Photoacoustic tomography for imaging the prostate: a transurethral illumination probe design and application

Ai, Min; Youn, Jong-In; Salcudean, Septimiu E.; Rohling, Robert; Abolmaesumi, Purang; Tang, Shuo

doi:10.1364/boe.10.002588

Cited by 22 publications

(14 citation statements)

References 52 publications

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“…[92][93][94][95][96][97] Prostate cancer, which is the most common cancer among men, is an excellent target for PAE based on the optical absorption from endogenous molecules. [98] Ishihara et al studied the prostate cancer with the combination of PAE and EUS. [99] Figure 9A shows the representative PA and US images obtained from prostate cancer patients before they took biopsy and radical prostatectomy.…”

Section: Reproductive Systemmentioning

confidence: 99%

Photoacoustic endoscopy: A progress review

Guo

Liu

et al. 2020

Journal of Biophotonics

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Endoscopy has been widely used in biomedical imaging and integrated with various optical and acoustic imaging modalities. Photoacoustic imaging (PAI), one of the fastest growing biomedical imaging modalities, is a noninvasive and nonionizing method that owns rich optical contrast, deep acoustic penetration depth, multiscale and multiparametric imaging capability. Hence, it is preferred to miniaturize the volume of PAI and develop an emerged endoscopic imaging modality referred to as photoacoustic endoscopy (PAE). It has been developed for more than one decade since the first report of PAE. Unfortunately, until now, there is no mature photoacoustic endoscopic technique recognized in clinic due to various technical limitations. To address this concern, recent development of new scanning mechanisms, adoption of novel optical/acoustic devices, utilization of superior computation methods and exploration of multimodality strategies have significantly promoted the progress of PAE toward clinic. In this review, we comprehensively reviewed recent progresses in single-and multimodality PAE with new physics, mechanisms and strategies to achieve practical devices for potential applicable scenarios including esophageal, gastrointestinal, urogenital and intravascular imaging. We ended this review with challenges and prospects for future development of PAE. K E Y W O R D S multimodality, photoacoustic endoscopy, potential clinical applications, scanning mechanism 1 | INTRODUCTION Endoscopy is an emerging imaging technology that involves optics, acoustics, precision machinery and data processing. [1,2] Owning to the urgent need of imaging deep-located biological tissues/organs, biomedical endoscopy has been extensively applied in various fundamental and clinical studies. [3-5] Comparing with clinical imaging modalities such as X-ray, computed tomography (CT), magnetic resonance imaging (MRI), nuclear emission CT, and ultrasonography (US) which are able to visualize internal biological tissues/organs, endoscopic modalities Heng Guo and Ying Li contributed equally.

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Section: Reproductive Systemmentioning

confidence: 99%

Photoacoustic endoscopy: A progress review

Guo

Liu

et al. 2020

Journal of Biophotonics

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“…To make a radial-emission fiber diffuser, the jacket and cladding of an optical fiber are removed, and the surface of the fiber core is roughened to scatter the light out. 47 , 48 , 88 The fiber core can also be coated with a layer of optically scattering particles to further homogenize the light emission. 50 , 89 , 90 In contrast, a frontal diffuser is typically separable from the optical fiber.…”

Section: Technical Advancements In Molecular Patmentioning

confidence: 99%

“… 40 - 43 Numerous efforts have been made by various research groups to address the aforementioned challenges. Through careful selection of excitation wavelength, 44 - 46 optimization of light delivery, 47 - 50 and sophisticated design and fabrication of the ultrasonic transducer, 51 - 55 the penetration depth of PAT has been substantially improved. Moreover, by increasing the imaging speed or frame rate, PAT can reduce the motion artifacts and improve the detection sensitivity with signal averaging, leading to larger imaging depth.…”

Section: Introductionmentioning

confidence: 99%

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths

Nyayapathi

Kilian

et al. 2020

Mol Imaging

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Photoacoustic tomography (PAT) has become increasingly popular for molecular imaging due to its unique optical absorption contrast, high spatial resolution, deep imaging depth, and high imaging speed. Yet, the strong optical attenuation of biological tissues has traditionally prevented PAT from penetrating more than a few centimeters and limited its application for studying deeply seated targets. A variety of PAT technologies have been developed to extend the imaging depth, including employing deep-penetrating microwaves and X-ray photons as excitation sources, delivering the light to the inside of the organ, reshaping the light wavefront to better focus into scattering medium, as well as improving the sensitivity of ultrasonic transducers. At the same time, novel optical fluence mapping algorithms and image reconstruction methods have been developed to improve the quantitative accuracy of PAT, which is crucial to recover weak molecular signals at larger depths. The development of highly-absorbing near-infrared PA molecular probes has also flourished to provide high sensitivity and specificity in studying cellular processes. This review aims to introduce the recent developments in deep PA molecular imaging, including novel imaging systems, image processing methods and molecular probes, as well as their representative biomedical applications. Existing challenges and future directions are also discussed.

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“…Applications of PAI in cancers include early detection, identifying the stages and metastasis, treatment planning and evaluation. 6–12 PAI is revealed to be successful in the diagnosis of breast, 13–19 prostate, 20–26 thyroid, 27–31 melanoma, 32–36 and ovarian 37–41 cancers. In stroke, PAI is utilized for imaging and understanding mechanical thrombolysis, 42 vessel segmentation, 43 and other vessel injuries that are caused by stroke in the brain.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic image-guided interventions

Karthikesh

Yang

2019

Exp Biol Med (Maywood)

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Photoacoustic imaging has demonstrated its potential for diagnosis over the last few decades. In recent years, its unique imaging capabilities, such as detecting structural, functional and molecular information in deep regions with optical contrast and ultrasound resolution, have opened up many opportunities for photoacoustic imaging to be used during image-guided interventions. Numerous studies have investigated the capability of photoacoustic imaging to guide various interventions such as drug delivery, therapies, surgeries, and biopsies. These studies have demonstrated that photoacoustic imaging can guide these interventions effectively and non-invasively in real-time. In this minireview, we will elucidate the potential of photoacoustic imaging in guiding active and passive drug deliveries, photothermal therapy, and other surgeries and therapies using endogenous and exogenous contrast agents including organic, inorganic, and hybrid nanoparticles, as well as needle-based biopsy procedures. The advantages of photoacoustic imaging in guided interventions will be discussed. It will, therefore, show that photoacoustic imaging has great potential in real-time interventions due to its advantages over current imaging modalities like computed tomography, magnetic resonance imaging, and ultrasound imaging. Impact statement Photoacoustic imaging is an emerging modality for use in image-guided interventional procedures. This imaging technology has a unique ability to offer real-time, non-invasive, cost-effective, and radiation-free guidance in a real-world operating environment. This is substantiated in this article which sums up the current state and underlines promising results of research using photoacoustic imaging in guiding drug delivery, therapy, surgery, and biopsy. Hence, this minireview facilitates future research and real-world application of photoacoustic image-guided interventions.

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Photoacoustic tomography for imaging the prostate: a transurethral illumination probe design and application

Cited by 22 publications

References 52 publications

Photoacoustic endoscopy: A progress review

Photoacoustic endoscopy: A progress review

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths

Photoacoustic image-guided interventions

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