Photoactivated DNA cleavage via charge transfer promoted N2 release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

Maurer, Tucker D.; Kraft, Brian J.; Lato, Susan M.; Ellington, Andrew D.; Zaleski, Jeffrey M.

doi:10.1039/a908005h

Cited by 37 publications

(27 citation statements)

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“…The organic compounds that are known to show oxygen independent DNA cleavage activity are primarily limited to photo-irradiation with UV light [11,12]. Compounds showing anaerobic DNA cleavage in visible light are rare in the literature and are generally limited to transition metal complexes [13][14][15][16]. Tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III) complex is known to cleave DNA anaerobically by producing localized reactive ligand radical intermediate promoted by N 2 release on photolysis at λ ≥ 455 nm [13].…”

Section: Introductionmentioning

confidence: 99%

“…Compounds showing anaerobic DNA cleavage in visible light are rare in the literature and are generally limited to transition metal complexes [13][14][15][16]. Tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III) complex is known to cleave DNA anaerobically by producing localized reactive ligand radical intermediate promoted by N 2 release on photolysis at λ ≥ 455 nm [13]. Copper metalloenediynes are known to show anaerobic DNA photocleavage activity at λ ≥ 395 nm [14].…”

Section: Introductionmentioning

confidence: 99%

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Remarkable photocytotoxicity in hypoxic HeLa cells by a dipyridophenazine copper(II) Schiff base thiolate

Lahiri

Majumdar

Mallick

et al. 2011

Journal of Inorganic Biochemistry

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Remarkable photocytotoxicity in hypoxic HeLa cells by a dipyridophenazine copper(II) Schiff base thiolate

Lahiri

Majumdar

Mallick

et al. 2011

Journal of Inorganic Biochemistry

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“…They are capable of releasing bioactive molecules photophysically. Iron (III) triazine complex can cleave plasmid DNA by producing ROS upon irradiation (72 h, λ irr > 455 nm) in a LMCT excitation (139). Hydroxyl, superoxide and triazine radicals all can cleave DNA.…”

Section: Inorganic Compounds For Photoactivated Chemotherapy (Pact)mentioning

confidence: 99%

Inorganic Nanoparticles in Cancer Therapy

et al. 2010

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Nanotechnology is an evolving field with enormous potential for biomedical applications. The growing interest to use inorganic nanoparticles in medicine is due to the unique size and shapedependent optoelectronic properties. Herein, we will focus on gold, silver and platinum nanoparticles, discussing recent developments for therapeutic applications with regard to cancer in terms of nanoparticles being used as a delivery vehicle as well as therapeutic agents. We will also discuss some of the key challenges to be addressed in future studies. IntroductionNanotechnology is a flourishing area with several interdisciplinary fields, such as medicine, electronics, and biomaterials (1). The long-term goal of nanomedicine is to revolutionize the health care system by fighting deadly diseases in more efficient ways (1). Gold nanoparticles are being investigated for biological applications due to their biocompatibility (1,2). In this review, we will focus on gold and a few other inorganic nanoparticles and discuss their potential applications in therapy and imaging. Gold nanoparticles have been used mostly as a probe for electron microscopy and as a delivery vehicle for biomolecules. However, the use of nanoparticles as a therapeutic agent is relatively new. Among all the nanomaterials, gold has attracted wide attention due to its relative non-toxic nature (2-5). Gold has been shown to have strong affinity to thiol and amine functionalities (2). Such affinity enables surface modifications to gold nanoparticles relatively easily through Au-S and Au-N bonding with targeting agents and/or chemotherapeutics that possess these functionalities (2). Thus, through intelligent design it is possible to develop multifunctional nanoparticles that could potentially increase the efficiency of detection, diagnosis and therapy (2,3). Application of Gold in Ancient MedicineGold compounds were used by Chinese and Indian cultures as early as 2500-2600 BC in the form of "Swarna Bhasma," a gold based medicine, for various purposes such as increasing vital power and curing male impotence (4-6). In the early 19 th and 20 th centuries gold compounds were utilized for the treatment of epilepsy, syphilis, rheumatic diseases, * Corresponding Author: Priyabrata Mukherjee, Ph.D, Department of Biochemistry and Molecular Biology, Department of Biomedical Engineering, Cancer Center, Mayo Clinic, Rochester, MN-55905, mukherjee.priyabrata@mayo.edu, Phone: 507-284-8563, Fax: 507-293-1058. NIH Public Access Synthesis of NanoparticlesPreparation of gold nanoparticles (AuNP) of different sizes and shapes are well documented (2,5,15,16 Physio-Chemical Properties of Metal NanoparticlesThe tunablility of optoelectronic properties through shape and size-dependent properties make inorganic nanomaterials unique for various biomedical applications (33)(34)(35)(36). Inorganic nanoparticles such as gold, silver and copper possess brilliant colors due to the presence of [39][40][41][42][43]. AuNPs show a strong SPR band that is dependent on particle size (...

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“…Metal complexes that bind and cleave DNA or proteins under physiological conditions are of current interests for their varied applications in nucleic acid and protein chemistry [12][13][14][15][16]. It is known that the distribution, free concentration, and the metabolism of various drugs are strongly affected by drug-protein interactions in the bloodstream [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Mechanistic and Conformational Studies on the Interaction of a Platinum(II) Complex Containing an Antiepileptic Drug, Levetiracetam, With Bovine Serum Albumin by Optical Spectroscopic Techniques in Aqueous Solution

Shahabadi

Hadidi

2014

Appl Biochem Biotechnol

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Fluorescence spectroscopy in combination with circular dichroism (CD) and ultraviolet-visible (UV-vis) absorption spectroscopy were employed to investigate the binding of a new platinum(II) complex containing an antiepileptic drug "Levetiracetam" to bovine serum albumin (BSA) under the physiological conditions. In the mechanism discussion, it was proved that the fluorescence quenching of BSA by Pt(II) complex is a result of the formation of Pt(II) complex-BSA complex. The thermodynamic parameters ΔG, ΔH, and ΔS at different temperatures (283, 298, and 310 K) were calculated, and the negative value for ΔH and ΔS indicate that the hydrogen bonds and van der Waals interactions play major roles in Pt(II) complex-BSA association. Binding studies concerning the number of binding sites (n~1) and apparent binding constant K b were performed by fluorescence quenching method. The site marker competitive experiments indicated that the binding of Pt(II) complex to BSA primarily took place in site II. Based on the Förster's theory, the average binding distance between Pt(II) complex and BSA was obtained (r = 5.29 nm). Furthermore, UV-vis, CD, and synchronous fluorescence spectrum were used to investigate the structural change of BSA molecules with addition of Pt(II) complex. These results indicate that the binding of Pt(II) complex to BSA causes apparent change in the secondary structure of BSA and do affect the microenvironment around the tryptophan residue.

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Photoactivated DNA cleavage via charge transfer promoted N2 release from tris[3-hydroxy-1,2,3-benzotriazine-4(3H)-one]iron(III)

Cited by 37 publications

References 10 publications

Remarkable photocytotoxicity in hypoxic HeLa cells by a dipyridophenazine copper(II) Schiff base thiolate

Remarkable photocytotoxicity in hypoxic HeLa cells by a dipyridophenazine copper(II) Schiff base thiolate

Inorganic Nanoparticles in Cancer Therapy

Mechanistic and Conformational Studies on the Interaction of a Platinum(II) Complex Containing an Antiepileptic Drug, Levetiracetam, With Bovine Serum Albumin by Optical Spectroscopic Techniques in Aqueous Solution

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