The photodynamic activity of a novel porphyrin derivative bearing a fluconazole structure in different media and against Candida albicans

Mora, Sabrina; Cormick, M. Paula; Milanesio, M. Elisa; Durantini, Edgardo N.

doi:10.1016/j.dyepig.2010.04.001

Cited by 30 publications

(20 citation statements)

References 33 publications

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“…21 It is also worth noting that similar absorption features are observed for protected porphyrins 4 and 5 in MeOH. However, compound 7 forms a green solution in distilled water (pH = 6.2, see Supporting information) and exhibits an intense Q I band and a broadened red-shifted Soret band.…”

Section: Nmr and By Mass Spectrometry (Maldi-tof) (See Supporting Isupporting

confidence: 61%

Novel polycarboxylate porphyrins: Synthesis, characterization, photophysical properties and preliminary antimicrobial study against Gram-positive bacteria

Jiblaoui

Leroy‐Lhez

Ouk

et al. 2015

Bioorganic & Medicinal Chemistry Letters

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Section: Nmr and By Mass Spectrometry (Maldi-tof) (See Supporting Isupporting

confidence: 61%

Novel polycarboxylate porphyrins: Synthesis, characterization, photophysical properties and preliminary antimicrobial study against Gram-positive bacteria

Jiblaoui

Leroy‐Lhez

Ouk

et al. 2015

Bioorganic & Medicinal Chemistry Letters

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“…The photodynamic inactivation of fungi is usually considered as requiring higher PS concentrations than the inactivation of bacterial cells . However, efficient photodynamic inactivation of C. albicans, either in cell suspensions or biofilms, has been demonstrated with different photosensitizers, namely, phenothiazine dyes , Photofrin ® , aminolevulinic acid , di‐, tri‐ and tetracationic porphyrin derivatives , a porphyrin‐fluconazole conjugate , and even endogenous porphyrins . Antifungal‐resistant strains, such as pathogenic respiratory deficient mutants of C. albicans, that are usually resistant to azole antifungals, have also been efficiently photosensitized .…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Inactivation of Bacterial and Yeast Biofilms With a Cationic Porphyrin

Beirão

Fernandes

Coelho

et al. 2014

Photochem & Photobiology

110

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The efficiency of 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetra-iodide (Tetra-Py(+)-Me) in the photodynamic inactivation of single-species biofilms of Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans and mixed biofilms of S. aureus and C. albicans was evaluated. The effect on the extracellular matrix of P. aeruginosa was also assessed. Irradiation with white light up to an energy dose of 64.8 J cm(-2) in the presence of 20 μm of Tetra-Py(+)-Me caused significant inactivation in all single-species biofilms (3-6 log reductions), although the susceptibility was attenuated in relation to planktonic cells. In mixed biofilms, the inactivation of S. aureus was as efficient as in single-species biofilms but the susceptibility of C. albicans decreased. In P. aeruginosa biofilms, a reduction of 81% in the polysaccharide content of the matrix was observed after treatment with a 20 μm PS concentration and a total light dose of 64.8 J cm(-2). The results show that the Tetra-Py(+)-Me causes significant inactivation of the microorganisms, either in biofilms or in the planktonic form, and demonstrate that polysaccharides of the biofilm matrix may be a primary target of photodynamic damage.

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“…The haematoporphyrin [57], Photofrin [58,59], meso-tetrakis(N-methyl-6-quinolinyl)-substituted porphyrins and chlorins [60], cationic derivatives of meso-tetrapyridylporphyrin [61], porphyrin derivatives bearing a fluconazole unit [62] and ALA [63] are some of the PS used in vitro assays that efficiently inactivate C. albicans.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Inactivation of Candida albicans in Blood Plasma and Whole Blood

Sousa

Gomes

Freitas³

et al. 2019

Antibiotics

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The few approved disinfection techniques for blood derivatives promote damage in the blood components, representing risks for the transfusion receptor. Antimicrobial photodynamic therapy (aPDT) seems to be a promising approach for the photoinactivation of pathogens in blood, but only three photosensitizers (PSs) have been approved, methylene blue (MB) for plasma and riboflavin and amotosalen for plasma and platelets. In this study, the efficiency of the porphyrinic photosensitizer Tri-Py(+)-Me and of the porphyrinic formulation FORM was studied in the photoinactivation of Candida albicans in plasma and in whole blood and the results were compared to the ones obtained with the already approved PS MB. The results show that FORM and Tri-Py(+)-Me are promising PSs to inactivate C. albicans in plasma. Although in whole blood the inactivation rates obtained were higher than the ones obtained with MB, further improvements are required. None of these PSs had promoted hemolysis at the isotonic conditions when hemolysis was evaluated in whole blood and after the addition of treated plasma with these PSs to concentrates of red blood cells.

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The photodynamic activity of a novel porphyrin derivative bearing a fluconazole structure in different media and against Candida albicans

Cited by 30 publications

References 33 publications

Novel polycarboxylate porphyrins: Synthesis, characterization, photophysical properties and preliminary antimicrobial study against Gram-positive bacteria

Novel polycarboxylate porphyrins: Synthesis, characterization, photophysical properties and preliminary antimicrobial study against Gram-positive bacteria

Photodynamic Inactivation of Bacterial and Yeast Biofilms With a Cationic Porphyrin

Photodynamic Inactivation of Candida albicans in Blood Plasma and Whole Blood

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