Photodynamic opening of blood-brain barrier

Semyachkina-Glushkovskaya, Oxana; Kurths, Jürgen; Borisova, Ekaterina; Sokolovski, Sergei G.; Mantareva, Vanya; Ангелов, Иван; Shirokov, Alexander; Navolokin, Nikita; Shushunova, Natalia A.; Khorovodov, Alexander; Ulanova, M.; Sagatova, Madina; Agranivich, Ilana; Sindeeva, Olga A.; Gekalyuk, Artem; Bodrova, Anastasiya; Rafailov, Edik U.

doi:10.1364/boe.8.005040

Cited by 52 publications

(53 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Note that high radiant exposure (40 J/cm 2 ) caused severe vasogenic edema after PDT for both young and adult mice. This fact suggests that high radiant exposure induces BBB disruption beyond the brain reserve capability, which agrees with our previous results [7].…”

Section: Discussionsupporting

confidence: 93%

“…In our previous studies on adult mice, we demonstrated that PDT temporally increases BBB permeability . Our results are consistent with data of Hirschberg et al and Madsen et al, who also showed PDT‐related BBB opening using a 400 μm bare flat‐end quartz fiber (635 nm) with 5‐ALA and 670 nm laser application with aluminum phthalocyanine disulfonate (AlPcS2a) .…”

Section: Introductionsupporting

confidence: 92%

“…In our previous studies on adult mice, we demonstrated that PDT temporally increases BBB permeability [7,8].…”

Section: Introductionmentioning

confidence: 82%

“…In this work, another important approach for minimizing negative consequences of PDT effects to the brain vasculature and tissues is the application of the skull optical clearing technique [32,52,53]. Generally, PDT performance requires a craniotomy in both clinical and fundamental studies due to the high scattering property of the skull, which leads to low light penetration into the brain [7,9,10,[54][55][56]. However, the craniotomy leads to brain swelling, increasing in intracranial pressure and cortical inflammation [10].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Age differences in photodynamic therapy‐mediated opening of the blood‐brain barrier through the optical clearing skull window in mice

Zhang

Feng

et al. 2019

Lasers Surg Med

View full text Add to dashboard Cite

Background Photodynamic therapy (PDT), a minimally invasive therapeutic tool, has been an important option for post‐surgical treatment of malignant gliomas (MGs) in both adult and young patients. Recent studies have shown that PDT can also open the blood‐brain barrier (BBB). However, there are no optimized parameters of PDT for patients at different ages. To determine whether there are age differences in PDT effects on the BBB, we studied PDT‐related BBB opening through the optical clearing skull window in healthy 4‐ and 8‐week‐old mice. Methods In this work, we realized BBB opening by combining PDT with the optical clearing skull window by using different radiant exposures (635 nm, 10–20–30–40 J/cm2) and 5‐aminole‐vulinic acid (5‐ALA, 20 mg/kg). Then, we evaluated BBB permeability by: (i) spectrofluorimetric measuring of Evans Blue dye (EBd) leakage; (ii) confocal imaging of 70 kDa FITC‐dextran extravasation and the BBB integrity; and (iii) histological analysis of brain tissues. Results Using the skull optical clearing method, we demonstrated PDT‐induced BBB opening to EBd and FITC‐dextran in a radiant exposure manner. The histological analysis revealed the different severities of vasogenic edema corresponding to radiant exposures. Besides, the PDT‐related increase in the BBB permeability to high weight molecules (EBd and FITC‐dextran) and solutes (vasogenic edema) was more pronounced in 4‐week‐old mice than in 8‐week‐old mice. Conclusions The more pronounced PDT‐induced BBB disruption in juvenile mice compared with adult mice suggests age differences in PDT‐related BBB opening. This might be an important informative platform for a new application of PDT as a method for brain drug delivery, especially for post‐surgical treatment of MGs. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionsupporting

confidence: 92%

“…In our previous studies on adult mice, we demonstrated that PDT temporally increases BBB permeability [7,8].…”

Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Age differences in photodynamic therapy‐mediated opening of the blood‐brain barrier through the optical clearing skull window in mice

Zhang

Feng

et al. 2019

Lasers Surg Med

View full text Add to dashboard Cite

show abstract

“…Indeed, currently over 70 different methods were suggested for overcoming BBB including physical, chemical and biological approaches [4][5][6] . Nevertheless, these methods are not widely applied in daily clinical practice due to many reasons including invasiveness (e.g., photodynamic opening of BBB that requires skull opening) 7 , challenge in performing (intraarterial injection of mannitol that only few specialists in clinics can usually do) 8 , limitation of drug concentration (intranasal drug delivery) 9 or small area of treatment (only 1-3 mm at usage of focused ultrasound that opens BBB with additional using of micro-bubbles) 10 . All these methods require further studies to improve the reproducibility and technological robustness as well as quantitative evaluation of BBB permeability.…”

mentioning

confidence: 99%

Loud music and the specific sound stress open the blood-brain barrier: new fundamental, biomedical, and social aspects

Semyachkina-Glushkovskaya

Чехонин

Bragin³

et al. 2018

Preprint

View full text Add to dashboard Cite

The blood-brain barrier (BBB) poses a significant challenge for drug brain delivery. The limitation of our knowledge about the nature of BBB explains the slow progress in the therapy of brain diseases and absence of methods for drug brain delivery in the clinical practice.Here we show that BBB opens for low/high weight molecules and nanocarriers after exposure of loud music/sound of 90 dB and 100 dB (regardless its frequency) as being easily produced by MP3/MP4 players, kitchen appliances, loudspeakers at concerts. The role of sound, sound-induced stress and molecular mechanisms behind is discussed in the framework of BBB opening as an informative platform for a novel fundamental knowledge about the nature of BBB and for the development of a non-invasive brain drug delivery technology.Social aspects of music/sound-induced opening of BBB provide completely new information about noise and healthy life conditions that will stimulate new research in this field.

show abstract

Drug Permeability: From the Blood–Brain Barrier to the Peripheral Nerve Barriers

Sun

Zabihi

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

Drug delivery into the peripheral nerves and nerve roots has important implications for effective local anesthesia and treatment of peripheral neuropathies and chronic neuropathic pain. Similar to drugs that need to cross the blood–brain barrier (BBB) and blood–spinal cord barrier to gain access to the central nervous system (CNS), drugs must cross the peripheral nerve barriers (PNBs), formed by the perineurium and blood–nerve barrier to modulate peripheral axons. Despite significant progress made to develop effective strategies to enhance BBB permeability in therapeutic drug design, efforts to enhance drug permeability and retention in peripheral nerves and nerve roots are relatively understudied. Guided by knowledge describing structural, molecular, and functional similarities between restrictive neural barriers in the CNS and peripheral nervous system, it is hypothesized that certain CNS drug delivery strategies are adaptable for peripheral nerve drug delivery. Here, the molecular, structural, and functional similarities and differences between the BBB and PNB are described, existing CNS and peripheral nerve drug delivery strategies are summarized and compared, and the potential application of selected CNS delivery strategies to improve efficacious drug entry for peripheral nerve disorders is discussed.

show abstract

Photodynamic opening of blood-brain barrier

Cited by 52 publications

References 31 publications

Age differences in photodynamic therapy‐mediated opening of the blood‐brain barrier through the optical clearing skull window in mice

Age differences in photodynamic therapy‐mediated opening of the blood‐brain barrier through the optical clearing skull window in mice

Loud music and the specific sound stress open the blood-brain barrier: new fundamental, biomedical, and social aspects

Drug Permeability: From the Blood–Brain Barrier to the Peripheral Nerve Barriers

Contact Info

Product

Resources

About