Loud music and the specific sound stress open the blood-brain barrier: new fundamental, biomedical, and social aspects

Semyachkina-Glushkovskaya, Oxana; Чехонин, В. П.; Bragin, Denis E; Bragina, Olga; Водовозова, Е. Л.; Алексеева, А. С.; Salmin, Vladimir V.; Моргун, А. В.; Malinovskaya, N. A.; Осипова, Е. Д.; Boytsova, E. B.; Tohidpour, Abolghasem; Shirokov, Alexander; Navolokin, Nikita A.; Yang, Yirong; Zhang, Chao; Feng, Wei; Abdurashitov, Arkady S.; Ulanova, Mariya; Shushunova, Natalia A.; Khorovodov, Alexander; Terskov, Andrey; Shareef, Ali Esmat; Pavlov, A. S.; Luo, Qi; Zhu, Dan; Tuchin, Valery V.; Kurths, Jüergen

doi:10.1101/509042

Cited by 3 publications

(5 citation statements)

References 55 publications

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“…Studies varied between intensity and exposure time to music, sound, or noise. Semyachkina-Glushkovskaya et al [ 20 ] showed that music/sound exposure had different effects at 70 dB vs. 90 and 100 dB and at 1-h durations vs. 4- and 24-h durations. The lower stimulus had a similar effect on BBB permeability as the control group (no music/sound stimulus), whereas both 90- and 100-dB exposure increased BBB permeability.…”

Section: Resultsmentioning

confidence: 99%

“…The studies mentioned above showed that music affects the function and health of the body and brain, autonomic and cognitive function, and neuronal function and health, often positively. In addition, there is preliminary evidence regarding the effects of music/sound on the activity of the glymphatic system [ 19 , 20 ]. Several studies have also researched the effects of ultrasound on glymphatic clearance [ 21 , 22 , 23 ].…”

Section: Purposementioning

confidence: 99%

“…Another study exposed mice to Scorpions’ “Still Loving You” at 100 dB [ 20 ]. One hour after music exposure, BBB permeability increased 17.3-fold.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance

et al. 2022

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The meningeal lymphatic, or glymphatic, system is receiving increasing attention from the scientific community. Recent work includes noninvasive techniques to demonstrate relationships between blood–brain barrier (BBB) activity and the glymphatic system in the human central nervous system. One potential technique is the use of music/sound to enhance BBB permeability regarding the movement of small molecules in and out of the brain. However, there is minimal knowledge regarding the methodical investigation(s) of the uses of music/sound on BBB permeability and glymphatic clearance and the outcomes of these investigation(s). This review contains evidence discussing relationships between music/sound, BBB permeability, and meningeal lymphatic clearance. An overview of the anatomy and physiology of the system is presented. We discuss the uses of music/sound to modulate brain and body functions, highlighting music’s effects on mood and autonomic, cognitive, and neuronal function. We also propose implications for follow-up work. The results showed that music and sound interventions do, in fact, contribute to the opening of the BBB and subsequently increase the function of the meningeal lymphatic system. Evidence also suggests that music/sound has the ability to reduce the collateral effects of brain injuries. Unfortunately, music/sound is rarely used in the clinical setting as a medical intervention. Still, recent research shows the potential positive impacts that music/sound could have on various organ systems.

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Section: Resultsmentioning

confidence: 99%

Section: Purposementioning

confidence: 99%

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Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance

et al. 2022

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“…To get the training SNR examples, we used EEG signals before (EEG1) and after (EEG2) artificially increased permeability of the BBB [55]. During the training, the fragments of SNR for the rat after music stimulation were marked as the expected response "1" (i.e.…”

Section: Ann Based Methodsmentioning

confidence: 99%

Non-invasive analysis of blood-brain barrier permeability based on wavelet and machine learning approaches

Semenova,

Segreev,

Slepnev

et al. 2021

Preprint

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The blood-brain barrier plays a decisive role in protecting the brain from toxins and pathogens. The ability to analyze the BBB opening (OBBB) is crucial for the treatment of many brain diseases, but it is very difficult to noninvasively monitor OBBB. In this paper we analyse the EEG series of healthy rats in free behaviour and after music-induced OBBB. The research is performed using two completely different methods based on wavelet analysis and machine learning approach. Both methods enable us to recognize OBBB and are in a good agreement with each other. The comparative analysis was carried out using F-measures and ROC-curves.

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“…The further equipment details can be found in [40], while the extended discussion of the method validation and the results obtained can be found in [42,43].…”

Section: Experimental Datamentioning

confidence: 99%

Diffusion assessment through image processing: beyond the point-source paradigm

Postnikov

Nаmykin

Semyachkina-Glushkovskaya

et al. 2021

Eur. Phys. J. Plus

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The quantification of transport processes of different substances in the brain's parenchyma is important in the context of understanding brain functioning. Most of the currently used methods for assessment of the effective diffusion coefficient rely on the pointsource paradigm. We propose a method for the quantitative characterization of the diffusion process in the brain's parenchyma using a set of images recorded during the spreading of a fluorescent dye. Our method uses the frame-by-frame comparison of such images with a set of computed images that would be observed for an ideal diffusion process within the same topology of the tissue's part. We obtain this reference set of images using blurring the image with an appropriate kernel function, and the degree of such blurring correlates with the parameters of a dye spreading process and the transport coefficients. We demonstrate the applicability of the proposed method using (i) the simulated surrogate data, (ii) the set of fluorescent images of the isolated event of blood-brain barrier opening, and (iii) the images of massive multi-source spreading of fluorescent dye. Focus Point on Breakthrough Optics-and Complex Systems-based Technologies of Modulation of Drainage and Clearing Functions of the Brain Guest editors: J.

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Loud music and the specific sound stress open the blood-brain barrier: new fundamental, biomedical, and social aspects

Cited by 3 publications

References 55 publications

Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance

Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance

Non-invasive analysis of blood-brain barrier permeability based on wavelet and machine learning approaches

Diffusion assessment through image processing: beyond the point-source paradigm

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