Photodynamic inactivation of Candida albicans sensitized by tri- and tetra-cationic porphyrin derivatives

The photodynamic activity of a novel porphyrin derivative bearing a fluconazole structure in different media and against Candida albicans

“…Strain of C. albicans PC31, recovered from human skin lesion, was previously characterized and identified [25]. Cultures of C. albicans were grown aerobically overnight in Sabouraud (Britania, Buenos Aires, Argentina) broth (4 mL) at 37 C to stationary phase.…”

Synthesis and photodynamic properties of amphiphilic A3B-phthalocyanine derivatives bearing N-heterocycles as potential cationic phototherapeutic agents

“…The charge increases the association of the photosensitizer with pathogen membranes, whereas the hydrophobic character increases association with or penetration into the lipid components of the membrane. In general, increasing the number of cationic charges and lowering the hydrophobicity tended to increase the PDI efficiency against bacteria and yeast [7,8].…”

The photodynamic effect of methylene blue and toluidine blue on Candida albicans is dependent on medium conditions

“…This technique involves the production of highly cytotoxic singlet oxygen and other reactive oxygen species, which promoteing photodynamic microbial damage. The photodynamic effects on the pathogen Candida albicans using different photosensitizing drugs have been demonstrated by several authors (Bliss et al, 2004;Chabrier-Roselló et al, 2005;Demidova and Hamblin, 2005;Cormick et al, 2009;So et al, 2009); and the fungicide effects of methylene blue as a photosensitizing drug on the C. albicans was recently demonstrated (Souza et al, 2006;Munin et al, 2007;Peloi et al, 2008). However, in spite of the growing interest in PACT, the specific mechanisms associated with this are not clear.…”