Photodynamic inactivation of circulating tumor cells: An innovative approach against metastatic cancer

Raschpichler, Michael; Preis, Eduard; Pinnapireddy, Shashank Reddy; Baghdan, Elias; Pourasghar, Marcel; Schneider, Marc

doi:10.1016/j.ejpb.2020.10.003

Cited by 13 publications

(12 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Minimally invasive therapeutic intravenous catheters with anti-EpCAM antibodies and interiors filled with black phosphorus nanosheets kill CTCs by photothermal effect [151]. Curcumin loaded poly(lactic-co-glycolic acid) nanoparticles and laser irradiation (λ = 447 nm, P = 100 mW) result in photodynamic inactivation of CTCs [152]. Electrostatic charge stimulation (PPECS) of the whole blood selectively deactivates the invasive function of CTCs and suppresses pulmonary metastasis of 4T1 breast cancer cells and extended survival in an in vivo model [153].…”

Section: Other Methods For Ctc Eradicationmentioning

confidence: 99%

Metastasis Prevention: Focus on Metastatic Circulating Tumor Cells

et al. 2021

View full text Add to dashboard Cite

Metastasis is the main cause of cancer death. Metastatic foci are derived from tumor cells that detach from the primary tumor and then enter the circulation. Circulating tumor cells (CTCs) are generally associated with a high probability of distant metastasis and a negative prognosis. Most CTCs die in the bloodstream, and only a few cells form metastases. Such metastatic CTCs have a stem-like and hybrid epithelial-mesenchymal phenotype, can avoid immune surveillance, and show increased therapy resistance. Targeting metastatic CTCs and their progenitors in primary tumors and their descendants, particularly disseminated tumor cells, represents an attractive strategy for metastasis prevention. However, current therapeutic strategies mainly target the primary tumor and only indirectly affect metastasis-initiating cells. Here, we consider potential methods for preventing metastasis based on targeting molecular and cellular features of metastatic CTCs, including CTC clusters. Also, we emphasize current knowledge gaps in CTC biology that should be addressed to develop highly effective therapeutics and strategies for metastasis suppression.

show abstract

Section: Other Methods For Ctc Eradicationmentioning

confidence: 99%

Metastasis Prevention: Focus on Metastatic Circulating Tumor Cells

et al. 2021

View full text Add to dashboard Cite

show abstract

“…After each irradiation time, the absorbance spectra were measured at λmax = 434 nm (Multiskan GO, Thermo Scientific, Waltham, MA, USA). The absorbance spectra were normalized for better comparison, and PTN's remaining percentage was calculated and compared with free PTN [37].…”

Section: Photostability Of Inclusion Complexesmentioning

confidence: 99%

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

et al. 2022

Self Cite

View full text Add to dashboard Cite

Multidrug resistance in pathogenic bacteria has become a significant public health concern. As an alternative therapeutic option, antimicrobial photodynamic therapy (aPDT) can successfully eradicate antibiotic-resistant bacteria with a lower probability of developing resistance or systemic toxicity commonly associated with the standard antibiotic treatment. Parietin (PTN), also termed physcion, a natural anthraquinone, is a promising photosensitizer somewhat underrepresented in aPDT because of its poor water solubility and potential to aggregate in the biological environment. This study investigated whether the complexation of PTN with (2-hydroxypropyl)-β-cyclodextrin (HP-β-CD) could increase its solubility, enhance its photophysical properties, and improve its phototoxicity against bacteria. At first, the solubilization behavior and complexation constant of the PTN/HP-β-CD inclusion complexes were evaluated by the phase solubility method. Then, the formation and physicochemical properties of PTN/HP-β-CD complexes were analyzed and confirmed in various ways. At the same time, the photodynamic activity was assessed by the uric acid method. The blue light-mediated photodegradation of PTN in its free and complexed forms were compared. Complexation of PTN increased the aqueous solubility 28-fold and the photostability compared to free PTN. PTN/HP-β-CD complexes reduce the bacterial viability of Staphylococcus saprophyticus and Escherichia coli by > 4.8 log and > 1.0 log after irradiation, respectively. Overall, the low solubility, aggregation potential, and photoinstability of PTN were overcome by its complexation in HP-β-CD, potentially opening up new opportunities for treating infections caused by multidrug-resistant bacteria.

show abstract

“…PDT determined alterations in the cancer cells, i.e., apoptosis and prompt necrosis, as a function of time, and during laser activation of curcumin nanoparticles, a change in blue absorption spectra and a decrease in total curcumin occurred. Findings are incentive for the extension of these in vitro CTCs studies to in vivo experiments, so that PDT becomes an advanced action plan for future clinical applications for metastasis prevention [102].…”

Section: Breast Cancermentioning

confidence: 99%

“…Table 1 summarizes aspects of recent research that have shown that curcumin nano formulations, together with PDT, can contribute to the treatment of breast cancer by strong penetration into cancer cells, high cytotoxic potential, decreased tumor volume, prevention of metastases, without weight loss, and without adverse effects on vital organs (liver and lungs) in experimental animals, with prospects for future clinical applications [94,98,102,103,109,110]. [110]…”

Section: Breast Cancermentioning

confidence: 99%

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Ailioaie

Litscher

2021

Pharmaceutics

View full text Add to dashboard Cite

In the context of the high incidence of cancer worldwide, state-of-the-art photodynamic therapy (PDT) has entered as a usual protocol of attempting to eradicate cancer as a minimally invasive procedure, along with pharmacological resources and radiation therapy. The photosensitizer (PS) excited at certain wavelengths of the applied light source, in the presence of oxygen releases several free radicals and various oxidation products with high cytotoxic potential, which will lead to cell death in irradiated cancerous tissues. Current research focuses on the potential of natural products as a superior generation of photosensitizers, which through the latest nanotechnologies target tumors better, are less toxic to neighboring tissues, but at the same time, have improved light absorption for the more aggressive and widespread forms of cancer. Curcumin incorporated into nanotechnologies has a higher intracellular absorption, a higher targeting rate, increased toxicity to tumor cells, accelerates the activity of caspases and DNA cleavage, decreases the mitochondrial activity of cancer cells, decreases their viability and proliferation, decreases angiogenesis, and finally induces apoptosis. It reduces the size of the primary tumor, reverses multidrug resistance in chemotherapy and decreases resistance to radiation therapy in neoplasms. Current research has shown that the use of PDT and nanoformulations of curcumin has a modulating effect on ROS generation, so light or laser irradiation will lead to excessive ROS growth, while nanocurcumin will reduce the activation of ROS-producing enzymes or will determine the quick removal of ROS, seemingly opposite but synergistic phenomena by inducing neoplasm apoptosis, but at the same time, accelerating the repair of nearby tissue. The latest curcumin nanoformulations have a huge potential to optimize PDT, to overcome major side effects, resistance to chemotherapy, relapses and metastases. All the studies reviewed and presented revealed great potential for the applicability of nanoformulations of curcumin and PDT in cancer therapy.

show abstract

Photodynamic inactivation of circulating tumor cells: An innovative approach against metastatic cancer

Cited by 13 publications

References 57 publications

Metastasis Prevention: Focus on Metastatic Circulating Tumor Cells

Metastasis Prevention: Focus on Metastatic Circulating Tumor Cells

Parietin Cyclodextrin-Inclusion Complex as an Effective Formulation for Bacterial Photoinactivation

Latest Innovations and Nanotechnologies with Curcumin as a Nature-Inspired Photosensitizer Applied in the Photodynamic Therapy of Cancer

Contact Info

Product

Resources

About