Photobiomodulation for the treatment of periodontal pockets in patients with type 2 diabetes: 1-year results of a randomized clinical trial

Santos, Nídia Cristina Castro dos; Andere, Naira Maria Rebelatto Bechara; Miguel, Manuela Maria Viana; Santos, Lúcio Murilo dos; Santamaria, Milton; Mathias, Ingrid Fernandes; Jardini, Maria Aparecida Neves; Santamaría, Mauro Pedrine

doi:10.1007/s10103-019-02799-0

Cited by 12 publications

(6 citation statements)

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“…Thus, reinforcing that laser therapy has immediate wound healing properties. 43 However, bone neoformation percentage after photobiomodulation depends on the target tissue and parameters, such as those described by de Freitas and Hamblin who described the regulation mechanisms of PBM. 36 Concerning the molecular regulation mechanisms of bone neoformation in photobiomodulation, the authors described that the receptor activator of nuclear factor-kB (RANK) and osteoprotegerin (OPG) ratio determines whether the bone is reabsorbed or formed during the remodeling process.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Photobiomodulation Therapy in Different Doses on Bone Repair of Critical Size Defects in Rats: A Histomorphometric Study

Marco

Torquato

Gonçalves³

et al. 2021

J Lasers Med Sci

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Introduction: Photobiomodulation therapy (PBM) appears to induce osteogenesis and stimulate fracture repair; because of its capacity, it is considered a promising treatment, but the characteristics of response to different radiation doses must be investigated through in vivo studies to establish their safety and effectiveness. Thus, this paper aims to analyze the effects of the PBM at different doses on the repair of critical bone defects through histological and histomorphometric analyses. Methods: Sixty 90-day-old adult rats (Rattus norvegicus, albinus, Wistar) weighing approximately 300 g were used. Critical bone defects of 5 mm in diameter were performed in their calvaria. The animals were randomly separated into 5 groups: C-Blood clot, L15-PBM 15J/cm2 , L30-PBM 30 J/ cm2 , L45-PBM 45 J/cm2 , L60-PBM 60 J/cm2 . Each group was subdivided according to observation periods of 30 and 60 days with 6 rats in each subgroup. Low-level gallium aluminum arsenide (GaAlAs) lasers were used at a 660 nm wavelength, 30 mW and 0.04 cm2 in area. The PBM was applied over 5 points; 4 points of application were distributed on the edges while one point of application was located in the center of the bone defect. PBM occurred right after the procedure. In 30 and 60 days, the animals were euthanized by anesthesia overdose and the analyses were performed. The data were analyzed statistically by the ANOVA, together with the Tukey test, whose significance level was 5%. Results: As regards the treatment factor, the highest percentage of bone neoformation was achieved by group L45-60. The group with the highest closure, despite not having a statistically significant difference with the other doses, was 45 J with only 0.49 mm between edges. Conclusion: Thus, the present study allowed concluding that the highest percentage of bone neoformation area was achieved at 45 J/cm2 in 60 days; that is, it was significantly effective in comparison with other doses.

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Section: Discussionmentioning

confidence: 99%

The Effect of Photobiomodulation Therapy in Different Doses on Bone Repair of Critical Size Defects in Rats: A Histomorphometric Study

Marco

Torquato

Gonçalves³

et al. 2021

J Lasers Med Sci

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“…These articles were evaluated based on the eligibility criteria of the review. Additional studies were excluded due to the following reasons: an inappropriate study design or article type in 9 studies (15,16,21–27), LLLT utilized, as an adjunct to a surgical intervention or in the supportive periodontal therapy phase in 3 studies (28–30), in vitro or in vivo animal studies utilized in 3 papers (31–33), participants with systemic diseases recruited in 3 studies (34–39), no utilization of PBM in 11 studies (40–50), and LLLT utilized either; as a mono‐therapeutic agent or in combination with aPDT in 3 studies (51–53) (inter‐reviewer agreement, κ = 1). Hence, out of 52 full text articles, 35 articles were excluded, due to the abovementioned reasons, while the remaining 17 articles were included and analyzed in the present systematic review.…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Photobiomodulation as an Adjunct to Nonsurgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies

Dalvi

Benedicenti

Hanna

2020

Photochem & Photobiology

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Photobiomodulation therapy (PBMT) has anti‐inflammatory, analgesic and regenerative properties. This systematic review aimed to critically appraise the published data of in vivo human randomized clinical trials (RCTs), and present a comprehensive overview of the efficacy of PBMT, as an adjunct to the nonsurgical periodontal therapy (NSPT) in the management of periodontitis. The systematic review protocol is registered in the Prospective Register Of Systematic Reviews (PROSPERO) (http://www.crd.york.ac.uk/PROSPERO/; ref CRD 42020169108). With the help of the appropriate key words, structured electronic and manual search strategies were applied to gather the relevant published data on in vivo human RCTs based on this topic. Seventeen papers that met the eligibility criteria were included in this review and subjected to a qualitative assessment. Current evidence lacks adequate information regarding the photobiomodulation (PBM) dosimetry, which is fundamental in establishing a standardized and replicable protocol for future researches. Furthermore, substantial discrepancies in the study methodology and a high risk of bias, arising from the majority of the included papers, abet to the inferior quality of these studies. Ultimately, there is an urgent necessity to conduct further well‐designed RCTs in order to determine the effectiveness of PBMT, if any, by taking into consideration the abovementioned confounding factors.

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“…Among studies that examined the gingival index, plaque index, and clinical attachment level, 75% reported improvements in at least one of these parameters. Four studies reported negative results: one had the highest fluence ( 144 ), one had the highest exposure frequency [once a day for 8 weeks ( 35 )], one had poorly described illumination parameters and a wavelength beyond the infrared range ( 142 ), and one had four PBM exposure sites ( 148 ), whereas most studies reported one to two exposure sites. Finally, the ideal parameters could involve a single exposure or exposure over 2 to 3 days, on one to two sites in direct contact with gingival tissue or intra-pocket, with a fluence of 1 to a few J/cm², continuous or pulsed laser illumination, and a wavelength range of 650 to 1064 nm.…”

Section: Discussionmentioning

confidence: 99%

Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization

Perrier,

Moro,

Lablanche

2024

Front. Endocrinol.

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IntroductionDiabetes is a global health concern characterized by chronic hyperglycemia resulting from insulinopenia and/or insulin resistance. The rising prevalence of diabetes and its associated complications (ulcers, periodontitis, healing of bone defect, neuropathy, retinopathy, cardiopathy and nephropathy) necessitate innovative therapeutic approaches. Photobiomodulation (PBM), involves exposing tissues and cells to low-energy light radiation, leading to biological effects, largely via mitochondrial activation.MethodsThis review evaluates preclinical and clinical studies exploring the potential of PBM in diabetes and its complications, as well all clinical trials, both planned and completed, available on ClinicalTrials database.ResultsThis review highlights the variability in PBM parameters across studies, hindering consensus on optimal protocols. Standardization of treatment parameters and rigorous clinical trials are needed to unlock PBM’s full therapeutic potential. 87 clinical trials were identified that investigated PBM in diabetes mellitus (with 5,837 patients planned to be treated with PBM). Clinical trials assessing PBM effects on diabetic neuropathy revealed pain reduction and potential quality of life improvement. Studies focusing on wound healing indicated encouraging results, with PBM enhancing angiogenesis, fibroblast proliferation, and collagen density. PBM’s impact on diabetic retinopathy remains inconclusive however, requiring further investigation. In glycemic control, PBM exhibits positive effects on metabolic parameters, including glucose tolerance and insulin resistance.ConclusionClinical studies have reported PBM-induced reductions in fasting and postprandial glycemia without an increased hypoglycemic risk. This impact of PBM may be related to its effects on the beta cells and islets in the pancreas. Notwithstanding challenges, PBM emerges as a promising adjunctive therapy for managing diabetic neuropathy, wound healing, and glycemic control. Further investigation into its impact on diabetic retinopathy and muscle recovery is warranted.

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Photobiomodulation for the treatment of periodontal pockets in patients with type 2 diabetes: 1-year results of a randomized clinical trial

Cited by 12 publications

References 43 publications

The Effect of Photobiomodulation Therapy in Different Doses on Bone Repair of Critical Size Defects in Rats: A Histomorphometric Study

The Effect of Photobiomodulation Therapy in Different Doses on Bone Repair of Critical Size Defects in Rats: A Histomorphometric Study

Effectiveness of Photobiomodulation as an Adjunct to Nonsurgical Periodontal Therapy in the Management of Periodontitis‐ A Systematic Review of in vivo Human Studies

Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization

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