Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis

Lee, Hong Zin; Yang, Wen; Hour, Mann Jen; Wu, Changming; Peng, Wen; Bao, Bo‐Ying; Han, Ping; Bau, Da Tian

doi:10.1016/j.ejphar.2010.08.033

Cited by 42 publications

(41 citation statements)

References 31 publications

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“…Chen et al (2009) have been recently reported that exposure of monoblastic U937 cells to platonin (a photosensitizer used for photodynamic therapy) caused formation of AVO in treated cells. Intriguingly, it has been observed that AE is a photosensitizer for lung cancer H460 cells (Lee et al, 2010). Since photodynamic therapy for tumors is based on the tumor-selective accumulation of PpIX (also in U937 cells), followed by irradiation with visible light (Amo et al, 2009), the coupling of photodynamic therapy with AE-induced differentiation seems reasonable.…”

Section: Discussionmentioning

confidence: 99%

Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells

et al. 2011

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“…Given the antitumor activity of AE and the potential to be a novel PS, AE-induced PDT (with a low concentration of AE) may be applied as a new therapeutic modality for the treatment of tumor. AE-induced PDT with a lower concentration of AE compared with AE used alone may decrease the aforementioned side effect (acute renal failure) when AE is used alone (14). However, as a potential PS, the effect of AE-induced photodynamic activity on tumor cells has been rarely studied (14).…”

Section: Introductionmentioning

confidence: 99%

“…AE-induced PDT with a lower concentration of AE compared with AE used alone may decrease the aforementioned side effect (acute renal failure) when AE is used alone (14). However, as a potential PS, the effect of AE-induced photodynamic activity on tumor cells has been rarely studied (14). …”

Section: Introductionmentioning

confidence: 99%

The effect of aloe-emodin-induced photodynamic activity on the apoptosis of human gastric cancer cells: A pilot study

Lin

Duan³

et al. 2017

Oncology Letters

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The aim of the present study was to explore the effect of aloe-emodin (AE)-induced photodynamic activity in human gastric cancer cells. AE was used as a photosensitizer to explore the effect of photodynamic therapy (PDT) in human gastric cancer cells (SGC-7901). An MTT assay was used to detect the effect of AE-induced PDT in optimal concentrations and illumination energy densities in human gastric cancer cells. Following AE-induced PDT, morphological changes of the cells and the rate of cell death were evaluated by TUNEL assay and flow cytometry, respectively. The expression levels of caspase-9 and caspase-3 were determined by western blot analysis. The AE and AE-induced PDT demonstrated a significant inhibitive effect on the proliferation of human gastric cancer cells in dose-dependent and energy-dependent manners. For subsequent experiments, 10 µM AE and 12.8 J/cm2 illumination energy density were used. Typical morphological changes of apoptosis were observed in the cells using a TUNEL assay 12 h subsequent to AE-induced PDT. The percentage of apoptotic cells treated with AE-induced PDT significantly increased when compared with the control group, the 10 µM AE group and the illumination group (P<0.05). Upregulation of caspase-9 and caspase-3 protein levels was also observed following AE-induced PDT. The present study revealed that 10 µM AE-induced PDT had an inhibitory effect on human gastric cancer cells, and it may induce cell apoptosis by upregulating caspase-9 and caspase-3, which indicated that the mitochondrial pathway may be involved. AE-induced PDT has the potential to be a novel therapy for the treatment of human gastric cancer. However, further investigations are required.

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“…The cancer cells were treated with fungal extracts for 24 h and then incubated in a serum-free medium containing 0.24 mmol L À1 MTT at 37 C for an additional h. After solubilization of the reduction product of MTT in DMSO (200 mL), the absorbance was measured spectrophotometrically at 550 nm. 33) Three replicates for each treatment and four independent experiments were performed.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Production of Ganoderic Acids and Cytotoxicity ofGanoderma lucidumUsing Solid-Medium Culture

You

Lee

Chung

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis

Cited by 42 publications

References 31 publications

Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells

Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells

The effect of aloe-emodin-induced photodynamic activity on the apoptosis of human gastric cancer cells: A pilot study

Enhanced Production of Ganoderic Acids and Cytotoxicity ofGanoderma lucidumUsing Solid-Medium Culture

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