Photodegradation of inclusion complexes of isradipine with methyl-β-cyclodextrin

Mielcarek, Jadwiga; Daczkowska, Ewa

doi:10.1016/s0731-7085(99)00173-9

Cited by 29 publications

(16 citation statements)

References 15 publications

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“…Some works have been devoted to stability studies of this kind of drugs and mainly involves the photolytic properties of them, including: a UV derivative spectrophotometric study of the photochemical degradation of nisoldipine [4], photodegradation of inclusion complexes of isradipine with methyl-b-cyclodextrin [5], photostability of nifedipine in powder obtained by crushing tablet [6], and effects of photodegradation of nifedipine on dog erythrocyte membranes [7]. Furthermore, screening techniques have been carried out for several 1,4-dihydropyridine drugs and its daylight degradation products using GC-MS [8] and the chemical stability and pharmacokinetics of amlodipine in rabbits by HPLC-UV [9] were evaluated.…”

Section: Introductionmentioning

confidence: 99%

A Selective Voltammetric Method to Follow the Hydrolytic Degradation of Nitrendipine and Nisoldipine

Álvarez‐Lueje¹,

Sturm²,

Núñez‐Vergara³

et al. 2001

Electroanalysis

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The development and application of a differential pulse voltammetric procedure for the hydrolytic degradation kinetic study of two wellknown 1,4-dihydropyridine type drugs, nitrendipine and nisoldipine are presented. The DPV procedure exhibited an adequate selectivity, repeatability and reproducibility with CV lower than 2%. The recoveries were higher than 98% with CV of 1.63% and 1.87% for nitrendipine and nisoldipine, respectively. Hydrolysis of each drug was carried out in ethanol=Britton-Robinson buffer (30=70) at different pHs and at controlled temperature of 40, 60 and 80 C. A significant degradation was observed at alkaline pH ( > pH 8) following a first order kinetic for both drugs. At pH 12 the decay constant values of 4.85 6 10 À2 h À1 for nitrendipine and 3.18 6 10 À2 h À1 for nisoldipine were obtained. Also, activation energies of 18 kcal=mol and 16 kcal=mol for nitrendipine and nisoldipine, respectively, were calculated. Furthermore, for the nitrendipine hydrolytic, degradation test in different solutions for parenteral use were studied. All the tested vehicles significantly increased the degradation of the drug, with the composition of solutions being the most relevant factor rather than the pH.

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Section: Introductionmentioning

confidence: 99%

A Selective Voltammetric Method to Follow the Hydrolytic Degradation of Nitrendipine and Nisoldipine

Álvarez‐Lueje¹,

Sturm²,

Núñez‐Vergara³

et al. 2001

Electroanalysis

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“…The photodegradation process was assessed by UV spectrophotometry, HPLC and HPTLC chromatography. The formation of inclusion complexes of isradipine with M-βCD was proved to increase twice the photostability of the drug [50].…”

Section: Isradipinementioning

confidence: 99%

“…Microspheres allow continuous drug concentration with a corresponding decrease in single dose and a reduced frequency of ) were calculated. Inclusion in CD increased twice the photostability of the drug [50]. Incorporation of nicardipine in CD was evaluated in terms of photostability in aqueous solution under exposure to UV(A)-UV(B) radiations.…”

Section: Photostabilization Approachesmentioning

confidence: 99%

Photodegradation of 1, 4-Dihydropyridine Antihypertensive Drugs: An Updated Review

Luca

Ioele

Spatari

et al. 2018

Int J Pharm Pharm Sci

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ABSTRACT1, 4-dihydropyridine calcium channels blockers (DHPs) are the most commonly used antihypertensive drugs. Unfortunately, these compounds have a significant degradability to light. The oxidation to the pyridine derivative represents the first, and in many cases the only, step of the degradation mechanism. The photodegradation process causes the complete loss of pharmacological activity and may trigger the formation of single and superoxide oxygen species, potentially responsible for phototoxic reactions. Several analytical techniques have been proposed for DHP determination in the presence of their photoproducts. Nowadays, DHPs are all marketed in solid formulations, especially tablets, because photodegradation is particularly fast in solution. Various approaches aimed to protect molecular integrity and therapeutic activity of these drugs from the effects of light are currently studied. This review covers the studies over the last years about photodegradation of the DHPs and the approaches to obtain photostable formulations of these drugs.

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“…in the studies of photostability of DHP derivatives used as calcium channel blockers. The photochemical sensitivity of nifedipine [19] and second generation DHP derivatives such as nitrendipine [20], nimodipine [21], furnidipine [22] nisoldipine [23], amlodipine [24], isradipine [25], nilvadipine [11], felodipine [12] has been analysed by many authors. It has been shown that upon irradiation, the dihydropyridine ring in these DHP derivatives undergoes oxidation leading to formation of photoproducts of aromatic properties.…”

Section: Photoproduct Identificationmentioning

confidence: 99%

Gas chromatography–mass spectrometry identification of photoproducts of hexahydroquinoline derivatives: Potential calcium channel antagonists

Mielcarek

Matłoka

2005

Journal of Chromatography B

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Photodegradation of inclusion complexes of isradipine with methyl-β-cyclodextrin

Cited by 29 publications

References 15 publications

A Selective Voltammetric Method to Follow the Hydrolytic Degradation of Nitrendipine and Nisoldipine

A Selective Voltammetric Method to Follow the Hydrolytic Degradation of Nitrendipine and Nisoldipine

Photodegradation of 1, 4-Dihydropyridine Antihypertensive Drugs: An Updated Review

Gas chromatography–mass spectrometry identification of photoproducts of hexahydroquinoline derivatives: Potential calcium channel antagonists

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