Photon-Manipulated Drug Release from a Mesoporous Nanocontainer Controlled by Azobenzene-Modified Nucleic Acid

Yuan, Quan; Zhang, Yunfei; Chen, Tao; Lu, Danqing; Zhao, Zilong; Zhang, Xiaobing; Liu, Zhenxing; Yan, Chun‐Hua; Tan, Weihong

doi:10.1021/nn3018365

Cited by 228 publications

(175 citation statements)

References 35 publications

(52 reference statements)

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“…In this context, the biocompatibility of the photochromic/hydrophobic and hydrophilic components is an important design criterion for the synthesis of photo-responsive biopolymeric micelles [52]. Hu et al [25] and Yuan et al [53] have demonstrated that azobenzene-modified amphiphilic copolymers and DNA-azobenzene conjugates are biocompatible. In contrast to Yuan et al, we used only one azobenzene group for each oligonucleotide chain which will further minimize biocompatibility issues.…”

Section: Photocontrolled Micellization Of Dna-azobenzene Conjugatementioning

confidence: 99%

Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates

Lamas

Rastogi

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Photocontrolled Micellization Of Dna-azobenzene Conjugatementioning

confidence: 99%

Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates

Lamas

Rastogi

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…One such example is the photo-induced release of Dox that was achieved through incorporation of photoswitchable azobenzenes in the capping DNA (Fig. 17B) [141]. In the absence of light these moieties are in a trans-configuration and therefore allow for hybridization of two DNA strands.…”

Section: Nps Composed Of Silica and Dnamentioning

confidence: 99%

Drug delivery systems based on nucleic acid nanostructures

Vries

Zhang

Herrmann

2013

Journal of Controlled Release

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a b s t r a c t a r t i c l e i n f oThe field of DNA nanotechnology has progressed rapidly in recent years and hence a large variety of 1D-, 2D-and 3D DNA nanostructures with various sizes, geometries and shapes is readily accessible. DNA-based nanoobjects are fabricated by straight forward design and self-assembly processes allowing the exact positioning of functional moieties and the integration of other materials. At the same time some of these nanosystems are characterized by a low toxicity profile. As a consequence, the use of these architectures in a biomedical context has been explored. In this review the progress and possibilities of pristine nucleic acid nanostructures and DNA hybrid materials for drug delivery will be discussed. For the latter class of structures, a distinction is made between carriers with an inorganic core composed of gold or silica and amphiphilic DNA block copolymers that exhibit a soft hydrophobic interior.

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“…12.18) [254]. Further research exploited this dehybridization/hybridization of complementary DNA strands, manipulated by the photoisomerization of azobenzene to control the access of guest molecules (rhodamine) to and from the pores of MSNs [255]. A similarly designed surface where the azobenzene SAM was derivatized with an RGD-containing peptide has enabled the reversible modulation of cell adhesion [256].…”

Section: Samsmentioning

confidence: 99%

Stimuli‐Responsive Surfaces in Biomedical Applications

Pranzetti¹,

Preece²,

Mendes³

2013

Intelligent Stimuli‐Responsive Materials

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Nature provides mechanisms that are able to dynamically control specific and nonspecific interactions between cells and biological surfaces [1,2]. Scientists have long tried to reproduce these dynamic biological events and have recently made an important step in that direction by creating artificial stimuli-responsive surfaces [3][4][5][6][7]. These smart substrates present modulatory surface properties that are able to respond to external chemical/biochemical [8][9][10][11][12], thermal [13][14][15], electrical [16][17][18][19][20], and optical stimuli [21][22][23][24][25][26][27][28][29][30][31]. Due to their dynamic nature such substrates are very appealing for applications in the biomedical field [32]. Progress to date has led to control over biomolecule activity [33] and immobilization of a diverse array of proteins, including enzymes [34] and antibodies [35]. These prior achievements have encouraged researchers to take the challenge of using dynamic surfaces to modulate larger and more complex systems, such as bacteria [36] and mammalian cells [37].Achieving control over surface properties could provide new insights in the understanding of cell behavior and can offer distinct benefits with regard to the development of medical devices. For instance, the modulation of cell attachment and detachment could lead to the prevention of unwanted bacteria fouling on implants, reducing the risk of infections and rejection [38][39][40][41][42]. Furthermore, dynamic surfaces able to present on demand regulatory signals to a cell could provide unprecedented opportunities in studies of cell responses in real-time. Cells in tissues adhere to and interact with their extracellular environment via specialized cell-cell and cell-extracellular

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Photon-Manipulated Drug Release from a Mesoporous Nanocontainer Controlled by Azobenzene-Modified Nucleic Acid

Cited by 228 publications

References 35 publications

Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates

Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates

Drug delivery systems based on nucleic acid nanostructures

Stimuli‐Responsive Surfaces in Biomedical Applications

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