Photodamage pilot study: A double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel

Sefton, John; Kligman, Albert M.; Kopper, Scott C.; Lue, John C.; Gibson, John R.

doi:10.1067/mjd.2000.107938

Cited by 48 publications

(35 citation statements)

References 19 publications

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“…However, tretinoin is slow to work (24 weeks or more). Tarazotene, an acetylenic topical retinoid, improves the irregular hyperpigmentation associated with photoaging and lightening of the pigmented spots (Sefton et al, 2000). Isotretinoin 0.05% showed no significant positive results in 30 Thai melasma patients (Leenutaphong et al, 1999).…”

Section: Retinoidsmentioning

confidence: 99%

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Solano¹,

Briganti²,

Picardo³

et al. 2006

Pigment Cell Research

617

524

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SummaryAn overview of agents causing hypopigmentation in human skin is presented. The review is organized to put forward groups of biological and chemical agents. Their mechanisms of action cover (i) tyrosinase inhibition, maturation and enhancement of its degradation; (ii) Mitf inhibition; (iii) downregulation of MC1R activity; (iv) interference with melanosome maturation and transfer; (v) melanocyte loss, desquamation and chemical peeling. Tyrosinase inhibition is the most common approach to achieve skin hypopigmentation as this enzyme catalyses the rate-limiting step of pigmentation. Despite the large number of tyrosinase inhibitors in vitro, only a few are able to induce effects in clinical trials. The gap between in-vitro and in-vivo studies suggests that innovative strategies are needed for validating their efficacy and safety. Successful treatments need the combination of two or more agents acting on different mechanisms to achieve a synergistic effect. In addition to tyrosinase inhibition, other parameters related to cytotoxicity, solubility, cutaneous absorption, penetration and stability of the agents should be considered. The screening test system is also very important as keratinocytes play an active role in modulating melanogenesis within melanocytes. Mammalian skin or at least keratinocytes/melanocytes co-cultures should be preferred rather than pure melanocyte cultures or soluble tyrosinase.

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Section: Retinoidsmentioning

confidence: 99%

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Solano¹,

Briganti²,

Picardo³

et al. 2006

Pigment Cell Research

617

524

View full text Add to dashboard Cite

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“…Topical tazarotene also induced favorable histologic changes in photodamaged skin, similar to those described in an earlier pilot study and those described for tretinoin. 1,4,10 These changes were significant when compared with baseline and included increases in epidermal thickness and decreases in melanin content. No increases in cellular atypia in either keratinocytes or melanocytes were observed with topical retinoid treatment.…”

Section: Commentmentioning

confidence: 90%

“…The sample size (8 or 9 subjects per treatment group) may have been too small. In an earlier 12-week study 10 of the safety and efficacy of 0.1% tazarotene gel on photodamaged forearm skin, statistically significant smoothening of the skin surface, when compared with baseline, was detected using this method. Optical profilometry results also have been found to be consistent with clinical evaluations in reports 12 of the efficacy of 0.05% tretinoin emollient cream in the treatment of photodamaged facial skin.…”

Section: Commentmentioning

confidence: 99%

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Tazarotene Cream for the Treatment of Facial Photodamage

Kang¹,

Leyden²,

Lowe³

et al. 2001

Arch Dermatol

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“…Isotretinoin and tazarotene were also found to improve photoaging skin changes [60,61]. Epidermal melasma, actinic lentigines and superficial postinflammatory hyperpigmentation also respond to topical tretinoin, either alone or in combination with hydroquinone and hydrocortisone, in conjunction with a broadspectrum sunscreen [3].…”

Section: Skin Photoaging and Disorders Of Pigmentationmentioning

confidence: 99%

Retinoids – Which Dermatological Indications Will Benefit in the Near Future?

Zouboulis¹

2001

Skin Pharmacol Physiol

119

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Retinoids are compounds with pleiotropic functions and a relatively selective targeting of certain skin structures. They are vitamins, because retinol (vitamin A) is not synthesized in the body and must be derived from diet, but also hormones with intracrine activity, because retinol is transformed into molecules that bind to nuclear receptors, exhibit their activity, and are subsequently inactivated. Retinoids exert their effects on target cells by binding and activating nuclear retinoid receptors. Retinoid receptors bind their ligands in form of dimers. Heterodimers can be formed between two different retinoid receptor molecules but also between retinoid X receptors and the vitamin D receptor as well as the triiodothyronin receptor. This fact indicates complex interactions between retinoids and further hormonal signal transduction molecules. Interaction of retinoid receptors with transcriptional factors activated by other signal transduction mechanisms, e.g. AP-1, may provide dissociation of the retinoid effects. Retinoids can exhibit agonistic activity but also be neutral antagonists and inverse agonists. Topical and oral retinol, tretinoin, isotretinoin, and bexarotene, topical alitretinoin, retinaldehyde, motretinide, adapalene, tazarotene, and systemin acitretin compose the list of launched retinoids. Psoriasis and related disorders, congenital disorders of keratinization, acne, photoaging and hypovitaminosis A are classical approved indications of retinoid treatment, whereas cutaneous T-cell lymphoma, AIDS-associated Kaposi’s sarcoma, acute promyelocytic leukemia and actinic lentigines were currently confirmed. In addition, retinoids have been successfully used in several other dermatoses, e.g. epithelial precanceroses and tumors, seborrhea, rosacea and acneiform dermatoses, lichen planus, eosinophilic folliculitis, condylomata accuminata, lichen sclerosus and atrophicus. Highly receptor selective molecules, retinoic acid receptor-β-inducers, AP-1 complex antagonists, and inverse agonists will be probably lead the retinoid development in the near future. New, more effective and less toxic retinoids, alone or in combination with other drugs and new delivery systems may provide therapeutic solutions for benign and malignant proliferative skin diseases, such as psoriasis and non-melanoma tumors, cancer chemoprevention and differentiation therapy.

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Photodamage pilot study: A double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel

Cited by 48 publications

References 19 publications

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Tazarotene Cream for the Treatment of Facial Photodamage

Retinoids – Which Dermatological Indications Will Benefit in the Near Future?

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