Photodynamic therapy for recurrent hyphema after proton beam radiotherapy of iris melanoma

Abstract

Our case demonstrates that the vascular abnormalities following irradiation of iris melanoma may respond favorably to PDT in selected cases. To our knowledge, this is the first reported case in which PDT was used to treat recurrent hyphema caused by abnormal intralesional blood vessels after proton beam irradiation of iris melanoma.

Phototherapy of Uveal Melanoma

“…Verteporfi n is contraindicated if the patient suffers from hepatic insuffi ciency or porphyria, and during pregnancy. Secondary photodynamic therapy can be administered for exudative choroidal melanoma after radiotherapy and for recurrent hyphema from an irradiated iris melanoma [ 33 ].…”

Expression of Matrix Metalloproteinases and Theirs Tissue Inhibitors in Fibroblast Cultures and Colo-829 and SH-4 Melanoma Cultures After Photodynamic Therapy

“…Other cases of PDT application in the available literature concern patients with melanoma of the sight apparatus, lesions in the nasal area and sensitive parts of the face. There are also reports of successfully concluded therapies of iris melanoma [70], as well as descriptions of 14 patients with metastatic melanoma (13 of them previously treated with other methods) in which cases a successful elimination of all neoplastic cells was achieved after one treatment with PDT-chlorin e6 (in 8 cases) or after a series of therapeutic procedures (in 6 cases) [71].…”

Proton beam radiotherapy for uveal melanoma

“…Rarely, recurrent hyphema can arise from the telangiectatic tumor vessels, which can be treated by photodynamic therapy. 13 …”