Photobiomodulation with a combination of two wavelengths in the treatment of oral mucositis in children: The PEDIALASE feasibility study

Noirrit‐Esclassan, Emmanuelle; Valera, Marie-Cécile; Vignes, E.; Munzer, Caroline; Bonal, S.; Daries, M.; Vaysse, Frédéric; Puiseux, C.; Castex, Marie‐Pierre; Boulanger, Christine M.; Pasquet, Marlène

doi:10.1016/j.arcped.2019.05.012

Cited by 15 publications

(17 citation statements)

References 31 publications

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“…In addition to nephrotoxicity, neurotoxicity, and hepatotoxicity, OM has been the focus of many studies due to morbidity association with secondary infections, induction of parenteral nutrition, interference with planned doses, prolongation of hospitalisation, and worsening quality of life 6,9,14 . However, few studies have evaluated these aspects in the paediatric population 9,13,17‐22 . Here, we evaluated in a paediatric population the association between MTX excretion and hepatic and kidney function changes, in order to better understand factors that may be predictive of the onset of OM.…”

Section: Discussionmentioning

confidence: 99%

Oral mucositis in childhood cancer patients receiving high‐dose methotrexate: Prevalence, relationship with other toxicities and methotrexate elimination

Valer

Curra

Gabriel

et al. 2020

Int J Paed Dentistry

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Background Oral mucositis (OM) is one of the main adverse effects of the chemotherapeutic agent methotrexate (MTX). Aim To evaluate the relationship of OM with MTX metabolism time and other toxicities in childhood, cancer patients receiving high‐dose of methotrexate (HD‐MTX). Design Seventy‐seven childhood patients receiving HD‐MTX for treatment of leukaemia, osteosarcoma or lymphoma were evaluated. MTX serum level, hepatic and renal function parameters, and presence and intensity of OM were analysed. Results The patients were submitted to 255 cycles of chemotherapy. OM was diagnosed in 191 (74.9%) cycles. Of these, 119 (46.6%) presented ulcerative lesions. Lymphoma was associated with severe OM (P = .01). OM was associated with higher serum levels of aspartate aminotransferase (P = .006), alanine aminotransferase (P = .04) and creatinine (P = .008). Increase of one unit of total bilirubin and indirect bilirubin associated, respectively, with 11% and 39% higher prevalence of OM. For each increase of one unit of creatinine serum level, it was observed a 37% higher prevalence of OM in patients with lymphoma. No association was found between delayed excretion of MTX and OM development. Conclusions OM is a prevalent complication of childhood cancer patients receiving HD‐MTX. Renal and hepatic toxicity could be considered risk factors for OM, especially in patients with lymphoma.

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Section: Discussionmentioning

confidence: 99%

Oral mucositis in childhood cancer patients receiving high‐dose methotrexate: Prevalence, relationship with other toxicities and methotrexate elimination

Valer

Curra

Gabriel

et al. 2020

Int J Paed Dentistry

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“…Application of LLLT/ PBM as either a prophylactic against OM before chemo and/or radiotherapy or as a treatment for OM have been conducted and results indicated that it was effective in preventing OM, OM grade reduction, and OM pain management. [41][42][43][44][45][46][47] Lesion reduction was also observed in studies combining LLLT/PBM treatment with photosensitizers though to a lesser extent. 48,49 This combination was recommended to reduce the OM grade, shorten the recovery period, 50 and if an infection was suspected.…”

Section: Resultsmentioning

confidence: 78%

Decade Long Survey of Low-level Laser Therapy/Photobiomodulation (LLLT/PBM) Therapy for Oral Mucositis Treatment

et al. 2021

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Low-level laser therapy or photobiomodulation (LLLT/PBM) therapy has been widely applied to enhance and accelerate the recovery of oral mucositis. This study investigates the documented effect of LLLT on oral mucositis caused by chemotherapy. This review appraises 6 animal studies and 12 clinical studies published in the Pubmed database during the past 10 years, related to the application of LLLT for the treatment of mucositis. Despite varied parameters and diverse conditions, the assessed articles indicate that application of LLLT on oral mucositis using near-infrared wavelengths is prophylactic, reduces pain, and enables a rapid recovery. Various combined treatments were also identified among the published papers, which further establishes the efficacy of LLLT as a viable treatment.

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“…For example, the use of popsicles instead of ice or ice water for younger patients undergoing oral cryotherapy may increase compliance during the application [62]. Likewise, extra-oral PBM may be tolerated better than the intra-oral approach [65,68,69]. Studies in cancer and non-cancer pediatric patients suggested strategies utilizing cognitive-behavioral approaches may help to handle stressful situations and consequently enhance engagement in children.…”

Section: Discussionmentioning

confidence: 99%

“…Following the timeframe of the literature search of the MASCC/ISOO guidelines update, 15 RCTs were published addressing interventions for the management of OM in pediatric cancer patients. The new RCTs investigated the use of natural & miscellaneous agents [76][77][78][79][80][81][82], PBM therapy [68,[83][84][85][86], oral cryotherapy [87], G-CSF [88], and KGF-1 vs. chlorhexidine mouthwashes [89]. These newer RCTs suggest efficacy for honey and inefficacy for SCPR.…”

Section: Discussionmentioning

confidence: 99%

MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

Miranda-Silva

Gomes-Silva

Zadik

et al. 2020

Support Care Cancer

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Photobiomodulation with a combination of two wavelengths in the treatment of oral mucositis in children: The PEDIALASE feasibility study

Cited by 15 publications

References 31 publications

Oral mucositis in childhood cancer patients receiving high‐dose methotrexate: Prevalence, relationship with other toxicities and methotrexate elimination

Oral mucositis in childhood cancer patients receiving high‐dose methotrexate: Prevalence, relationship with other toxicities and methotrexate elimination

Decade Long Survey of Low-level Laser Therapy/Photobiomodulation (LLLT/PBM) Therapy for Oral Mucositis Treatment

MASCC/ISOO clinical practice guidelines for the management of mucositis: sub-analysis of current interventions for the management of oral mucositis in pediatric cancer patients

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