Photodynamic therapy of lung cancer, where are we?

Crous, Anine; Abrahamse, Heidi

doi:10.3389/fphar.2022.932098

Cited by 24 publications

(16 citation statements)

References 91 publications

(112 reference statements)

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“…[ 104,105 ] This class of therapies is approved by the FDA for cancers such as basal cell skin cancer and non‐small cell lung cancer. [ 106,107 ]…”

Section: Mnas Are Being Explored To Treat Infectious Cancerous Allerg...mentioning

confidence: 99%

“…[104,105] This class of therapies is approved by the FDA for cancers such as basal cell skin cancer and non-small cell lung cancer. [106,107] MNAs could provide an alternative to this traditional form of delivery because they target the release of TAAs and adjuvants to APCs in the skin. Two currently approved methods of delivery are systemic (I.V.…”

Section: Photodynamic and Photothermal Therapiesmentioning

confidence: 99%

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Exploiting Unique Features of Microneedles to Modulate Immunity

et al. 2023

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Microneedle arrays (MNAs) are small patches containing hundreds of short projections that deliver signals directly to dermal layers without causing pain. These technologies are of special interest for immunotherapy and vaccine delivery because they directly target immune cells concentrated in the skin. The targeting abilities of MNAs result in efficient immune responses—often more protective or therapeutic—compared to conventional needle delivery. MNAs also offer logistical benefits, such as self‐administration and transportation without refrigeration. Thus, numerous preclinical and clinical studies are exploring these technologies. Here we discuss the unique advantages of MNA, as well as critical challenges – such as manufacturing and sterility issues – the field faces to enable widespread deployment. We explain how MNA design parameters can be exploited for controlled release of vaccines and immunotherapies, and the application to preclinical models of infection, cancer, autoimmunity, and allergies. We also discuss specific strategies to reduce off‐target effects compared to conventional vaccine delivery routes, and novel chemical and manufacturing controls that enable cargo stability in MNAs across flexible intervals and temperatures. We then examine clinical research using MNAs. We conclude with drawbacks of MNAs and the implications, and emerging opportunities to exploit MNAs for immune engineering and clinical use.This article is protected by copyright. All rights reserved

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“…[ 104,105 ] This class of therapies is approved by the FDA for cancers such as basal cell skin cancer and non‐small cell lung cancer. [ 106,107 ]…”

Section: Mnas Are Being Explored To Treat Infectious Cancerous Allerg...mentioning

confidence: 99%

Section: Photodynamic and Photothermal Therapiesmentioning

confidence: 99%

Exploiting Unique Features of Microneedles to Modulate Immunity

et al. 2023

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“…As you can see in Figure 5, there are three elements involved in PDT: a photosensitizer, oxygen, and light. [126,127] Photosensitizers are compounds that are activated when they absorb specific wavelengths of light. Irradiation of malignant tissues generates free radicals (ROS) and other oxidation products with significant cytotoxic potential, resulting in the death of cancer cells.…”

Section: Hydrophilic and Hydrophobicmentioning

confidence: 99%

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Shahrivar,

Fakhr,

Abbasgholinejad

et al. 2023

Advanced Therapeutics

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Lung cancer remains the leading cause of cancer‐related deaths worldwide, and conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are emerging as a promising strategy for the treatment of lung cancer, owing to their ability to selectively deliver therapeutic agents to cancer cells while minimizing off‐target effects. Smart NPs can respond to specific stimuli such as changes in pH, temperature, or enzymes, allowing them to release their cargo only when triggered. Among the various types of smart NPs, lipid‐based NPs, including liposomes, solid lipid nanoparticles, cubosomes, and extracellular vesicles, have garnered the highest interest due to their biocompatibility, low toxicity, and versatility in encapsulating a wide variety of drugs and genetic material. This review discusses the current status of smart lipid‐based NPs in lung cancer treatment, including recent advances in targeting strategies, stimuli‐responsive NPs, and combination therapies. The challenges and opportunities associated with translating smart lipid‐based NPs for lung cancer treatment into clinical applications are also discussed. This review highlights the potential of smart lipid‐based NPs to revolutionize lung cancer treatment and improve patient outcomes.

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“…A particular advantage of PDT is its high selectivity and the absence of side effects, unlike in chemotherapy, radiotherapy, and surgery. Properly selected photosensitizing compounds, characterized by the specific absorption of radiation in the visible range and ability to fluorescence, as well as exposure conditions (presence of oxygen, dose), play a crucial role here [ 14 ]. A novelty in the PDT method is its combination with nanotechnology and nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Composites Containing Boron-Dipyrromethene Derivatives for Biomedical Applications

Smolarkiewicz-Wyczachowski

Kaczmarek

Piskorz

et al. 2023

IJMS

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The work is devoted to preparing and characterizing the properties of photosensitive composites, based on chitosan proposed for photodynamic therapy. Chitosan films with a 5% addition of two BODIPY dyes were prepared by solution casting. These dyes are dipyrromethene boron derivatives with N-alkyl phthalimide substituent, differing in the presence of iodine atoms in positions 2 and 6 of the BODIPY core. The spectral properties of the obtained materials have been studied by infrared and UV-vis absorption spectroscopy and fluorescence, both in solutions and in a solid state. Surface properties were investigated using the contact angle measurement. The morphology of the sample has been characterized by Scanning Electron and Atomic Force Microscopy. Particular attention was paid to studying the protein absorption and kinetics of the dye release from the chitosan. Adding BODIPY to the chitosan matrix leads to a slight increase in hydrophilicity, higher structure heterogeneity, and roughness, than pure chitosan. The presence of iodine atoms in the BODIPY structure caused the bathochromic effect, but the emission quantum yield decreased in the composites. It has been found that BODIPY-doped chitosan interacts better with human serum albumin and acidic α-glycoprotein than unmodified chitosan. The release rate of dyes from films immersed in methanol depends on the iodine present in the structure.

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Photodynamic therapy of lung cancer, where are we?

Cited by 24 publications

References 91 publications

Exploiting Unique Features of Microneedles to Modulate Immunity

Exploiting Unique Features of Microneedles to Modulate Immunity

Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions

Chitosan Composites Containing Boron-Dipyrromethene Derivatives for Biomedical Applications

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