Photodynamic therapy against common bacteria causing wound and skin infections

Wardlaw, Jennifer L.; Sullivan, T. E.; Lux, Cassie N.; Austin, Frank W.

doi:10.1016/j.tvjl.2011.09.007

Cited by 44 publications

(28 citation statements)

References 19 publications

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“…A single treatment required 2-3 h of light exposure. The data from this particular study suggested that PDT may be a possible treatment option for wound infections, but repeated treatments or alterations in the photosensitiser or its carrier may be required to decrease treatment times 41 . The aim of this critical review is to discuss surgical site infections in orthopaedic surgery.…”

Section: Prophylactic Antimicrobials and Resistancementioning

confidence: 87%

“…PDT of Gram-positive and Gram-negative bacteria in animal models hasproven to be as successful as in in vitro studies in inactivating the causative bacteria [41][42][43][44][45][46] . As yet, clinical PDT for infections has been mainly in the field of dermatology using 5-aminolevulanic acid (5-ALA) and in dentistry using phenothiazinium dyes-a study concluded after peer-reviewing the published literature between 1960 and 2011.…”

Section: Prophylactic Antimicrobials and Resistancementioning

confidence: 99%

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Surgical site infections subjected to photodynamic therapy: a potential application in orthopaedic surgery

Jerjes¹,

Tan²,

Hopper³

et al. 2012

Hard Tissue

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Introduction Photodynamic therapy, a minimally invasive oncological modality, has been in use for over 20 years. However, little clinical data is available on its non-oncological efficacy. Several laboratory-based trials on animals have suggested that this technology may be applicable as an antimicrobial therapy. In orthopaedics, where implants and metal work are placed in deep tissue planes, a potential risk of infection is treated very seriously. Infection not only increases patient morbidity and mortality but also the burden on healthcare system. Proposing a new modality that can instantly tackle this problem. This critical review discusses surgical site infections subjected to photodynamic therapy. Conclusion Surgical care should be state of the art with careful attention to strategies that avoid the development of SSIs. When SSI does occur, superficial and deep wound infections can be treated using PDT by applying topical photosensitiser to the area followed by light illumination.

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Section: Prophylactic Antimicrobials and Resistancementioning

confidence: 87%

Section: Prophylactic Antimicrobials and Resistancementioning

confidence: 99%

Surgical site infections subjected to photodynamic therapy: a potential application in orthopaedic surgery

Jerjes¹,

Tan²,

Hopper³

et al. 2012

Hard Tissue

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“…FS ajan olarak kullanılabilecek yüzlerce bileşen keş-fedilmiştir. Bunlardan yaygın olarak kullanılanlar akridin boyaları, riboflavin, proflavin, metilen mavisi, toluidin mavisi O (TBO), floresan, eritrozin, porfirin, klorofil, filoeritrin, ftalosiyaninler ve türevleridir (16,42,47,48) .…”

Section: Fotodinamik Antimikrobiyal Tedavinin Etki Mekanizmasıunclassified

“…Fotofrin, aminolevulinik asit (ALA), verteporfirin, meso-tetra-hidroksifenil-klorin, çinko ftalosiyanin, silikon naftalosiyanin, N-propil porfisin gibi daha yüzlerce ışıkla aktive olabilen ve hücrede reaktif oksijen üretebilecek bileşik mevcuttur. Bu bileşiklerin birçoğu başta kanser olmak üzere, tümör vakaların-da, ağız, diş ve deri hastalıklarında kullanılmaktadır (27,35,42,48) . Diş tedavilerinde, ağız içi mikroorganizmaların kontrolünün sağlanmasında antibiyotik kullanımı son derece yaygındır.…”

Section: Fotodinamik Antimikrobiyal Tedavinin Kullanım Alanlarıunclassified

“…Bu nedenle, mikroorganizmaların hücre dışı yapılarındaki farklı-lıklar seçilen FS'i spesifik kılmaktadır (18,30,34) . Gram negatif ve Gram pozitif bakterilerin hücre duvarı yapısındaki farklılıklar, bu organizmaların farklı elektriksel yükteki FS ile farklı etkileşimlerin oluşmasına neden olmaktadır (18,48) . Anyonik ve nötral FS Gram pozitif bakterilere etkili bir şekilde bağla-nıp, görünür ışıkta bakterileri inhibe ederken, Gram negatiflerin aynı dozda ve ışıkta inhibisyona uğramadıkları gözlenmiştir.…”

Section: Fotoantimikrobiyallerin Mikroorganizmalara Etkisiunclassified

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Photoantimicrobials and Photodynamic Antimicrobial Therapy in Search of Antibiotics

Börekçi¹,

Eliuz²

2017

Ankem Derg

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Regioselective Synthesis and Photophysical and Electrochemical Studies of 20‐Substituted Cyanine Dye–Purpurinimide Conjugates: Incorporation of Ni^II into the Conjugate Enhances its Tumor‐Uptake and Fluorescence‐Imaging Ability

Ethirajan

Chen

Ohulchanskyy

et al. 2013

Chemistry A European J

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We report herein a simple and efficient approach to the synthesis of a variety of meso-substituted purpurinimides. The reaction of meso-substituted purpurinimide with N-bromosuccinimide regioselectively introduced a bromo functionality at the 20-position, which on further reaction with a variety of boronic acids under Suzuki reaction conditions yielded the corresponding meso-substituted analogues. Interestingly, the free base and the metalated analogues showed remarkable differences in photosensitizing efficacy (PDT) and tumor-imaging ability. For example, the free-base conjugate showed significant in vitro PDT efficacy, but limited tumor avidity in mice bearing tumors, whereas the corresponding Ni(II) derivative did not produce any cell kill, but showed excellent tumor-imaging ability at a dose of 0.3 μmol kg(-1) at 24, 48, and 72 h post-injection. The limited PDT efficacy of the Ni(II) analogue could be due to its inability to produce singlet oxygen, a key cytotoxic agent required for cell kill in PDT. Based on electrochemical and spectroelectrochemical data in DMSO, the first one-electron oxidation (0.52 V vs. SCE) and the first one-electron reduction (-0.57-0.67 V vs. SCE) of both the free base and the corresponding Ni(II) conjugates are centered on the cyanine dye, whereas the second one-electron reduction (-0.81 V vs. SCE) of the two conjugates is assigned to the purpurinimide part of the molecule. Reduction of the cyanine dye unit is facile and occurs prior to reduction of the purpurinimide group, which suggests that the cyanine dye unit as an oxidant could be the driving force for quenching of the excited triplet state of the molecules. An interaction between the cyanine dye and the purpurinimide group is clearly observed in the free-base conjugate, which compares with a negligible interaction between the two functional groups in the Ni(II) conjugate. As a result, the larger HOMO-LUMO gap of the free-base conjugate and the corresponding smaller quenching constant is a reason to decrease the intramolecular quenching process and increase the production of singlet oxygen to some degree.

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Photodynamic therapy against common bacteria causing wound and skin infections

Cited by 44 publications

References 19 publications

Surgical site infections subjected to photodynamic therapy: a potential application in orthopaedic surgery

Surgical site infections subjected to photodynamic therapy: a potential application in orthopaedic surgery

Photoantimicrobials and Photodynamic Antimicrobial Therapy in Search of Antibiotics

Regioselective Synthesis and Photophysical and Electrochemical Studies of 20‐Substituted Cyanine Dye–Purpurinimide Conjugates: Incorporation of Ni^II into the Conjugate Enhances its Tumor‐Uptake and Fluorescence‐Imaging Ability

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Photodynamic therapy against common bacteria causing wound and skin infections

Cited by 44 publications

References 19 publications

Surgical site infections subjected to photodynamic therapy: a potential application in orthopaedic surgery

Surgical site infections subjected to photodynamic therapy: a potential application in orthopaedic surgery

Photoantimicrobials and Photodynamic Antimicrobial Therapy in Search of Antibiotics

Regioselective Synthesis and Photophysical and Electrochemical Studies of 20‐Substituted Cyanine Dye–Purpurinimide Conjugates: Incorporation of NiII into the Conjugate Enhances its Tumor‐Uptake and Fluorescence‐Imaging Ability

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Resources

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Regioselective Synthesis and Photophysical and Electrochemical Studies of 20‐Substituted Cyanine Dye–Purpurinimide Conjugates: Incorporation of Ni^II into the Conjugate Enhances its Tumor‐Uptake and Fluorescence‐Imaging Ability