Photoactivation of curcumin and sodium hypochlorite to enhance antibiofilm efficacy in root canal dentin

Neelakantan, Prasanna; Cheng, Cheng Qing; Ravichandran, Vinoddhine; Mao, Teresa; Sriraman, P. K.; Sridharan, Swetha; Subbarao, Chandana; Sharma, Subash; Kishen, Anil

doi:10.1016/j.pdpdt.2014.10.011

Cited by 60 publications

(60 citation statements)

References 36 publications

(55 reference statements)

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“…Neelakantan et al determined the anti-biofilm efficacy of the combination therapy using blue light (380–515 nm) with curcumin, a medicinal plant extract exhibiting antimicrobial effect, and compared it with the combination therapy of using ultrasonic files with curcumin (Neelakantan et al, 2015). E. faecalis biofilms grown within root canals irradiated with blue light (1200 mW/cm 2 for 4 min) or activated with ultrasonic files (30 s cycles for 4 min).…”

Section: Synergism Of Antimicrobial Blue Light With Other Agentsmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

223

192

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As an innovative non-antibiotic approach, antimicrobial blue light in the spectrum of 400–470 nm has demonstrated its intrinsic antimicrobial properties resulting from the presence of endogenous photosensitizing chromophores in pathogenic microbes and, subsequently, its promise as a counteracter of antibiotic resistance. Since we published our last review of antimicrobial blue light in 2012, there have been a substantial number of new studies reported in this area. Here we provide an updated overview of the findings from the new studies over the past 5 years, including the efficacy of antimicrobial blue light inactivation of different microbes, its mechanism of action, synergism of antimicrobial blue light with other angents, its effect on host cells and tissues, the potential development of resistance to antimicrobial blue light by microbes, and a novel interstitial delivery approach of antimicrobial blue light. The potential new applications of antimicrobial blue light are also discussed.

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Section: Synergism Of Antimicrobial Blue Light With Other Agentsmentioning

confidence: 99%

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Wang

et al. 2017

Drug Resistance Updates

223

192

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“…Nesta investigação, a solução química irrigadora mais utilizada, correspondeu à solução de hipoclorito de sódio. Em seu estudo in vitro Neelakantab 12 utilizaram o hipoclorito de sódio a 3% e a curcumina fotoativada como solução irrigadora objetivando comparar a eficácia dessas duas substâncias e concluíram que a última apresentou significativamente maior capacidade antibacteriana. Outro estudo feito por Juric 17 analisou o hipoclorito de sódio a 5,25% como irrigante e a solução QMiX, obtiveram como resultado que o hipoclorito de sódio foi capaz de reduzir 99,99% Enterococcus faecalis sendo mais significante do que os outros protocolos utilizados.…”

Section: Discussionunclassified

Análise do uso da terapia fotodinâmica no tratamento endodôntico com base em um Congresso Odontológico

Santos

Brito²,

Neves³

et al. 2017

Rev. da Fac. de Odontologia, UPF

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Um dos objetivos do tratamento endodôntico é a máxi-ma desinfecção do sistema de canais radiculares, bem como, a prevenção da sua reinfecção. A terapia fotodi- IntroduçãoA infecção endodôntica ocorre com a proliferação de bactérias no interior dos canais radiculares que adentraram nesse meio através da exposição do dente ao ambiente oral, devido a lesões cariosas ou traumáticas, causando a formação de lesões perirradiculares persistentes 1,2 . Dessa forma, o tratamento endodôntico deve ser realizado como medida para eliminar e inativar os biofilmes bacterianos e seus subprodutos facilitando assim a reparação dos tecidos apicais 1,3 . Durante o preparo químico mecânico utiliza-se instrumentos manuais ou mecanizados, concomitante a irrigação com substâncias químicas, e em alguns casos, o uso de medicação intra-canal entre as sessões clínicas, obtendo assim relativas taxas de sucesso na diminuição da quantidade de bacté-rias presentes nos canais radiculares 2,4,5,6 . Está bem evidenciado na atual literatura, que a desinfecção completa dos canais radiculares é bastante difícil, devido à diversidade dos sistemas de canais radiculares na região apical onde há maior predomínio de deltas apicais e formação de biofilme extraradicular, o que dificulta a eliminação de micro-organismos resistentes, tal como o Enterococcus Facaelis 5,7,8 . O tratamento endodôntico convencional falha na inativação e eliminação das endotoxinas bacterianas como os lipopolissacarídeos que são liberados provocando infecções endodônticas graves que comprometem o sucesso da terapia endodôntica 2,6 .

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“…After assessing the different studies, which used curcumin as a PS, it was concluded that the application of a PS accompanied by LED irradiation enhanced the results. 57,58 Overall, the literature survey suggested that the best approach is to use TBO and MB with concentrations under 100 µg/mL and an incubation time of 1 to 5 minutes, followed by laser irradiation for a period of time that is mainly dependent on the output power of the device which defines the dose. It should also be kept in mind that aPDT should be performed following conventional instrumentation and irrigation.…”

Section: Discussionmentioning

confidence: 99%

Can Antimicrobial Photodynamic Therapy (aPDT) Enhance the Endodontic Treatment?

et al. 2016

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In order to achieve a long-lasting effect, one of the main goals in root canal treatment is to eliminate the endodontic bacteria. Conventional chemomechanical debridement is considered as the basic treatment in root canal therapy, but adjunctive techniques such as antimicrobial photodynamic therapy (aPDT) can also be helpful. The aim of this study was to evaluate reports in the scientific literature that used different photosensitizers (PSs) for bacterial reduction. The literature search was conducted using databases including PubMed, Scopus, and Google Scholar with the keywords "photodynamic therapy," "antimicrobial photodynamic therapy," or "photoactivated disinfection" and "endodontic," "Enterococcus faecalis," or "root canal treatment," from 2000 to 2015. By evaluating different studies, it was concluded that aPDT should be applied in combination with conventional mechanical debridement and irrigants. However, it is also important to note that the success rate is critically dependent on the type of the PS, output power of the laser used, irradiation time, pre-irradiation time, and type of tips used.

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Photoactivation of curcumin and sodium hypochlorite to enhance antibiofilm efficacy in root canal dentin

Cited by 60 publications

References 36 publications

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Antimicrobial blue light inactivation of pathogenic microbes: State of the art

Análise do uso da terapia fotodinâmica no tratamento endodôntico com base em um Congresso Odontológico

Can Antimicrobial Photodynamic Therapy (aPDT) Enhance the Endodontic Treatment?

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