Photoelectrochemical detection of human epidermal growth factor receptor 2 (HER2) based on Co3O4-ascorbic acid oxidase as multiple signal amplifier

Luo, Junjun; Liang, Dong; Li, Xiaoqing; Liu, Shuping; Deng, Lei; Ma, Fanghui; Wang, Zaoxia; Yang, Minghui; Chen, Xiang

doi:10.1007/s00604-021-04829-7

Cited by 19 publications

(7 citation statements)

References 40 publications

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“…Among the biogenic approaches, the use of different parts of green plants extracted as a capping and reducing agent to control the overgrowth of metal oxide nanoparticles is the most favorable synthesis method as compared to the counter parts. Among the different types of metal oxide NPs, cobalt oxide (Co 3 O 4 ) NPs received greater significance due to their high redox chemistry, high electrocatalytic activity, fast electron transfer kinetics, efficient stability, and low cost [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…As the plant is very rich in bioactive molecules that have body building and health keeping function, it is highly cultivated and the increased demand for processed potato products generates large amounts of byproducts from a variety of sources such as peel, leaves, and stems [ 22 ]. Solanum tuberosum leaf is a useful source of diverse bioactive compounds and well known by its high level of starch, crude fiber, vitamins, amino acids, minerals, acid-soluble and acid insoluble lignin, and lipids [ 20 , 21 ]. Due this fact, the plant parts, specifically the leaf could be accessed with zero cost since they exist as byproduct and are employed for the biogenic synthesis of various types of NPs, instead of using toxic and too costly capping and reducing agent conductive polymers and chemicals.…”

Section: Introductionmentioning

confidence: 99%

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[Retracted] Solanum tuberosum Leaf Extract Templated Synthesis of Co3O4 Nanoparticles for Electrochemical Sensor and Antibacterial Applications

Bekele

Murthy

Muniswamy³

et al. 2022

Bioinorganic Chemistry and Applications

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Green synthesis of metal oxide nanoparticles (NPs) is a viable alternative methodology because of cost-effective and availability of environmentally friendly templates for desired application, which has attracted the attention of researchers in recent years. In the present study, Co3O4 NPs were synthesized in various volume ratios in the presence of Solanum tuberosum leaf extract as a template. The synthesized Co3O4 NPs were characterized by X-ray diffraction (XRD), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX), transmission electron microscopy (TEM), high resolution transmission electron microscopy (HRTEM), surface area electron diffraction (SAED), UV-Vis diffuse reflectance spectroscopy (UV-DRS), and Fourier transform infrared (FTIR) spectroscopy. XRD analysis found that the average crystalline sizes for the 1 : 2, 1 : 1, and 2 : 1 volume ratios was 25.83, 21.05, and 27.98 nm, respectively. SEM-EDX and TEM analyses suggest that the green-synthesized Co3O4 NPs are spherical in shape without the presence of impurities. The band gap E g values of the 1 : 2, 1 : 1, and 2 : 1 volume ratios of Co3O4 NPs were found to be 1.83, 1.77, and 2.19 eV, respectively. FTIR analysis confirmed the presence of various bioactive ingredients within the leaf extract of Solanum tuberosum. Co3O4 NPs-modified electrodes showed better sensing capability towards ascorbic acid and citric acid due to enhanced electron transfer kinetics. Among three volume ratios (1 : 2, 1 : 1, and 2 : 1) of Co3O4 nanoelectrodes, 1 : 1 and 2 : 1 were identified as the best performing nanoelectrodes. This is possibly due to the high catalytic behavior and the more homogenized surface structure. Co3O4 (1 : 2) nanodrug showed the enhanced antibacterial activity (16 mm) towards S. aureus which is attributed to the formation of enhanced reactive oxygen species (ROS).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

[Retracted] Solanum tuberosum Leaf Extract Templated Synthesis of Co3O4 Nanoparticles for Electrochemical Sensor and Antibacterial Applications

Bekele

Murthy

Muniswamy³

et al. 2022

Bioinorganic Chemistry and Applications

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“…The selectivity and specificity of the sensor were detected using human IgG, CEA, BACE1, p53 and human IgM, which confirmed its good selectivity and specificity. The linear range was 1 pg/mL~1 ng/mL, and the detection limit was 0.026 pg/mL [ 90 ].…”

Section: Application Of Biosensor In Detection Of Tumor Biomarkersmentioning

confidence: 99%

Recent Progress in Biosensors for Detection of Tumor Biomarkers

Jiang

Xue

et al. 2022

Molecules

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Cancer is a leading cause of death worldwide, with an increasing mortality rate over the past years. The early detection of cancer contributes to early diagnosis and subsequent treatment. How to detect early cancer has become one of the hot research directions of cancer. Tumor biomarkers, biochemical parameters for reflecting cancer occurrence and progression have caused much attention in cancer early detection. Due to high sensitivity, convenience and low cost, biosensors have been largely developed to detect tumor biomarkers. This review describes the application of various biosensors in detecting tumor markers. Firstly, several typical tumor makers, such as neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), squamous cell carcinoma antigen (SCCA), carbohydrate, antigen19-9 (CA19-9) and tumor suppressor p53 (TP53), which may be helpful for early cancer detection in the clinic, are briefly described. Then, various biosensors, mainly focusing on electrochemical biosensors, optical biosensors, photoelectrochemical biosensors, piezoelectric biosensors and aptamer sensors, are discussed. Specifically, the operation principles of biosensors, nanomaterials used in biosensors and the application of biosensors in tumor marker detection have been comprehensively reviewed and provided. Lastly, the challenges and prospects for developing effective biosensors for early cancer diagnosis are discussed.

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“…It is related to various cancers, such as breast, ovarian, gastric, esophageal, salivary gland, lung, and so on. , Therefore, its assay is crucial for early diagnosis and therapy, and the development of detection techniques attracts much attention. Up to now, several methods, including fluorescence, electrochemistry (EC), , electrochemiluminescence, photoelectrochemistry (PEC), , and chromatography, have been reported for HER2 monitoring. However, single-mode detection easily suffers from external interference, producing false positive/negative results.…”

Section: Introductionmentioning

confidence: 99%

BiOBr_0.8I_0.2/CoS_x Nanostructure-Based Photoelectrochemical and Electrochemical Dual-Mode Sensing Platform for the Ultrasensitive and Highly Selective Detection of HER2

Wang

Shi

et al. 2022

ACS Appl. Nano Mater.

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Sensitive and accurate detection of tumor markers is significant for early diagnosis and cancer treatment, but it remains challenging. A promising solution is to integrate different detection strategies into the same sensing platform. Herein, a BiOBr 0.8 I 0.2 /CoS x nanocomposite with high photoelectrochemical (PEC) and electrochemical (EC) activity is prepared by a hydrothermal method and afterward in situ visible light irradiation. The light irradiation makes BiOBr 0.8 I 0.2 /CoS turn into BiOBr 0.8 I 0.2 /CoS x (x = 1−2), and the photocurrent thus increases by 5 times. Compared with the BiOBr 0.8 I 0.2 , the photocurrent of the composite increased by 74 times due to the formation of a heterojunction and the enhanced sensitization of CoS x . Furthermore, the nanocomposite can exhibit a high cathodic signal. Therefore, it is used to construct a PEC and EC dual-mode sensing platform for the detection of human epidermal growth factor receptor-2 (HER2), by combining with the aptamer of HER2. Due to the steric hindrance of HER2, the PEC and EC signals change with HER2 concentration. Under the optimized conditions, the sensing platform shows quite low detection limits (0.31 and 1.06 pg/mL) and large linear ranges (0.001−10 and 0.005−15 ng/mL, for PEC and EC mode, respectively). It also demonstrates high selectivity, excellent stability, and good applicability. The sensing platform can also be applied to detect other markers by replacing the recognition element.

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Photoelectrochemical detection of human epidermal growth factor receptor 2 (HER2) based on Co3O4-ascorbic acid oxidase as multiple signal amplifier

Cited by 19 publications

References 40 publications

[Retracted] Solanum tuberosum Leaf Extract Templated Synthesis of Co3O4 Nanoparticles for Electrochemical Sensor and Antibacterial Applications

[Retracted] Solanum tuberosum Leaf Extract Templated Synthesis of Co3O4 Nanoparticles for Electrochemical Sensor and Antibacterial Applications

Recent Progress in Biosensors for Detection of Tumor Biomarkers

BiOBr_0.8I_0.2/CoS_x Nanostructure-Based Photoelectrochemical and Electrochemical Dual-Mode Sensing Platform for the Ultrasensitive and Highly Selective Detection of HER2

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Photoelectrochemical detection of human epidermal growth factor receptor 2 (HER2) based on Co3O4-ascorbic acid oxidase as multiple signal amplifier

Cited by 19 publications

References 40 publications

[Retracted] Solanum tuberosum Leaf Extract Templated Synthesis of Co3O4 Nanoparticles for Electrochemical Sensor and Antibacterial Applications

[Retracted] Solanum tuberosum Leaf Extract Templated Synthesis of Co3O4 Nanoparticles for Electrochemical Sensor and Antibacterial Applications

Recent Progress in Biosensors for Detection of Tumor Biomarkers

BiOBr0.8I0.2/CoSx Nanostructure-Based Photoelectrochemical and Electrochemical Dual-Mode Sensing Platform for the Ultrasensitive and Highly Selective Detection of HER2

Contact Info

Product

Resources

About

BiOBr_0.8I_0.2/CoS_x Nanostructure-Based Photoelectrochemical and Electrochemical Dual-Mode Sensing Platform for the Ultrasensitive and Highly Selective Detection of HER2