Photoinduced destabilization of liposomes

Lamparski, Henry; Liman, Ulrich; Barry, Judith; Frankel, David A.; Ramaswami, Varadarajan; Brown, Michael F.; O’Brien, David F.

doi:10.1021/bi00118a008

Cited by 78 publications

(104 citation statements)

References 68 publications

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“…Investigations by Papahadjopoulos and coworkers (Dalke et al, 1990) photocleavage of lipid chains (Kusumi et al, 1989;Anderson & Thompson, 1992b), photoinduced change in the association of polyelectrolytes with liposomes (You & Tirrell, 1991), and the photopolymerization of lipids (Frankel et al, 1989;Lamparski et al, 1992). These methods were generally designed for liposome lysis.…”

Section: Endocytosismentioning

confidence: 99%

“…Uposomes not localized at the target cells and therefore not photolyzed would remain stable and would not deliver their toxic contents to any healthy cells. were prepared as described previously (Lamparski et al, 1992). All reactions were performed under yellow safe lights or in the dark to discourage photopolymerization of the sorbyl-containing compounds.…”

Section: Ie Research Goalmentioning

confidence: 99%

“…The synthesis of bis-SorbPC17,17 and a number of other bis-SorbPC lipids of various chain lengths has been reported (Lamparski et al, 1992;Lamparski et al, 1993;. Bis-SorbPC17,17 was chosen for the focus of this work since its behavior in mixed DOPE systems --before and after polymerization --has been characterized (Barry et al, 1992).…”

Section: Iiia Synthesis Of Bis-sorbpcmentioning

confidence: 99%

“…Bis-SorbPC17,17 was chosen for the focus of this work since its behavior in mixed DOPE systems --before and after polymerization --has been characterized (Barry et al, 1992). The degrees of polymerization of the mono-substituted analog of bis-SorbPC17,17, Le.…”

Section: Iiia Synthesis Of Bis-sorbpcmentioning

confidence: 99%

“…Synthesis of lipids that are asymmetric with respect to their sn-l and sn-2 constituent acyl chain composition, including mono-SorbPC16,17, can be accomplished by acylation of the sn-2 hydroxyl of any number of commercially available lysoPCs. The synthesis of mono-SorbPC16,17 was carried out by Dr. Henry Lamparski (Lamparski et al, 1992) and is not detailed here.…”

Section: Iiia Synthesis Of Bis-sorbpcmentioning

confidence: 99%

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Photoinduced Fusion of Liposomes

Bennett¹,

O’Brien²

1994

J. Am. Chem. Soc.

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This manuscript ,has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissenation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note wiD indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continning from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.

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Section: Endocytosismentioning

confidence: 99%

Section: Ie Research Goalmentioning

confidence: 99%

Section: Iiia Synthesis Of Bis-sorbpcmentioning

confidence: 99%

Section: Iiia Synthesis Of Bis-sorbpcmentioning

confidence: 99%

Section: Iiia Synthesis Of Bis-sorbpcmentioning

confidence: 99%

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Photoinduced Fusion of Liposomes

Bennett¹,

O’Brien²

1994

J. Am. Chem. Soc.

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Wavelength‐Selective Light‐Induced Release from Plasmon Resonant Liposomes

Leung

Kachur

Bobnick

et al. 2011

Adv Funct Materials

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Biodegradable, spectrally tunable plasmon resonant nanocapsules are created via the deposition of gold onto the surface of 100 nm diameter thermosensitive liposomes. These nanocapsules demonstrate selective release of encapsulated contents upon illumination with light of a wavelength matching their distinct resonance bands, which correspond to 760 and 1210 nm in this study. Spectrally selective release is accomplished through the use of multiple, low intensity laser pulses delivered over a period of less than four minutes, ensuring that illumination affects only the gold-coated liposomes and avoids heating the surrounding media. The result of this illumination scheme for selective release using multiple wavelengths of light is a biologically safe mechanism for realizing drug delivery, microfluidic, and sensor applications.

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Rapid Light‐Triggered Drug Release in Liposomes Containing Small Amounts of Unsaturated and Porphyrin–Phospholipids

Luo

Carter

et al. 2016

Small

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109

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Prompt membrane permeabilization is a requisite for liposomes designed for local stimuli-induced intravascular release of therapeutic payloads. Incorporation of a small amount (i.e. 5 molar percent) of an unsaturated phospholipid, such as dioleoylphosphatidylcholine (DOPC), accelerated near infrared (NIR) light-triggered release in porphyrin-phospholipid (PoP) liposomes by an order of magnitude. In physiological conditions in vitro, 90% of the loaded drug could be released in a minute with NIR irradiation, while liposomes maintained serum stability in the absence of NIR irradiation. This enabled rapid laser-induced drug release using remarkably low amounts of PoP (i.e. 0.3 molar percent). Light-triggered drug release occurred concomitantly with DOPC and cholesterol oxidation, as detected by mass spectrometry. In the presence of an oxygen scavenger or an antioxidant, light-triggered drug release was inhibited, suggesting the light triggered release mechanism was caused by singlet oxygen mediated oxidization of unsaturated lipids. Despite the irreversible modification of lipid composition, DOPC-containing PoP liposome permeabilization was transient. Human pancreatic xenograft growth in mice was significantly delayed with a single chemophototherapy treatment following intravenous administration of 6 mg/kg doxorubicin, loaded in liposomes containing small amounts of DOPC and PoP.

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Photoinduced destabilization of liposomes

Cited by 78 publications

References 68 publications

Photoinduced Fusion of Liposomes

Photoinduced Fusion of Liposomes

Wavelength‐Selective Light‐Induced Release from Plasmon Resonant Liposomes

Rapid Light‐Triggered Drug Release in Liposomes Containing Small Amounts of Unsaturated and Porphyrin–Phospholipids

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