Preparation of γ-Fe2O3/ SiO2 aerogel using biogenic silica from rice husk ash (RHA) and the application for photo-Fenton like degradation of rhodamine B (RhB) has been conducted. The synthesis was performed by preparing γ-Fe2O3 nanoparticles followed by sol-gel reaction with silica gel extracted from RHA. The physicochemical properties of γ-Fe2O3/ SiO2 aerogel were characterized by x-ray diffraction (XRD), Fourier Transform-Infra Red (FTIR), diffuse reflectance UV-Visible spectrophotometry, gas sorption analyzer and Scanning Electron Microscopy (SEM) analyses. It is shown that the prepared material exhibits the character supporting photocatalytic activity as shown by UV-Vis absorption spectrum. The photocatalytic activity in photo-Fenton like degradation of RhB reveals that γ-Fe2O3/ SiO2 aerogel demonstrate similar degradation rate compared with γ-Fe2O3 nanoparticles with the advantageous of its reusability that is maintained stably for three cycles.