Photolyse von adenin-l-N-oxid

Proteolytic activity, its inhibitors, and the blastic reaction in graft rejection

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In the control animals without grafts, both drugs caused 60-65% reduction of the physiologic enzymatic activity.Cramer (1965) has suggested that EACA acts by competing for lysine, and Taylor & Fudenberg (1 964) that it suppresses complement activity, which plays an important role in the transplantation reaction (Hager, Du Pay & Wallach, 1964;Cramer, 1965). On the basis of our observations on the enzymatic and blastic reactions, it must be concluded that the absence of any correlation of the degree of inhibition of proteolysis and the graft reaction arises from the manifold points of attack of EACA.

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