Photophysics of J-Aggregating Porphyrin-Lipid Photosensitizers in Liposomes: Impact of Lipid Saturation

Charron, Danielle M.; Yousefalizadeh, Goonay; Buzzá, Hilde Harb; Rajora, Maneesha A.; Chen, Juan; Stamplecoskie, Kevin G.; Zheng, Gang

doi:10.1021/acs.langmuir.0c00843

Cited by 33 publications

(38 citation statements)

References 51 publications

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“…Side-by-side aggregation of porphyrin layers results in a blue shift toward 408 nm, known as sandwich-type H-aggregation. From all the above-mentioned results, it can be concluded that the self-assembled nanoparticle demonstrates simultaneously both J-and H-aggregations in the self-assembled system 35,36 . In another test, UV-Vis analysis of the polymersome was carried out before and after irradiating UV.…”

Section: Formation Of Polymersomementioning

confidence: 86%

The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome

Sajadi

Khoee

2021

Sci Rep

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Aggregation-induced quenching of porphyrin molecules as photosensitizer significantly reduces the quantum yield of the singlet oxygen generation, and it is able to decrease the efficacy of photodynamic therapy. We utilized amphiphilic copolymers in this work to precisely control porphyrin H-type and J-type aggregations in water. The amphiphilic copolymer bearing azobenzene, β-cyclodextrin, and porphyrin was successfully synthesized by the atom transfer radical polymerization technique. The azobenzene and β-cyclodextrin complex, as a host–guest supramolecular interaction, has great potential in the design of light-responsive nanocarriers. The amphiphilic block copolymer can be self-assembled into polymersomes, whose application in the generation of singlet oxygen has been also tested. We further demonstrate that, due to the stable H- and J-aggregates of porphyrin, which act as noncovalent cross-linking points, the structure of polymersomes can be reversible under light-stimulus. This formation method has the advantage of allowing for both the encapsulation of hydrophilic and hydrophobic molecules and release upon external light without any distinguishable changes in the structure. Furthermore, the morphology and particle size distribution of the polymersomes were also investigated by using transition electron microscopy, dynamic light scattering, and field emission scanning electron microscopy.

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Section: Formation Of Polymersomementioning

confidence: 86%

The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome

Sajadi

Khoee

2021

Sci Rep

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“…[ 18 ] Particularly, near‐infrared (NIR) light with deep tissue penetration is favorable in various biomedical applications such as optical imaging, [ 19 ] photoregulation, [ 20 ] and phototherapy including photothermal therapy (PTT) [ 21 ] and photodynamic therapy (PDT). [ 22 ] Among various phototheranostic agents such as carbon nanotubes, [ 23 ] silica nanoparticles, [ 24 ] metal–organic framework (MOF) nanoparticles, [ 25 ] 2D materials, [ 26 ] and porphyrin nanoparticles, [ 7c,27 ] semiconducting polymer nanoparticles (SPNs) with benefits of adjustable optical properties, high biocompatibility, and high chemical flexibility have shown great potential in light‐controllable regulation of biological events. [ 28 ] We have shown that NIR light‐absorbing SPNs have been developed for NIR regulation of gene editing, [ 29 ] remote activation of nanoenzymes, [ 30 ] and controlled delivery of indoleamine 2,3‐dioxygenase (IDO) inhibitors.…”

Section: Figurementioning

confidence: 99%

Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

et al. 2020

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In particular, activatable immunotherapeutic nanoplatforms have received tremendous attention as these nanomedicines can exert immunotherapeutic action only in response to certain stimuli, which largely promoted the specificity and controllability of immunotherapeutic response at designated sites. [7] On account of the restricted immune cell infiltration and dysfunction of immune cells by metabolic stress, [8] modulation of cancer metabolic pathways with immunotherapeutic drugs to reprogramme the tumor immune microenvironment has emerged as a promising approach, namely, immunometabolic cancer therapy. [9] Modulation of lactic acid production, [10] inhibition of glutamine catabolism, [11] and suppression of tryptophan catabolism [12] represent some attractive targets for immunometabolic intervention and tumor suppression. Till now, several small-molecule inhibitors have been developed for immunometabolic intervention and entered clinical testing, such as navoximod (also known as NLG919), HTI-1090 (also known as SHR9146), and DN1406131. [13] However, small-molecule inhibitors are commonly unable to maintain sustainable immune response and suffer from drug resistance and some adverse side effects, which hinders their therapeutic efficacy in the modulation of immunometabolism. [14] In contrast to small-molecule inhibitors, enzyme immunotherapeutics possess highly selective capabilities in catalyzing shifts in the local availability of immunostimulatory and immunosuppressive signals. [15] Additionally, enzyme treatment eliminates immunosuppressive metabolite irrespective of different pathways and alleviates concerns of mutation and the drug resistance, thus overpassing many limitations of small-molecule inhibitors. [16] However, the clinical success of enzyme immunotherapeutics frequently hinges upon achieving sustained biocatalysis over relevant time scales at the designated site owing to rapid clearance enzyme degradation via proteases and insufficient accumulation at target tissues. [17] Therefore, the integration of enzyme immunotherapeutics with activable nanoplatforms could be a promising strategy to address these issues. Among a variety of stimuli for remote control, light has served as a paradigm for noninvasiveness, high spatial-temporal controllability, and low toxicity. [18] Particularly, near-infrared

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“…Porphyrin‐lipid J‐aggregates are photostable with a photothermal efficiency of 54 ± 6%, and disordered aggregates are photodynamically active. [ 76 ] In other cases, the J‐aggregation of dye possessed all features of red shifted fluorescence emission, photodynamic ability, and photothermal conversion. [ 48a ] The phenomenon was attributed to the balance of radiative decay, ISC, and heat generation‐related photophysical processes.…”

Section: Aggregation Enhanced Photodynamic/photothermal Effect For Phototherapymentioning

confidence: 99%

Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

Lai

et al. 2021

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Phototheranostics provide a safe, effective, and noninvasive way for the diagnosis and treatment of contemporary diseases, and organic dyes play a vital role. For example, chemical modification endowed dyes with powerful reactive oxygen species or heat generation ability, favoring for photodynamic therapy and photoacoustic (PA) imaging guided photothermal therapy (PTT) of serious diseases. Therefore, photophysical properties manipulation of dyes has become the focus in current dye chemistry research. The development of aggregate science has made great effort to solve this problem. In recent years, a large number of studies have focused on molecular aggregation behavior and its effect on photophysical performance. The most famous example is the discovery of aggregation‐induced emission (AIE) phenomenon. Based on AIE theory, more theories for revealing the relationship between molecular aggregation behavior and photophysical properties were proposed and elucidated. The photophysical property changes caused by dye aggregation have become a unique discipline, guiding the development of molecular science and material science. With the help of molecular self‐assembly, controllable aggregation of dyes can be realized, and stable nano‐theranostic reagents can be obtained. Furthermore, constructing dye assemblies with various photophysical properties will greatly reduce the cost of theranostic reagents, thus, expanding biomedical applications of organic dyes. Therefore, this review focuses on the photophysical characteristic changes caused by dye aggregation and their biological applications including, fluorescence/phosphorescence/PA imaging as well as photodynamic and PTT. This review will provide guidance for the design of organic dyes, the development of controllable aggregation methods, and the construction of multifunctional phototheranostic reagents.

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Photophysics of J-Aggregating Porphyrin-Lipid Photosensitizers in Liposomes: Impact of Lipid Saturation

Cited by 33 publications

References 51 publications

The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome

The simultaneous role of porphyrins’ H- and J- aggregates and host–guest chemistry on the fabrication of reversible Dextran-PMMA polymersome

Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

Organic dye assemblies with aggregation‐induced photophysical changes and their bio‐applications

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