Photodynamic therapy with green light for the treatment of vulvar lichen sclerosus – Preliminary results

Osiecka, Beata J.; Jurczyszyn, Kamil; Nockowski, Piotr; Murawski, Marek; Ziółkowski, Piotr

doi:10.1016/j.pdpdt.2016.11.015

Cited by 23 publications

(29 citation statements)

References 17 publications

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“…A wavelength of approximately 540 nm penetrates mainly the epidermis, so, in theory, it may be less painful while maintaining full photodynamic effect on the cells. Our previous studies confirm the efficacy and excellent tolerance of green light in the treatment of lichen sclerosus (15). This directed our attention to the possibility of using green light PDT in the treatment of AKs.…”

Section: Discussionsupporting

confidence: 71%

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Treatment of Actinic Keratosis with Photodynamic Therapy Using Red or Green Light: A Comparative Study

Osiecka¹,

Nockowski²,

Szepietowski³

2018

Acta Derm Venerol

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Actinic keratosis (AK) is the most common in situ cancerous skin lesion. Compared with other approved treatment modalities photodynamic therapy is preferred by patients due to faster recovery and improved cosmetic outcome. However, pain during irradiation is an important drawback. The aim of this study was to compare the effectiveness and tolerability of topical aminolaevulinic acid-photodynamic therapy in the treatment of AK on the head using red and green light. Complete remissions after 3 sessions of photodynamic therapy at 2-week intervals following 9 months of observation were 91.67% for red light and 86.67% for green light (difference not significant). The mean pain value was significantly greater in areas irradiated with red light compared with green light for all 3 sessions. This comparative study demonstrates that aminolaevulinic acid-photodynamic therapy with green light is of similar efficacy as that with red light in the treatment of middle/moderate AK, but causes less pain.

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Section: Discussionsupporting

confidence: 71%

“…The fluence rate for both types of light was 86 mW/cm 2 . The irradiation was performed in a dark room in a fractionated mode during each session: 3 min of irradiation and 1-min pause (15). No analgesics were given.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Treatment of Actinic Keratosis with Photodynamic Therapy Using Red or Green Light: A Comparative Study

Osiecka¹,

Nockowski²,

Szepietowski³

2018

Acta Derm Venerol

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“…Considering that procedure-related pain is an important adverse effect which limits the patients' adherence to treatment (111), some authors aimed their research at finding alternatives in order to decrease pain and avoid treatment discontinuation (112,113). Cabete et al reported good pain control after using inhaled nitrous oxide/oxygen gas mixture during MAL-PDT for vulvar LS.…”

Section: Updates In Pdt For Lichen Sclerosus -A Dermatosis With Potenmentioning

confidence: 99%

Photodynamic therapy: A hot topic in dermato-oncology (Review)

et al. 2019

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Photodynamic therapy (PDT) is a modern, non-invasive therapeutic method used for the destruction of various cells and tissues. It requires the simultaneous presence of three components: a photosensitizer (PS), a light source and oxygen. Precancerous skin lesions are conditions associated with a high likelihood of malignant transformation to squamous cell carcinoma. Data available so far indicate that PDT is a promising treatment method which can be successfully employed in several medical fields including dermatology, urology, ophthalmology, pneumology, cardiology, dentistry and immunology. Numerous authors therefore have studied this technique in order to improve its efficacy. As a result, significant advancement has been achieved with regard to PSs and drug delivery systems. Substantial progress was also obtained with respect to PDT for the treatment of precancerous skin lesions, several authors focusing their efforts on the study of daylight-PDT and on identifying methods of decreasing technique-related pain. This review reports on the most recent findings in PDT, with emphasis on cutaneous precancerous lesions. Contents 1. Introduction 2. Photodynamic therapy-generalities 3. Updates in PDT components 4. Updates in PDT for the management of actinic keratoses 5. Updates in PDT for Bowen's disease and erythroplasia of Queyrat 6. Updates in PDT in the treatment of other precancerous skin lesions: Actinic cheilitis and keratoacanthoma 7. Updates in PDT for lichen sclerosus-a dermatosis with potential for malignant transformation 8. Discussion

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“…6 Several light sources have been used in PDT, but red light with a 630-nm absorption peak is the most commonly used, due to its deep penetration in tissues, particularly important in the treatment of precancerous skin lesions and skin cancer. 6,7 Daylight PDT is a variant of PDT which has been increasingly used in the past few years. 2,8 This type of PDT uses the same prodrugs, but the light sources to induce the photodynamic reaction are different; instead of using a red-light source, such as in conventional PDT, daylight PDT uses natural sunlight.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy in dermatology: Beyond current indications

Queirós

Garrido

Silva

et al. 2020

Dermatologic Therapy

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Photodynamic therapy (PDT) has long been used in dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ, and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years, PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious dermatoses. These results, probably explained by its immunomodulatory, anti-inflammatory, and bactericidal effects, may lead to an expansion of PDT indications in the upcoming years. In this article, conditions where PDT may be useful are reviewed, thus highlighting the potential of this therapeutic modality for the dermatologist.

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Photodynamic therapy with green light for the treatment of vulvar lichen sclerosus – Preliminary results

Cited by 23 publications

References 17 publications

Treatment of Actinic Keratosis with Photodynamic Therapy Using Red or Green Light: A Comparative Study

Treatment of Actinic Keratosis with Photodynamic Therapy Using Red or Green Light: A Comparative Study

Photodynamic therapy: A hot topic in dermato-oncology (Review)

Photodynamic therapy in dermatology: Beyond current indications

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