Photodegradation of the antibiotic spiramycin studied by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry

Voigt, Melanie; Savelsberg, Christina; Jaeger, Martin

doi:10.1080/02772248.2017.1280039

Cited by 15 publications

(9 citation statements)

References 39 publications

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“…Photoinduced transformation and degradation were monitored using HPLC-MS techniques and plotted as concentration or area-under-the-curve mass signals versus time (c-t). The c-t curves obtained could be best described by first or pseudo-first order kinetics in agreement with previous studies [25,26,36]. The results are presented in Table 2 as kinetic rate constants and quantum efficiencies.…”

Section: Photoinduced Degradation Of Lomefloxacin-kinetic Of Degradationsupporting

confidence: 89%

“…Kinetic analysis of degradation profiles followed first-order or pseudo first-order kinetic models, consecutive and subsequent follow-up reaction models, cf. Equation (1), according to previous studies and theory [26,[32][33][34][35][36][37]. The complete kinetic description is represented in the Supplementary Information.…”

Section: Kinetic Analysis and Determination Of Quantum Efficiency Of mentioning

confidence: 99%

“…The time t act according to Equation (4) represents the decline in activity an antibiotic possesses against bacteria. It can be calculated from kinetic parameters obtained from degradation experiments, i.e., the and the rate constants k and the initial compound concentration c A0 , and the MIC values (see above) [36].…”

Section: Assessment Of Ecotoxicologymentioning

confidence: 99%

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Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

et al. 2020

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Pharmaceuticals in waters represent a worldwide problem of today. Advanced oxidation processes (AOPs) are being researched for elimination of the ecological hazard. Among the substances, the fluoroquinolone antibiotic lomefloxacin was selected for investigation in this study. Lomefloxacin (LOM) was found in the German river Erft. Near and far ultraviolet (UVA, UVC) radiation were used as AOPs and compared for efficiency depending on pH, water matrix, and catalysts. Chemical kinetics description revealed that UVC at pH 8-9 led to the fastest degradation of LOM. The catalysts hydrogen peroxide and titanium dioxide had only limited influence on the degradation rate. Seven novel transformation products were structurally identified by high-resolution higher-order mass spectrometry. Ecotoxicity of the novel and known compounds was assessed by quantitative structure-activity relationship (QSAR) analysis. In addition, irradiation time dependent minimal, and half-maximal inhibitory concentrations (MIC, IC 50 ) of LOM solutions were determined and suggested as ecotoxicological hazard indicators. From MIC and kinetic rate constants, the irradiation time required for compound and activity removal could be predicted.

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Section: Photoinduced Degradation Of Lomefloxacin-kinetic Of Degradationsupporting

confidence: 89%

Section: Kinetic Analysis and Determination Of Quantum Efficiency Of mentioning

confidence: 99%

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Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

et al. 2020

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“…In environmental waters, such as surface water, different degradation velocities and rate constants would be obtained due to light absorbing substances, such as humins. According to the authors' experience, degradation often takes place more slowly, but sometimes at comparable rates 41 56 .…”

Section: Discussionmentioning

confidence: 99%

“…To this purpose, concentration-time (c-t) plot were derived from HPLC-ESI-Q-TOF-MS measurements and compared to chemical kinetics models using MATLAB. The kinetics of the degradation proceeded according to first-order, and the photodegradates were described as intermediate products of a consecutive or subsequent follow-up reaction 27 41 .…”

Section: Introductionmentioning

confidence: 99%

Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation

Voigt¹,

Savelsberg

Jaeger

2018

JoVE

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Monitoring pharmaceuticals throughout the water cycle is becoming increasingly important for the aquatic environment and eventually for human health. Targeted and non-targeted analysis are today's means of choice. Although targeted analysis usually conducted with the help of a triple quadrupole mass spectrometer may be more sensitive, only compounds previously selected can be identified. The most powerful non-targeted analysis is performed through time of flight mass spectrometers (TOF-MS) extended by a quadrupole mass analyzer (Q), as used in this study. Preceded by solid phase extraction and high-performance liquid chromatography (HPLC), the non-targeted approach allows to detect all ionizable substances with high sensitivity and selectivity. Taking full advantage of the Q-TOF-MS instrument, tandem mass spectrometry (MS/MS) experiments accelerate and facilitate the identification while a targeted MS method enhances the sensitivity but relies on reference standards for identification purposes. The identification of four pharmaceuticals from Rhine river water is demonstrated. The Rhine river originates in Tomasee, Graubünden, Switzerland and flows into the North Sea, near Southern Bight, The Netherlands. Its length amounts to 1232.7 km. Since it is of prime interest to effectively eliminate pharmaceuticals from the water cycle, the effect UV-C irradiation is demonstrated on a laboratory scale. This method allows fast degradation of pharmaceuticals, which is exemplarily shown for the macrolide antibiotic erythromycin. Using the above HPLC-Q-TOF-MS method, concentration-time diagrams are obtained for the parent drug and their photodegradation products. After establishing the equations for first-order sequential reactions, computational fitting allows the determination of kinetic parameters, which might help to predict irradiation times and conditions when potentially considered as fourth stage within wastewater treatment.

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Degradation of spiramycin by thermally activated peroxydisulfate: Kinetics study, oxidation products and acute toxicity

Wang

Liu

et al. 2021

Chemical Engineering Journal

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Photodegradation of the antibiotic spiramycin studied by high-performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry

Cited by 15 publications

References 39 publications

Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

Lomefloxacin—Occurrence in the German River Erft, Its Photo-Induced Elimination, and Assessment of Ecotoxicity

Identification of Pharmaceuticals in The Aquatic Environment Using HPLC-ESI-Q-TOF-MS and Elimination of Erythromycin Through Photo-Induced Degradation

Degradation of spiramycin by thermally activated peroxydisulfate: Kinetics study, oxidation products and acute toxicity

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