Photobiomodulation and photodynamic therapy for the management of oral graft-versus-host disease: A case report

Antimicrobial photodynamic therapy for recurrent herpes labialis in chronic graft‐versus‐host disease: A case report

“…6 Herein, no further antiviral drug was administered to the patient, a fact that highlights the virucidal effects of aPDT. 5 In general, recurrent herpes labialis may occur in response to either internal or external stimuli as stress, immunosuppression, high fever, trauma, and ultraviolet light. 7 Interestingly, several light sources in association with photosensitizing agents have already been investigated for viral photoinactivation, including ultraviolet light.…”

“…Clinicians should thus monitor the patients since lesions that have not healed within 7‐10 days need to be either recultured or biopsied, and sensitivity tests should also be obtained 6 . Herein, no further antiviral drug was administered to the patient, a fact that highlights the virucidal effects of aPDT 5 …”

“…proposed to treat viral infections, and a combination of aPDT and photobiomodulation therapy has already been used for the management of oral GVHD. 4,5 So, the present study reports a clinical case in which this therapy was used to manage an ulcerative lesion of recurrent herpes labialis in a patient with chronic GVHD. Later in the clinical course of chronic GVHD, the patient presented uninterrupted pain on the labial and buccal mucosa, which was negatively impacting his oral functions and daily activities.…”

“…Antimicrobial photodynamic therapy (aPDT) has been recently proposed to treat viral infections, and a combination of aPDT and photobiomodulation therapy has already been used for the management of oral GVHD 4,5 . So, the present study reports a clinical case in which this therapy was used to manage an ulcerative lesion of recurrent herpes labialis in a patient with chronic GVHD.…”

Phototherapies in the management of an ulcerative lip lesion in a patient taking multiple medications for rheumatoid arthritis

“…For that, 0.01 % methylene blue was applied over the lesion and, after 5 min (time pre-irradiation), the laser Therapy EC® (DMC, São Carlos, SP, Brazil) was used at 660 nm, on contact mode, with 100 mW, 35 J/cm2, 5 J, and 50 s. Moreover, two PBMT sessions were carried out with a 24-hours interval on the same area previously described (5 points) and using the same equipment, but applying 100 mW, 35 J/cm2, 2 J, and 20 s of irradiation per point (Figure 1B). The protocols were based on other studies (Campos et al, 2020;Rezende et al, 2020;Ramires et al, 2021).…”