Photodynamic Therapy of Choroidal Haemangioma Associated with Sturge–Weber Syndrome

Clinical use of photodynamic therapy in ocular tumors

“…The most frequent treatment modality for diffuse choroidal hemangioma is external beam radiotherapy, with photons in 31 cases 73,74,81,113,138,148,162 and with protons in 21 cases. 47,81,221 The third most common method reported in the literature is PDT, which was used in 10 cases, where 7 cases were followed up after at least 6 months, 11,39,88,126,179,203 and 3 cases in 3 studies were followed up in less than 6 months. 9,18,203 In all cases treated with PDT, standard protocol with verteporfin was used, and the results are promising.Visual acuity increased, exudation resolved, and tumor size regressed.…”

Photodynamic Therapy for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome

“…Patients with diffuse choroidal hemangiomas are most likely to develop secondary retinal detachment with shifting of the subretinal fluid [5, 6]. Diffuse choroidal hemangioma can lead to visual loss due to refractive errors, foveal distortion, and exudative retinal detachment [7]. Diffuse choroidal hemangiomas have been treated with radiotherapy, proton beam, stereotactic radiotherapy, plaque radiation therapy, and photodynamic therapy (PDT) [5].…”

“…Diffuse choroidal hemangiomas have been treated with radiotherapy, proton beam, stereotactic radiotherapy, plaque radiation therapy, and photodynamic therapy (PDT) [5]. PDT is currently being advocated for circumscribed choroidal hemangioma with good short-term results [7]. To date, there have been only seven case reports of successful PDT treatment for diffuse choroidal hemangiomas [4, 5].…”

Diffuse choroidal haemangioma in Sturge–Weber syndrome treated with photodynamic therapy under general anaesthesia

“…Vision-threatening complications are exudative retinal detachment and amblyopia. Three recently published reports indicate that PDT with verteporfin can be used as a therapeutic option for exudative retinal detachment associated with diffuse choroidal haemangioma [1,3,10]. Results show an effective resolution of subretinal fluid, and in these case studies no side effects apart from residual pigment epithelium mottling were reported.…”

“…Photodynamic therapy (PDT) has recently been described as a therapeutic option for exudative retinal detachment associated with diffuse choroidal haemangioma in SturgeWeber syndrome [1,3,10]. Our case illustrates that disappearance of an exudative retinal detachment after PDT can take several months and it shows that PDT with verteporfin can be applied under general anaesthesia.…”