Photoacoustic tomography and sensing in biomedicine

Li, Changhui; Wang, Lihong V.

doi:10.1088/0031-9155/54/19/r01

Cited by 563 publications

(467 citation statements)

References 158 publications

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“…[829] This imaging technique is capable of providing functional imaging based on physiological parameters and thus has gained a widespread acceptance for imaging applications. [830] A considerable combination of excellent absorption contrast and high spatial resolution respectively achieved by ultrasound imaging and optical techniques, enables PAI to produce images with high spatial resolution and with sufficient penetration depth simultaneously. [831] It relies on detecting the acoustic waves which are produced by the thermoelastic expansion of tissue through the adsorption of electromagnetic energy by chrmophores.…”

Section: Paimentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

192

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Paimentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

192

171

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“…Then thermal expansion generates the PA pressure wave. When the conditions of the thermal and stress confinements [2,3] are met, the PA pressure wave is efficiently generated. The propagation of the PA pressure wave in an acoustically homogeneous medium is described by the following wave equation [2,3]:…”

Section: Pa Pressure Wave Propagationmentioning

confidence: 99%

“…Photoacoustic (PA) imaging [1][2][3] noninvasively provides physiological information such as hemodynamics in micro blood vessels. By employing the light propagation model described by the radiative transfer equation (RTE) or the photon diffusion equation (PDE) [4][5][6][7], the PA image of the light absorption coefficient can be reconstructed quantitatively.…”

Section: Introductionmentioning

confidence: 99%

Effects of the approximations of light propagation on quantitative photoacoustic tomography using two-dimensional photon diffusion equation and linearization

Okawa

Hirasawa

Kubota

et al. 2017

Opt Rev

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Quantitative photoacoustic tomography (QPAT) employing a light propagation model will play an important role in medical diagnoses by quantifying the concentration of hemoglobin or a contrast agent. However, QPAT by the light propagation model with the three-dimensional (3D) radiative transfer equation (RTE) requires a huge computational load in the iterative forward calculations involved in the updating process to reconstruct the absorption coefficient. The approximations of the light propagation improve the efficiency of the image reconstruction for the QPAT. In this study, we compared the 3D/ two-dimensional (2D) photon diffusion equation (PDE) approximating 3D RTE with the Monte Carlo simulation based on 3D RTE. Then, the errors in a 2D PDE-based linearized image reconstruction caused by the approximations were quantitatively demonstrated and discussed in the numerical simulations. It was clearly observed that the approximations affected the reconstructed absorption coefficient. The 2D PDE-based linearized algorithm succeeded in the image reconstruction of the region with a large absorption coefficient in the 3D phantom. The value reconstructed in the phantom experiment agreed with that in the numerical simulation, so that it was validated that the numerical simulation of the image reconstruction predicted the relationship between the true absorption coefficient of the target in the 3D medium and the reconstructed value with the 2D PDE-based linearized algorithm. Moreover, the the true absorption coefficient in 3D medium was estimated from the 2D reconstructed image on the basis of the prediction by the numerical simulation. The estimation was successful in the phantom experiment, although some limitations were revealed.

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“…Photoacoustic imaging (PAI) is an exciting, emerging imaging modality that has the ability to combine the high intrinsic contrast of optical imaging with the excellent spatial resolution of ultrasound imaging [1][2][3][4]. The technique is non-invasive and can be performed in real time when used in pulse-echo mode like traditional ultrasound.…”

Section: Introductionmentioning

confidence: 99%

Quantitative photoacoustic image reconstruction improves accuracy in deep tissue structures

Mastanduno¹,

Gambhir²

2016

Biomed. Opt. Express

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Photoacoustic imaging (PAI) is emerging as a potentially powerful imaging tool with multiple applications. Image reconstruction for PAI has been relatively limited because of limited or no modeling of light delivery to deep tissues. This work demonstrates a numerical approach to quantitative photoacoustic image reconstruction that minimizes depth and spectrally derived artifacts. We present the first time-domain quantitative photoacoustic image reconstruction algorithm that models optical sources through acoustic data to create quantitative images of absorption coefficients. We demonstrate quantitative accuracy of less than 5% error in large 3 cm diameter 2D geometries with multiple targets and within 22% error in the largest size quantitative photoacoustic studies to date (6cm diameter). We extend the algorithm to spectral data, reconstructing 6 varying chromophores to within 17% of the true values. This quantitiative PA tomography method was able to improve considerably on filtered-back projection from the standpoint of image quality, absolute, and relative quantification in all our simulation geometries. We characterize the effects of time step size, initial guess, and source configuration on final accuracy. This work could help to generate accurate quantitative images from both endogenous absorbers and exogenous photoacoustic dyes in both preclinical and clinical work, thereby increasing the information content obtained especially from deep-tissue photoacoustic imaging studies. Hahn, and A. G. Yodh, "In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates," Phys. Med. Biol. 47(6), 857-873 (2002)

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Photoacoustic tomography and sensing in biomedicine

Cited by 563 publications

References 158 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Effects of the approximations of light propagation on quantitative photoacoustic tomography using two-dimensional photon diffusion equation and linearization

Quantitative photoacoustic image reconstruction improves accuracy in deep tissue structures

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