Photodisinfection Effects of Silver Sulfadiazine Nanoliposomes Doped-Curcumin on
            <i>Acinetobacter Baumannii</i>
            : A Mouse Model

Pourhajibagher, Maryam; Partoazar, Alireza; Alaeddini, Mojgan; Etemad‐Moghadam, Shahroo; Bahador, Abbas

doi:10.2217/nnm-2019-0315

Cited by 28 publications

(21 citation statements)

References 37 publications

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“…Photodisinfection or antimicrobial photodisinfection therapy is a noninvasive technique that uses light irradiation to excite a photosensitizer molecule into a cytotoxic state [ 45 ]. It has been employed for treating oral and other infectious diseases.…”

Section: Discussionmentioning

confidence: 99%

“…This might help reduce transmission of SARS-CoV-2 in addition to decreasing the chance of pulmonary coinfections. Considering that photosensitizers can affect the performance of antimicrobial photodisinfection therapy, evaluating agents like curcumin with anti-inflammatory/antimicrobial activities [ 45 ] could be an intriguing idea for further research. Other studies have also highlighted the importance of reducing salivary viral load and suggested the use of mouthwashes, especially in dental settings [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

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Is SARS-CoV-2 an Etiologic Agent or Predisposing Factor for Oral Lesions in COVID-19 Patients? A Concise Review of Reported Cases in the Literature

Etemad‐Moghadam

Alaeddini

2021

International Journal of Dentistry

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The pathogenic mechanism of SARS-CoV-2 infection is unclear, and its symptoms vary in different patients. Initial reports of COVID-19 concentrated on pulmonary issues, but with time, additional features such as hyposmia/anosmia, dysgeusia, and skin lesions were added to the list of COVID-19 symptoms. There have been an increasing number of reports on oral cavity lesions in individuals with COVID-19, which might be relevant considering that this location is one of the first sites coming into contact with the virus and that it contains the SARS-CoV-2 receptor. We hereby aim to familiarize practicing head and neck clinicians with the range of oral lesions reported in COVID-19 patients and to critically appraise the most recent data on the role of SARS-CoV-2 in these lesions. We also discuss the ongoing debate on the direct/indirect association of oral symptoms with the disease. COVID-19 cases with simultaneous oral symptoms were extracted from the literature, and articles discussing the role of SARS-CoV-2 in oral lesions were compiled and methodically analyzed. We found approximately 95 COVID-19 patients with a wide range of oral lesions. Based on current evidence, the exact role of SARS-CoV-2 in the development of oral lesions remains unclear. Oral examination of patients is needed to provide adequate cases for analysis to clarify unknown problems related to COVID-19. There is evidence to support both the direct and indirect roles of SARS-CoV-2 in the development of oral lesions. Awareness of the possibility of oral manifestations in COVID-19 is important to clarify the range of disease signs and symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Is SARS-CoV-2 an Etiologic Agent or Predisposing Factor for Oral Lesions in COVID-19 Patients? A Concise Review of Reported Cases in the Literature

Etemad‐Moghadam

Alaeddini

2021

International Journal of Dentistry

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“…Due to AgSD local toxicity, a nanoliposomal (NL) form has been proposed to increase the benefit/risk ratio. To enhance the effectiveness of this treatment method for burn wound infections, the AgSD-NL combined with curcumin as a PS was used in the PDI process by [ 159 ]. Photoexcited AgSD-NLs@Cur showed antibacterial and antibiofilm activity against A. baumannii involved in burn wound infections, without any significant cell cytotoxicity and hemolytic activity.…”

Section: Prevention and Treatment Strategies Against A Baumannii Biofilmmentioning

confidence: 99%

“…Photoexcited AgSD-NLs@Cur showed antibacterial and antibiofilm activity against A. baumannii involved in burn wound infections, without any significant cell cytotoxicity and hemolytic activity. This effect was likely secondary to the downregulation of the abaI gene that in A. baumannii is involved in AHL production and biofilm formation [ 159 ].…”

Section: Prevention and Treatment Strategies Against A Baumannii Biofilmmentioning

confidence: 99%

Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way

et al. 2021

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Bacterial biofilms are a serious public-health problem worldwide. In recent years, the rates of antibiotic-resistant Gram-negative bacteria associated with biofilm-forming activity have increased worrisomely, particularly among healthcare-associated pathogens. Acinetobacter baumannii is a critically opportunistic pathogen, due to the high rates of antibiotic resistant strains causing healthcare-acquired infections (HAIs). The clinical isolates of A. baumannii can form biofilms on both biotic and abiotic surfaces; hospital settings and medical devices are the ideal environments for A. baumannii biofilms, thereby representing the main source of patient infections. However, the paucity of therapeutic options poses major concerns for human health infections caused by A. baumannii strains. The increasing number of multidrug-resistant A. baumannii biofilm-forming isolates in association with the limited number of biofilm-eradicating treatments intensify the need for effective antibiofilm approaches. This review discusses the mechanisms used by this opportunistic pathogen to form biofilms, describes their clinical impact, and summarizes the current and emerging treatment options available, both to prevent their formation and to disrupt preformed A. baumannii biofilms.

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“…Curcumin is capable of suppressing the production of reactive oxygen species (ROS) and this capability results from conjugated double bonds (Chikara et al, 2018). The extensive application of curcumin is because of its excellent pharmacological activities including antioxidant (Almatroodi et al, 2020; Mirzaei et al, 2018), anti‐inflammatory (J. Xu, Jia, Chen, & Wang, 2020), antitumor (Hesari et al, 2019; Salehi et al, 2020; Shabaninejad et al, 2020), neuroprotective (J. Wang, 2020), antimicrobial (Pourhajibagher, Partoazar, Alaeddini, Etemad‐Moghadam, & Bahador, 2020), lipid‐modifier (Zhai et al, 2020), antianalgesic (Bulboaca, Bolboaca, Stanescu, Sfrangeu, & Bulboaca, 2017), hepatoprotective (Y. Lu, Wu, Xiang, Li, & Lin, 2020), cardioprotective (Ahmed, Khan, & Mirzaei, 2019; Y. Chen et al, 2020; Hallajzadeh et al, 2019), and osteoprotective (C. Yang et al, 2020). Curcumin has demonstrated great efficacy in the treatment of nonalcoholic fatty liver disease (NAFLD).…”

Section: Pharmacological Profile Of Curcuminmentioning

confidence: 99%

Versatile role of curcumin and its derivatives in lung cancer therapy

Ashrafizadeh

Najafi

Makvandi

et al. 2020

Journal Cellular Physiology

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Lung cancer is a main cause of death all over the world with a high incidence rate. Metastasis into neighboring and distant tissues as well as resistance of cancer cells to chemotherapy demand novel strategies in lung cancer therapy. Curcumin is a naturally occurring nutraceutical compound derived from Curcuma longa (turmeric) that has great pharmacological effects, such as anti‐inflammatory, neuroprotective, and antidiabetic. The excellent antitumor activity of curcumin has led to its extensive application in the treatment of various cancers. In the present review, we describe the antitumor activity of curcumin against lung cancer. Curcumin affects different molecular pathways such as vascular endothelial growth factors, nuclear factor‐κB (NF‐κB), mammalian target of rapamycin, PI3/Akt, microRNAs, and long noncoding RNAs in treatment of lung cancer. Curcumin also can induce autophagy, apoptosis, and cell cycle arrest to reduce the viability and proliferation of lung cancer cells. Notably, curcumin supplementation sensitizes cancer cells to chemotherapy and enhances chemotherapy‐mediated apoptosis. Curcumin can elevate the efficacy of radiotherapy in lung cancer therapy by targeting various signaling pathways, such as epidermal growth factor receptor and NF‐κB. Curcumin‐loaded nanocarriers enhance the bioavailability, cellular uptake, and antitumor activity of curcumin. The aforementioned effects are comprehensively discussed in the current review to further direct studies for applying curcumin in lung cancer therapy.

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Photodisinfection Effects of Silver Sulfadiazine Nanoliposomes Doped-Curcumin on Acinetobacter Baumannii : A Mouse Model

Cited by 28 publications

References 37 publications

Is SARS-CoV-2 an Etiologic Agent or Predisposing Factor for Oral Lesions in COVID-19 Patients? A Concise Review of Reported Cases in the Literature

Is SARS-CoV-2 an Etiologic Agent or Predisposing Factor for Oral Lesions in COVID-19 Patients? A Concise Review of Reported Cases in the Literature

Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way

Versatile role of curcumin and its derivatives in lung cancer therapy

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