A new Co(III)–hypocrellin B complex with enhanced photonuclease activity

Sun, Yi; Hou, Yuanjun; Zhou, Qianxiong; Chen, Jingrong; Zhang, Baowen; Wang, Xuesong

doi:10.1016/j.jinorgbio.2011.03.021

Cited by 18 publications

(4 citation statements)

References 49 publications

(56 reference statements)

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“…To examine the photodynamic mechanisms behind the DNA photocleavage, a series of ROS scavengers, including NaN 3 for 1 O 2 , [28] SOD and catalase for superoxide anion radical (O 2 À· ), [29] and KI for COH, [30] were utilized to modulate the photocleavage activities of 6 and 7. As shown in Figure 9, only NaN 3 inhibits the photocleavage activity of 7 markedly, and this indicates a 1 O 2 mechanism or Type II mechanism for 7.…”

Section: Dna Photocleavagementioning

confidence: 99%

DNA Photocleavage by a Cationic BODIPY Dye through Both Singlet Oxygen and Hydroxyl Radical: New Insight into the Photodynamic Mechanism of BODIPYs

et al. 2012

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Two new NIR-absorbing BODIPY dyes, each bearing two pyridinium groups, are synthesized and their DNA-binding affinities and DNA photocleavage abilities examined in depth. While one BODIPY dye photocleaves DNA mainly through singlet oxygen, the other photocleaves DNA through both singlet oxygen and hydroxyl radical. To the best of our knowledge, this is the first example of a hydroxyl radical being involved in the photodynamic behavior of BODIPY-type dyes. EPR experiments confirm the ability of these and several related BODIPYs to generate superoxide anion radical and hydroxyl radical. This finding may shed light on the mechanism of BODIPY-based photodynamic therapy (PDT) and open a new avenue for development of more efficient BODIPY-type PDT agents.

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Section: Dna Photocleavagementioning

confidence: 99%

DNA Photocleavage by a Cationic BODIPY Dye through Both Singlet Oxygen and Hydroxyl Radical: New Insight into the Photodynamic Mechanism of BODIPYs

et al. 2012

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“…Photodynamic therapy (PDT) is a minimally invasive cancer treatment compared to surgery, chemotherapy, and radiotherapy [ 173 ]. Double-stranded DNA (dsDNA) is one of the potential targets of PDT [ 174 ]. During PDT, photosensitizer molecules accumulate in diseased tissues.…”

Section: Potential Involvement Of G4 In Ros-related Diseasesmentioning

confidence: 99%

Crosstalk between G-quadruplex and ROS

Jiang

et al. 2023

Cell Death Dis

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The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid base damage, DNA strand breakage, inter- and intra-strand cross-linking of nucleic acids, and protein-DNA cross-linking involved in the pathogenesis of cancer, neurodegenerative diseases, and aging. G-quadruplex (G4) is a stacked nucleic acid structure that is ubiquitous across regulatory regions of multiple genes. Abnormal formation and destruction of G4s due to multiple factors, including cations, helicases, transcription factors (TFs), G4-binding proteins, and epigenetic modifications, affect gene replication, transcription, translation, and epigenetic regulation. Due to the lower redox potential of G-rich sequences and unique structural characteristics, G4s are highly susceptible to oxidative damage. Additionally, the formation, stability, and biological regulatory role of G4s are affected by ROS. G4s are involved in regulating gene transcription, translation, and telomere length maintenance, and are therefore key players in age-related degeneration. Furthermore, G4s also mediate the antioxidant process by forming stress granules and activating Nrf2, which is suggestive of their involvement in developing ROS-related diseases. In this review, we have summarized the crosstalk between ROS and G4s, and the possible regulatory mechanisms through which G4s play roles in aging and age-related diseases.

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“…37 It was reported that some Cu(II), Co(III) and Oxovanadium(IV) HB complexes with certain molecular weight could result in e®ec-tive photodamage to DNA than free HB. [40][41][42] An in vivo study indicated the hypocrellins complexes with aluminium ions might be dissociated in vivo, then lead to aggregation of free hypocrellins and vascular embolization (unpublished result), which may be a common problem for this kind of complexes.…”

Section: Hypocrellin-metal Ion Complexesmentioning

confidence: 99%

Drug-delivery and multifunction possibilities of hypocrellin photosensitizers

Deng

Xie

Zhao

2015

J. Innov. Opt. Health Sci.

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Photodynamic therapy (PDT) has been a routine treatment of tumors and some microvascular diseases, but clinically available photosensitizers are still scarce. Among all kinds of photosensitizers, hypocrellins possess the most characteristics of ideal photosensitizers, such as, high photo-activity but low dark toxicity, fast clearance from tissues. This review is focused on two main topics, drug-delivery problem of hypocrellins and how the environment-sensitive°uorescence of hypocrellins was used for recognition of various biomolecules. Drug-delivery of hypocrellins was mainly achieved in two strategies -preparing the drug-delivery vehicles and¯nding quantitatively amphiphilic derivatives. Hypocrellin°uorescence originated from the intramolecular proton transfer is very distinct from other kinds of photosensitizers. Recently, it was proved that quantitative hypocrellin°uorescence could not only recognize various biomolecules, including proteins, polysaccharides and lipids, but also distinguish the speci¯c binding from nonspeci¯c binding with some kind of biomolecules. Meantime, hypocrellin°uorescence was pH-sensitive. It is known that tumor cells or tissues have the features of a large amount of lipid, neonatal collagen, over-expression of polysaccharides, and lower pH values compared to normal tissues. According to the relative but not absolute speci¯city, further studies on quantitative recognition of various biomolecules at a cellular level, may¯nd a new clue to treat tumors by joint usage of photodynamic diagnosis (PDD) and PDT.

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A new Co(III)–hypocrellin B complex with enhanced photonuclease activity

Cited by 18 publications

References 49 publications

DNA Photocleavage by a Cationic BODIPY Dye through Both Singlet Oxygen and Hydroxyl Radical: New Insight into the Photodynamic Mechanism of BODIPYs

DNA Photocleavage by a Cationic BODIPY Dye through Both Singlet Oxygen and Hydroxyl Radical: New Insight into the Photodynamic Mechanism of BODIPYs

Crosstalk between G-quadruplex and ROS

Drug-delivery and multifunction possibilities of hypocrellin photosensitizers

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