Photopolymerization and photostructuring of molecularly imprinted polymers for sensor applications—A review

Fuchs, Yannick; Soppera, Olivier; Haupt, Karsten

doi:10.1016/j.aca.2011.12.026

Cited by 195 publications

(123 citation statements)

References 92 publications

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“…Structuring MIPs at the micro-and nano-scale increases the recognition surface available, greatly improving the site accessibility of imprinted materials. 2 Implementation of MIP-based nanosensor architectures requires the formation of MIP micro-and nanofeatures with well-dened morphologies onto the surface of particular devices (e.g. transducers) and/or planar substrates (e.g.…”

Section: Introductionmentioning

confidence: 99%

Molecular recognition with nanostructures fabricated by photopolymerization within metallic subwavelength apertures

et al. 2014

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The first demonstration of fabrication of submicron lateral resolution molecularly imprinted polymer (MIP) patterns by photoinduced local polymerization within metal subwavelength apertures is reported. The size of the photopolymerized MIP features is finely tuned by the dose of 532 nm radiation. Rhodamine 123 (R123) has been selected as a fluorescent model template to prove the recognition capability of the MIP nanostructures, which has been evaluated by fluorescence lifetime imaging microscopy (FLIM) with single photon timing measurements. The binding selectivity provided by the imprinting effect has been confirmed in the presence of compounds structurally related to R123. These results pave the way to the development of nanomaterial architectures with biomimetic artificial recognition properties for environmental, clinical and food testing.

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Section: Introductionmentioning

confidence: 99%

Molecular recognition with nanostructures fabricated by photopolymerization within metallic subwavelength apertures

et al. 2014

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“…MIPs have been most often synthesized on the sensor surface in situ in the form of bulk polymer fi lms by using thermal or photo-initiated polymerization in the presence of template molecules. [ 11,12 ] However, this approach provides only limited density of accessible binding sites in close proximity to the outer surface of the MIP layer, which impedes the sensor sensitivity. In order to provide a more open structure, which can carry higher amounts of binding sites that are available for capture of diffusing target analyte, there were investigated MIP fi lms, which were structured by using sacrifi cial colloidal crystals [ 9,13 ] and optical lithography [ 12 ] or formed by imprinting of loosely crosslinked hydrogels.…”

Section: Introductionmentioning

confidence: 99%

“…[ 11,12 ] However, this approach provides only limited density of accessible binding sites in close proximity to the outer surface of the MIP layer, which impedes the sensor sensitivity. In order to provide a more open structure, which can carry higher amounts of binding sites that are available for capture of diffusing target analyte, there were investigated MIP fi lms, which were structured by using sacrifi cial colloidal crystals [ 9,13 ] and optical lithography [ 12 ] or formed by imprinting of loosely crosslinked hydrogels. [ 14 ] These systems were reported to be capable of direct detection of small molecular analytes at typically μM-mM concentrations; [ 3 ] however, several works reported the limit of detection at as low as pM concentrations.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low‐Molecular‐Weight Analytes

Sharma

Petri

Jonas

et al. 2014

Macro Chemistry & Physics

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New composite layer architecture of 3D hydrogel polymer network that is loaded with molecularly imprinted polymer nanoparticles (nanoMIP) is reported for direct optical detection of low-molecular-weight compounds. This composite layer is attached to the metallic surface of a surface plasmon resonance (SPR) sensor in order to simultaneously serve as an optical waveguide and large capacity binding-matrix for imprinted target analyte. Optical waveguide spectroscopy (OWS) is used as a labelfree readout method allowing direct measurement of refractive index changes that are associated with molecular binding events inside the matrix. This approach is implemented by using a photocrosslinkable poly( N -isopropylacrylamide)-based hydrogel and poly[(ethylene glycol dimethylacrylate)-(methacrylic acid)] nanoparticles that are imprinted with L -Boc-phenylalanine-anilide ( L -BFA, molecular weight 353 g mol −1 ). Titration experiments with the specifi c target and other structurally similar reference compounds show good specifi city and limit of detection for target L -BFA as low as 2 × 10 −6 M .

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“…The target analytes will be separated from coexisting substances and selectively adsorbed on the MIPs materials, followed by detection [19]. Because of its attractive selectivity, high mechanical and thermal stability, high adsorption capacity, as well as low cost and easy operation, MIPs have received extensive concerns and been widely applied in many fields, such as extraction separation [20,21], removal [22] and chemo/biosensors [23,24]. A number of studies for amino acids based on MIPs have been rapidly carried out.…”

Section: Introductionmentioning

confidence: 99%

Chemodosimeter-based fluorescent detection of l-cysteine after extracted by molecularly imprinted polymers

Cai

Zhong

et al. 2014

Talanta

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Chemodosimeter Rhodamine B a b s t r a c tA chemodosimeter-based fluorescent detection method coupled with molecularly imprinted polymers (MIPs) extraction was developed for determination of L-cysteine (L-Cys) by combining molecular imprinting technique with fluorescent chemodosimeter. The MIPs prepared by precipitation polymerization with L-Cys as template, possessed high specific surface area of 145 m 2 /g and good thermal stability without decomposition lower than 300 1C, and were successfully applied as an adsorbent with excellent selectivity for L-Cys over other amino acids, and enantioselectivity was also demonstrated. A novel chemodosimeter, rhodamine B1, was synthesized for discriminating L-Cys from its structurally similar homocysteine and glutathione as well as various possibly co-existing biospecies in aqueous solutions with notable fluorescence enhancement when adding L-Cys. As L-Cys was added with increasing concentrations, an emission band peaked at 580 nm occurred and significantly increased in fluorescence intensity, by which the L-Cys could be sensed optically. High detectability up to 12.5 nM was obtained. An excellent linearity was found within the wide range of 0.05-50 μM (r¼ 0.9996), and reasonable relative standard deviations ranging from 0.3% to 3.5% were attained. Such typical features as high selectivity, high sensitivity, easy operation and low cost enabled this MIPs-fluorometry to be potentially applicable for routine detection of trace L-Cys.

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Photopolymerization and photostructuring of molecularly imprinted polymers for sensor applications—A review

Cited by 195 publications

References 92 publications

Molecular recognition with nanostructures fabricated by photopolymerization within metallic subwavelength apertures

Molecular recognition with nanostructures fabricated by photopolymerization within metallic subwavelength apertures

Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low‐Molecular‐Weight Analytes

Chemodosimeter-based fluorescent detection of l-cysteine after extracted by molecularly imprinted polymers

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