Photodynamic therapy-induced pain: a patient centred survey

Kapur, N.; Lang, Kristin; Braathen, Lasse R.

doi:10.1016/j.jaad.2003.10.471

Cited by 8 publications

(7 citation statements)

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“…The usefulness of photodynamic therapy may be limited by pain and the need for pain medication. 16 In terms of convenience, photodynamic therapy is relatively inconvenient (involving a two-stage treatment process spaced several hours apart with more than one treatment session generally required) in contrast to imiquimod therapy, which requires multiple single-use sachets andFsimplest of allF5-FU therapy which requires just a single tube. In addition, as 5-FU and imiquimod are home-based rather than office-based therapies they are particularly well suited to patients who have practical difficulties traveling to a doctor's office (including, for example, elderly patients or those living in a nursing home).…”

Section: Discussionmentioning

confidence: 99%

5% 5-Fluorouracil Cream for the Treatment of Small Superficial Basal Cell Carcinoma: Efficacy, Tolerability, Cosmetic Outcome, and Patient Satisfaction

Gross

Kircik²,

Kricorian

2007

Dermatol Surg

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Section: Discussionmentioning

confidence: 99%

5% 5-Fluorouracil Cream for the Treatment of Small Superficial Basal Cell Carcinoma: Efficacy, Tolerability, Cosmetic Outcome, and Patient Satisfaction

Gross

Kircik²,

Kricorian

2007

Dermatol Surg

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“… Good information Oral treatment for PDT‐pain has an uncertain effect. Paracetamol (1 g) 1 h before light exposure can be attempted 42 Subcutaneous infiltration anaesthesia without adrenalin a …”

Section: Adverse Effectsmentioning

confidence: 99%

“…Oral treatment for PDT‐pain has an uncertain effect. Paracetamol (1 g) 1 h before light exposure can be attempted 42 …”

Section: Adverse Effectsmentioning

confidence: 99%

Guidelines for practical use of MAL‐PDT in non‐melanoma skin cancer

Christensen

Warloe

Kroon

et al. 2010

Acad Dermatol Venereol

105

108

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Methyl aminolaevulinate photodynamic therapy is increasingly practiced in the treatment of actinic keratoses, Bowen's disease and basal cell carcinomas. This method is particularly suitable for treating multiple lesions, field cancerization and lesions in areas where a good cosmetic outcome is of importance. Good treatment routines will contribute to a favourable result. The Norwegian photodynamic therapy (PDT) group consists of medical specialists with long and extensive PDT experience. With support in the literature, this group presents guidelines for the practical use of topical PDT in non-melanoma skin cancer.

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“…This is likely to be in part because our understanding of the mechanisms of PDT-induced pain and which mediators are relevant is unclear. In one review of 160 patients treated with Metvix PDT over a 6-month period, patients received either paracetamol or Tramadol before PDT, and pain scores did not differ significantly between the two groups, although this was not a prospective study design and therefore caution is required in interpreting these data (81). In a separate report, pre-medication with oral codeine phosphate and paracetamol, combined with intra-oral injection of mepivacaine was used during PDT for actinic cheilitis.…”

Section: Pain Managementmentioning

confidence: 99%

Adverse effects of topical photodynamic therapy

Ibbotson¹

2011

Photoderm Photoimm Photomed

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SummaryBackground/purpose: Topical photodynamic therapy (PDT) is increasingly used in dermatology, particularly for the treatment of superficial non-melanoma skin cancer and dysplasia. Treatment is generally considered to be well tolerated, although pain during PDT can be a limiting factor. This review explores the adverse effects of topical PDT. Methods: A thorough search of the literature using Medline was undertaken and published data were evaluated and presented in conjunction with our own experience. Results: Pain during PDT is the most commonly reported adverse effect and may prevent successful treatment delivery, although low-irradiance regimes and use of nerve blocks or cooling air can be used to reduce pain. Other acute and chronic adverse effects are reported but do not seem to be limiting factors in the use of topical PDT. To date, there is no convincing evidence for a carcinogenic effect of this treatment. Conclusion: Topical PDT is associated with few significant adverse effects, although methods to optimize regimes and minimize pain are required to improve the acceptability of this therapy for patients.

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Photodynamic therapy-induced pain: a patient centred survey

Cited by 8 publications

References 0 publications

5% 5-Fluorouracil Cream for the Treatment of Small Superficial Basal Cell Carcinoma: Efficacy, Tolerability, Cosmetic Outcome, and Patient Satisfaction

5% 5-Fluorouracil Cream for the Treatment of Small Superficial Basal Cell Carcinoma: Efficacy, Tolerability, Cosmetic Outcome, and Patient Satisfaction

Guidelines for practical use of MAL‐PDT in non‐melanoma skin cancer

Adverse effects of topical photodynamic therapy

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