrogel Sheet Dressings Composed of Poly(vinyl alcohol) and Silk Fibroin for Wound Healing Application

Uttayarat¹,

Chiangnoon²,

Eamsiri³

et al. 2018

Walailak J Sci & Tech

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“…However, repairing the cartilage in this way does not involve curved surface forming, whereas in actual tissue repair, curved surface forming is unavoidable. Other studies on in-situ cartilage repair, using injection [5] or pouring [6] methods to fill the defects, demonstrate uncertain forming precision due to their manual operation.…”

Section: Introductionmentioning

confidence: 99%

Development of a Robotic Arm Based Hydrogel Additive Manufacturing System for In-Situ Printing

Xiao

Lian

et al. 2017

Applied Sciences

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Abstract:In-situ printing is a promising injury repair technique that can be directly applied during surgical operations. This paper features a potential in-situ printing platform based on a small-scale robotic arm with a micro-sized dispenser valve. A double-light-source curing method was applied to print poly(ethylene glycol) diacrylate (PEGDA) with a 20% (weight/volume) ratio and the entire process was controlled automatically by a computer interface where droplet diameter, curing time, mechanical properties were measured and essential printing parameters (e.g., nozzle velocity, nozzle frequency) were determined. Three different two-dimensional (2D) plane models (namely, square, circular, and heart-shaped) were printed during initial printing trials. The feasibility study of in-situ printing on curved surfaces was tested using a three-dimensional (3D) printed defect model. The defect was successfully filled using both parallel and ring printing paths. In conclusion, the robotic arm printing platform and its forming method can achieve a rapid curing of PEGDA hydrogel on a curved surface and has the potential to be applied to in-situ printing.

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Emerging therapies for cartilage regeneration in currently excluded ‘red knee’ populations

et al. 2019

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The field of articular cartilage repair has made significant advances in recent decades; yet current therapies are generally not evaluated or tested, at the time of pivotal trial, in patients with a variety of common comorbidities. To that end, we systematically reviewed cartilage repair clinical trials to identify common exclusion criteria and reviewed the literature to identify emerging regenerative approaches that are poised to overcome these current exclusion criteria. The term "knee cartilage repair" was searched on clinicaltrials.gov. Of the 60 trials identified on initial search, 33 were further examined to extract exclusion criteria. Criteria excluded by more than half of the trials were identified in order to focus discussion on emerging regenerative strategies that might address these concerns. These criteria included age (<18 or >55 years old), small defects (<1 cm 2), large defects (>8 cm 2), multiple defect (>2 lesions), BMI >35, meniscectomy (>50%), bilateral knee pathology, ligamentous instability, arthritis, malalignment, prior repair, kissing lesions, neurologic disease of lower extremities, inflammation, infection, endocrine or metabolic disease, drug or alcohol abuse, pregnancy, and history of cancer. Finally, we describe emerging tissue engineering and regenerative approaches that might foster cartilage repair in these challenging environments. The identified criteria exclude a majority of the affected population from treatment, and thus greater focus must be placed on these emerging cartilage regeneration techniques to treat patients with the challenging "red knee".

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Photopolymerization of hydrogels for cartilage tissue engineering

Cited by 4 publications

References 6 publications

Processing and Characterization of Antibacterial Hydrogel Sheet Dressings Composed of Poly(vinyl alcohol) and Silk Fibroin for Wound Healing Application

Processing and Characterization of Antibacterial Hydrogel Sheet Dressings Composed of Poly(vinyl alcohol) and Silk Fibroin for Wound Healing Application

Development of a Robotic Arm Based Hydrogel Additive Manufacturing System for In-Situ Printing

Emerging therapies for cartilage regeneration in currently excluded ‘red knee’ populations

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