Photochemical C–H arylation of heteroarenes for DNA-encoded library synthesis

Abstract

DNA-encoded library (DEL) technology has emerged as a time- and cost-efficient technique for the identification of therapeutic candidates in the pharmaceutical industry. Although several reaction classes have been successfully validated...

Violet‐blue Light Induces “Natural” Photodynamic Plasma Disinfection with Endogenous Sensitizers

“…There are other examples of success with violet and blue light in microbe inactivation (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Even other examples are emerging with violet-blue or blue light in synthetic organic (22)(23)(24)(25)(26)(27)(28) and photopolymerization reactions (29), and naturally, there is a history of blue light therapy in neonatal jaundice (30)(31)(32)(33). Yet, following Maclean and coworker's first accomplishment of microbe reduction to decent levels is the secondary challenge of protecting the sample against protein photooxidation (34)(35)(36)(37).…”

A practical and sustainable two-component Minisci alkylation via photo-induced EDA-complex activation

“…1a). [22][23][24][25] However, despite contemporary advances in this eld, some of the existing Cite this: Chem. Sci., 2022, 13, 5701…”

“…1a). 22–25 However, despite contemporary advances in this field, some of the existing methods still require strong acids for the activation of heterocycles. In addition, a stoichiometric strong oxidant is often needed in conjunction with the photocatalyst, particularly when the reaction is not net-redox neutral.…”

Vinyl azide as a synthon for DNA-compatible divergent transformations into N-heterocycles

“…25–30 While DNA liability to stringent conditions hampers its application in conventional organic synthesis, 31,32 a variety of DNA-compatible reactions have still been successfully developed in recent years to expand the structural complexity of encoded chemical libraries. 33–40…”

“…[25][26][27][28][29][30] While DNA liability to stringent conditions hampers its application in conventional organic synthesis, 31,32 a variety of DNA-compatible reactions have still been successfully developed in recent years to expand the structural complexity of encoded chemical libraries. [33][34][35][36][37][38][39][40] Diversity-oriented synthesis (DOS) represents a fast approach for generating distinct structures based on the uniform intermediate, which is in accordance with the DEL concept. [41][42][43] More structural diversity would undoubtedly increase the chemical space and broaden the structural complexity of the library.…”