Photobiomodulation in Oral Medicine

Kalhori, Katayoun Am; Vahdatinia, Farshid; Jamalpour, Mohammad Reza; Vescovi, Paolo; Fornaini, Carlo; Merigo, Elisabetta; Fekrazad, Reza

doi:10.1089/photob.2019.4706

Cited by 30 publications

(18 citation statements)

References 111 publications

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“…OLP is an autoimmune chronic inflammatory disease [ 5 , 8 ] and since PBM was shown to be an effective method for the attenuation of inflammation, the idea of applying PBM was rational to be suggested as an alternative approach for the management of OLP [ 4 , 17 ]. Today, it is well-established that PBM reduces the inflammatory process, accelerates wound healing and tissue regeneration, prevents fibrosis, reduces pain and improves function [ 4 , 10 , 17 , 18 ]. These photobiological reactions have been shown to occur in various tissues and were proven by different studies on different pathological conditions to be reliable and predictable if the correct parameters and protocol are applied [ 4 , 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Today, it is well-established that PBM reduces the inflammatory process, accelerates wound healing and tissue regeneration, prevents fibrosis, reduces pain and improves function [ 4 , 10 , 17 , 18 ]. These photobiological reactions have been shown to occur in various tissues and were proven by different studies on different pathological conditions to be reliable and predictable if the correct parameters and protocol are applied [ 4 , 18 , 19 ]. Although there has been significant improvement in understanding PBM’s underlying mechanism of action, the exact mechanism is not fully understood [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

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Photobiomodulation Therapy vs. Corticosteroid for the Management of Erosive/Ulcerative and Painful Oral Lichen Planus. Assessment of Success Rate during One-Year Follow-Up: A Retrospective Study

Nammour

Mobadder

Brugnera³

et al. 2021

Healthcare

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Photobiomodulation (PBM) therapy is a promising approach for the management of inflammatory conditions and autoimmune lesions, such as oral lichen planus (OLP). The aim of this retrospective study was to assess the effectiveness of PBM in the management of painful and erosive/ulcerative OLP and to compare it with the standard of care that is the topical application of corticosteroids. 96 patients were included with erosive and painful OLP. 48 patients received PBM therapy and 48 received corticosteroids. Data was collected retrospectively on pain using the visual analogue scale; clinical aspects of lesions were assessed with the REU score, and the recurrence rate was noted. One session of PBM therapy with a helium-neon red light (635 nm) was carried out every 48 h for 6 weeks. Treatments were mainly made in contact mode, using a fiber with a diameter of 600 µm (0.6 mm). The output power of the laser beam was calibrated by a power meter. A delivered power of 0.1 W was used for 40 s in a continuous wave (CW), corresponding to a delivered energy of 4 J. The delivered energy density related to the fiber diameter was 1415 J/cm2. Each treated point was considered as 1 cm2 of diameter. PBM therapy within these parameters was carried out on each point until the totality of the lesion was covered, including the non-erosive OLP area. Furthermore, healthy mucosa within 5 mm of the lesion was also irradiated with the same conditions. This PBM treatment was performed during 6 consecutive weeks. The topical corticosteroid treatment consisted of cortisone application to cover the OLP 3 times/day for 6 weeks. Follow-up was made at 6 weeks and at 3, 6 and 12 months. After 6 weeks, both groups showed complete absence of pain, and a complete disappearance of ulcerative/erosive areas. No significant difference was found for both groups concerning the recurrence rate of erosive OLP during the follow-up period; values were 0% at 6 weeks for both groups and 79% and 87.5% for the corticosteroid and PBM group, respectively, at 12 months of follow-up. PBM is effective for managing OLP and is significantly similar to topical corticosteroids without any need for the use of medication and with no reported side effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Photobiomodulation Therapy vs. Corticosteroid for the Management of Erosive/Ulcerative and Painful Oral Lichen Planus. Assessment of Success Rate during One-Year Follow-Up: A Retrospective Study

Nammour

Mobadder

Brugnera³

et al. 2021

Healthcare

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“…LPBM has been attracting more interest in dentistry, with increasing applicability in this field. Several approaches have incorporated LPBM as an adjuvant to reduce the inflammatory process, aiming a modulation effect, as well as a restorative stimulus for bone, muscular and neural lesions 12,13,15,17,22,23 . The LPBM was used in this study, with the perspective of minimizing possible cytotoxic effects of endodontic drugs in contact with cells in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, these medications should present the ability to induce repair in the injured area without interfering with osteogenesis and cementogenesis [9][10][11] . Searching strategies to minimize tissue damage, the association between intracanal medications and laser photobiomodulation (LPBM) has been proposed 12,13 . LPBM is the term applied to describe the wide range of laser applications with low-energy densities and based on photochemical mechanisms where the energy is transferred to the intracellular mitochondrial chromophores and respiratory chain components 12,14 .…”

Section: Introductionmentioning

confidence: 99%

“…LPBM is the term applied to describe the wide range of laser applications with low-energy densities and based on photochemical mechanisms where the energy is transferred to the intracellular mitochondrial chromophores and respiratory chain components 12,14 . Thus, LPBM is an electromagnetic radiation source with characteristics (monochromaticity, coherence, and one-pointedness) that differentiate it from other light fonts showing several clinical applications with anti-inflammatory, analgesic, and trophic-regenerative effects 12,13 . LPBM can induce cell's metabolic changes through a series of cascading reactions through photochemical and photoelectric with primary and secondary effects on exposed tissue to laser irradiation 12 .…”

Section: Introductionmentioning

confidence: 99%

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Laser photobiomodulation effect on fibroblasts viability exposed to endodontic medications

Lima

Chisini²,

Conde³

et al. 2021

Braz. J. Oral Sci.

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Aim: The literature has not yet reported investigations about the effect of laser photobiomodulation (LPBM) over the cytotoxicity of drugs for endodontic treatments. Thus, the aim of this study was to evaluate, in vitro, the effect of the association between LPBM and intracanal medications on fibroblasts viability in different exposure times. Methods: Calcium hydroxide (Ca(OH)2) and iodoform (IO) were used pure or associated to LPBM. Eluates of medications were prepared and placed in contact with the cells in three different periods: 24h, 48h and 72h. Laser irradiation (emitting radiation λ 660nm, power density of 10mW, energy density of 3 J/cm²) has been performed in two sessions within a six hour interval, for 12s per well. After each experimental time, the colorimetric assay (MTT) has been performed. Statistical analysis was applied for Mann-Whitney test with 5% α error admitted test. Results: At 24h, the use of LPBM did not increase cell viability while after 72h cell proliferation was stimulated in the group without medications. LPBM application did not increase cell viability in Ca(OH)2 group and IO at any tested time. Ca(OH)2 cytotoxicity at 24h was higher than iodoform, while at 72h not difference was observed. Therefore, after 72 hours was no statistical difference between the IO and Ca(OH)2 groups. Conclusion: LPBM was able to increase cell viability in 72h in the group without medication, although no improvement was observed in the other groups. Thus, LPBM was not able to reduce the cytotoxic effects of the materials on fibroblasts in vitro.

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