Photoinactivation of Virus Infectivity by Hypocrellin A

Hirayama, Junichi; Ikebuchi, Kenji; Abe, Hideki; Kwon, Kil‐Won; Ohnishi, Yutaka; Horiuchi, Motohiro; Shinagawa, Morikazu; Ikuta, Kazuyoshi; Kamo, Naoki; Sekiguchi, Sadayoshi

doi:10.1111/j.1751-1097.1997.tb03209.x

Cited by 71 publications

(34 citation statements)

References 21 publications

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“…Nevertheless, we noted that the rigid and planar hydrophobic moiety present in all effective RAFIs is a perylene group (Fig. 1A) (3,6), which is a well-known fluorescent lipid probe and photosensitizer (16)(17)(18).…”

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confidence: 99%

The Rigid Amphipathic Fusion Inhibitor dUY11 Acts through Photosensitization of Viruses

Vigant

Hollmann

Lee

et al. 2014

J Virol

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cRigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen ( 1 O 2 ), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.

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mentioning

confidence: 99%

The Rigid Amphipathic Fusion Inhibitor dUY11 Acts through Photosensitization of Viruses

Vigant

Hollmann

Lee

et al. 2014

J Virol

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“…It has also been reported that HA has a strong photodynamic therapy(PDT) of tumors effect and impressive antiviral activity against human immunodeficiancy virus type I (HIV-l), vesicular stomatitis virus (VSV) [3,4]. However, the mechanism underlying the therapeutic effect is not clearly known.…”

Section: Introductionmentioning

confidence: 97%

<title>Initiation of apoptosis by photosensitization with hypocrellin A and the repression of Vitamin E</title>

Cao¹,

Zhang²,

Li³

1998

Biomedical Optics and Lasers: Diagnostics and Treatment

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PDT-induced HeLa cells apoptosis was evidenced by morphological changes, DNA fragmentation and decrease of mitochondria dehydrogenase activity. Apoptosis was associated with the formation of 1P3 of photosensitized cells and rapid release of Ca2 from intracellular pools. Vitamin E , which was added before irradiation, could significantly protect cells against cell death, indicating that reactive oxygen species (ROS) play an important role in apoptotic cell death.

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“…Though presenting high photodynamic killing activity toward many kinds of tumor cell lines [3,4], viruses [5][6][7][8], and bacteria [9], the clinical use of the natural hypocrellins is severely limited by their poor water solubility and low absorptivity in the phototherapeutic window (600-900 nm), which urged the evolvement of various hypocrellin derivatives, such as sulfonated HA [10], glycosylated HB [11], cyclodextrin-modified HB [12], quaternary ammonium group-substituted HB [13], and tyrosine-appended HB [14,15]. In this respect, the metal complexes of hypocrellins are very attractive because they can be prepared easily and the enhanced water solubility and improved absorptivity within the phototherapeutic window can be achieved simultaneously [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%