Photoacoustic Tomography Appearance of Fat Necrosis: A First-in-Human Demonstration of Biochemical Signatures along with Histological Correlation

Goh, Yonggeng; Balasundaram, Ghayathri; Tan, Hui; Putti, Thomas Choudary; Ng, Celene Wei Qi; Fang, Eric; Bi, Renzhe; Tang, Siau Wei; Hartman, Mikael; Chan, Ching Wan; Lim, Yi Ting; Olivo, Malini; Quek, Swee Tian

doi:10.3390/diagnostics12102456

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…These conventional components are not portable and cost-effective solutions. Goh et al 10 also used a conventional bulky PA imaging system. Nyayapathi et al 11 and Lin et al 12 presented an outlook on different tomographic imaging systems containing planar, hemispherical, cylindrical imaging systems, etc.…”

Section: Introductionmentioning

confidence: 99%

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Development of a cost-effective compact diode-laser-based photoacoustic sensing instrument for breast tissue diagnosis

Khan,

Mukhopadhyay,

Vasudevan

et al. 2024

J. Biomed. Opt.

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The photoacoustic (PA) technique, a noninvasive pump-probe technique, has found interesting applications in biomedical tissue diagnosis over the last decade. To take it a step further to clinical applications, the PA technique needs to be designed as an instrument focusing on a compact design, reducing the cost, and quickly providing a quantitative diagnosis.Aim: This work presents a design and characterization of a cost-effective, compact PA sensing instrument for biomedical tissue diagnosis.Approach: A compact laser diode case design is developed to house several laser diodes for PA excitation, and a pulsed current supply unit is also developed in-house to power the laser diodes to generate a 25 ns current pulse at a frequency of 20 kHz. After PA experimental data acquisition, the signal's frequency spectra were calculated to characterize the tissue quantitatively and correlated with their mechanobiological properties. Results:The corresponding dominant frequency peak in the PA spectral response (PASR) study was low in the fibrofatty normal breast tissue 0.26 AE 0.03 MHz, compared to the dominant frequency peak of 1.60 AE 0.016 MHz in the fibrocystic disease tissue, which had increased glandular and stromal elements, thereby increased tissue density. The histopathological findings correlated with the PASR results, and the fibrocystic breast disease tissue exhibited a higher dominant frequency peak and energy compared to the normal breast tissue. Conclusions:We experimented with an in vitro PASR study of fibrocystic human breast tissues and successfully differentiated different tissue types using quantitative spectral parameters peak frequency, mean frequency, and spectral energy. This gives the potential to take this technique further for cost-effective and quick clinical applications.

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Section: Introductionmentioning

confidence: 99%

“…These conventional components are not portable and cost-effective solutions. Goh et al 10 . also used a conventional bulky PA imaging system.…”

Section: Introductionmentioning

confidence: 99%

Development of a cost-effective compact diode-laser-based photoacoustic sensing instrument for breast tissue diagnosis

Khan,

Mukhopadhyay,

Vasudevan

et al. 2024

J. Biomed. Opt.

View full text Add to dashboard Cite

show abstract

“…In a case study [19], Y. Goh et al demonstrated the potential of photoacoustic imaging (PA) as a supplement to ultrasound (US) to increase the reliability of lipoma diagnosis. In this case, the authors showed that, using PA, it is possible to study the biochemical characteristics of fat necrosis.…”

mentioning

confidence: 99%