Photoinduzierte Mehrkomponentenreaktionen

Garbarino, Silvia; Ravelli, Davide; Protti, Stefano; Basso, Andrea

doi:10.1002/ange.201605288

Cited by 38 publications

(4 citation statements)

References 73 publications

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Section: Spatial Transcriptomicsunclassified

Emerging Roles of Spatial Transcriptomics in Liver Research

Fujiwara,

Kimura,

Nakagawa

2024

Semin Liver Dis

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The application of spatial transcriptomic technologies has significantly expanded our biological understanding. Hepatic intricate cellular heterogeneity and the pivotal role of zonation in maintaining hepatic function underscore how these technologies can unravel the complex spatial and cellular dynamics within both healthy and diseased livers. The article provides a comprehensive overview of the technical innovations and bioinformatics strategies that underpin spatial transcriptome analysis. Further, through recent discoveries in liver biology and pathology, enabled by these advanced methodologies, the review illustrates novel cell types, cell-cell interactions, and cellular reprograms in healthy and injured livers, as well as tumor microenvironment associated with patient prognosis and response to immune checkpoint inhibitors. With emphasizing the challenges and future directions, it points to the immense promise these technologies hold for identifying new therapeutic targets and advancing personalized medicine in hepatology, despite the hurdles in widespread adoption and standardization.

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“…11 35 74 83 84 97 100 113 115 119 123 127 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157…”

Section: Spatial Transcriptomicsunclassified

Emerging Roles of Spatial Transcriptomics in Liver Research

Fujiwara,

Kimura,

Nakagawa

2024

Semin Liver Dis

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“…. [22][23][24] Although the final product is directly achievable from the 1 a, 2 a and 3 a mixture, higher yields (41 %) and cleaner crudes were obtained when the GBB adduct 4 a was isolated in a prior step, possibly due to the sensitivity of isocyanides in the presence of particular oxidizing agents. Scheme 1.…”

Section: +mentioning

confidence: 99%

Extended Multicomponent Reactions with Indole Aldehydes: Access to Unprecedented Polyheterocyclic Scaffolds, Ligands of the Aryl Hydrocarbon Receptor

et al. 2020

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The participation of reactants undergoing a polarity inversion along a multicomponent reaction allows the continuation of the transformation with productive domino processes. Thus, indole aldehydes in Groebke–Blackburn–Bienaymé reactions lead to an initial adduct which spontaneously triggers a series of events leading to the discovery of novel reaction pathways together with direct access to a variety of linked, fused, and bridged polyheterocyclic scaffolds. Indole 3‐ and 4‐carbaldehydes with suitable isocyanides and aminoazines afford fused adducts through oxidative Pictet–Spengler processes, whereas indole 2‐carbaldehyde yields linked indolocarbazoles under mild conditions, and a bridged macrocycle at high temperature. These novel structures are potent activators of the human aryl hydrocarbon receptor signaling pathway.

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“…[11][12][13][14][15][16][17][18][19] The MCR technique has gained special attention and drawn considerable interest in modern synthetic chemistry and pharmaceutical chemistry owing to its advantages, such as high atom-economy, high selectivity, operational simplicity, structural diversity, short reaction time, low cost, low energy consumption, high yield, and easy purication process. [20][21][22][23][24] The imidazole scaffold belongs to an important heterocyclic compound due to their richness in various natural products and their widespread use in medicinal elds. 25,26 Imidazole ring system possesses a variety of pharmaceutical properties and plays a fundamental role in numerous biochemical processes.…”

Section: Introductionmentioning

confidence: 99%