Photocontrolled Nuclear-Targeted Drug Delivery by Single Component Photoresponsive Fluorescent Organic Nanoparticles of Acridin-9-Methanol

Jana, Avijit; Saha, Biswajit; Banerjee, Deb Ranjan; Ghosh, Sudip Kumar; Nguyen, Kim Truc; Ma, Xueli; Qu, Qiuyu; Zhao, Yanli; Singh, N. D. Pradeep

doi:10.1021/bc400170r

Cited by 37 publications

(25 citation statements)

References 44 publications

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“…To this end, various specific chemical groups can also be used, which precisely exhibit affinity toward the nucleus. For instance, Jana et al 194 synthesized acridine-benzbutyrate nitrogen mustard nanoparticles, which combined the DNA with the DNA alkylation group to target at nucleus by the acridine molecule.…”

Section: Active Targeting Using Peptidesmentioning

confidence: 99%

<p>Subcellular Performance of Nanoparticles in Cancer Therapy</p>

Liu

Han

Kankala

et al. 2020

IJN

110

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With the advent of nanotechnology, various modes of traditional treatment strategies have been transformed extensively owing to the advantageous morphological, physiochemical, and functional attributes of nano-sized materials, which are of particular interest in diverse biomedical applications, such as diagnostics, sensing, imaging, and drug delivery. Despite their success in delivering therapeutic agents, several traditional nanocarriers often end up with deprived selectivity and undesired therapeutic outcome, which significantly limit their clinical applicability. Further advancements in terms of improved selectivity to exhibit desired therapeutic outcome toward ablating cancer cells have been predominantly made focusing on the precise entry of nanoparticles into tumor cells via targeting ligands, and subsequent delivery of therapeutic cargo in response to specific biological or external stimuli. However, there is enough room intracellularly, where diverse small-sized nanomaterials can accumulate and significantly exert potentially specific mechanisms of antitumor effects toward activation of precise cancer cell death pathways that can be explored. In this review, we aim to summarize the intracellular pathways of nanoparticles, highlighting the principles and state of their destructive effects in the subcellular structures as well as the current limitations of conventional therapeutic approaches. Next, we give an overview of subcellular performances and the fate of internalized nanoparticles under various organelle circumstances, particularly endosome or lysosome, mitochondria, nucleus, endoplasmic reticulum, and Golgi apparatus, by comprehensively emphasizing the unique mechanisms with a series of interesting reports. Moreover, intracellular transformation of the internalized nanoparticles, prominent outcome and potential affluence of these interdependent subcellular components in cancer therapy are emphasized. Finally, we conclude with perspectives with a focus on the contemporary challenges in their clinical applicability.

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Section: Active Targeting Using Peptidesmentioning

confidence: 99%

<p>Subcellular Performance of Nanoparticles in Cancer Therapy</p>

Liu

Han

Kankala

et al. 2020

IJN

110

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“…The ester bond in the conjugate can be cleaved upon visible‐light irradiation at 410 nm for 20 min, allowing the release of chlorambucil. Similarly, our group developed several photo‐controlled drug‐release systems . For example, acridin‐9‐methanol was synthesized via two steps, producing nanoparticles with a size of ≈60 nm .…”

Section: Drug/gene Delivery and Therapymentioning

confidence: 99%

“…Similarly, our group developed several photo‐controlled drug‐release systems . For example, acridin‐9‐methanol was synthesized via two steps, producing nanoparticles with a size of ≈60 nm . The presence of acridin enabled the binding of nanoparticles to DNA, ascertained by the ethidium bromide displacement assay.…”

Section: Drug/gene Delivery and Therapymentioning

confidence: 99%

Multifunctional Nanoparticles Self‐Assembled from Small Organic Building Blocks for Biomedicine

2016

Self Cite

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Supramolecular self-assembly shows significant potential to construct responsive materials. By tailoring the structural parameters of organic building blocks, nanosystems can be fabricated, whose performance in catalysis, energy storage and conversion, and biomedicine has been explored. Since small organic building blocks are structurally simple, easily modified, and reproducible, they are frequently employed in supramolecular self-assembly and materials science. The dynamic and adaptive nature of self-assembled nanoarchitectures affords an enhanced sensitivity to the changes in environmental conditions, favoring their applications in controllable drug release and bioimaging. Here, recent significant research advancements of small-organic-molecule self-assembled nanoarchitectures toward biomedical applications are highlighted. Functionalized assemblies, mainly including vesicles, nanoparticles, and micelles are categorized according to their topological morphologies and functions. These nanoarchitectures with different topologies possess distinguishing advantages in biological applications, well incarnating the structure-property relationship. By presenting some important discoveries, three domains of these nanoarchitectures in biomedical research are covered, including biosensors, bioimaging, and controlled release/therapy. The strategies regarding how to design and characterize organic assemblies to exhibit biomedical applications are also discussed. Up-to-date research developments in the field are provided and research challenges to be overcome in future studies are revealed.

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“…

A new disulfide-based, imine-linked fluorescent receptor 1 was processed into organic nanoparticles (ONPs) with an average particle size of 79 nm. [6] Singh et al have reported systematic work on ONPs with the use of Biginelli-Based and other Schiff base nanoparticles that disclosed the size-dependent fluorescent properties of organic materials. Receptor 1 selectively recognized Co 2 + ions in water with a detection limit down to 88 nm.

Organic nanoparticles (ONPs) prepared from a variety of materials, including natural products, polymers and biomolecules, have found exciting applications in materials and biological sciences.

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mentioning

confidence: 99%

“…Moreover, ONPs dispersed in water validated the utilize of probes in drug delivery system (DDS) and cellular imaging. [6] Singh et al have reported systematic work on ONPs with the use of Biginelli-Based and other Schiff base nanoparticles that disclosed the size-dependent fluorescent properties of organic materials. [7] For biological and chemical analysis, the probe should be soluble in pure water; however most of the chemosensors are hydrophobic so freshly an innovative concept has been created, which include with the synthesis of ONPs.…”

mentioning

confidence: 99%